I-Urolithin powder

ICofftek inekhono lokukhiqiza ngobuningi nokunikezela nge-urolithin a, urolithin b neMethylurolithin A ngaphansi kwesimo se-cGMP.

Yini ama-Urolithins?

Ama-Urolithin avela noma ama-metabolites wezingxenye ze-ellagic acid njenge-ellagitannins. Lezi zingxenye zamakhemikhali zihlanganiswa ne-ellagic acid-derivatives yi-gut microbiota.

Njengoba izimbali zamathumbu zibalulekile ekukhiqizeni ama-urolithin, inani lama-urolithin akhiqizwa emzimbeni lincike ohlotsheni lwezinto eziphilayo, okuyinto ebaluleke kakhulu eqenjini leClostridium leptum. Kubikwa ukuthi abantu abane-microbiota abacebile kumalungu aleli qembu bakhiqiza inani eliphakeme kakhulu lama-urolithin kunalabo abanezinye izimbali zamathumbu ezifana neBacteroides noma i-Prevotella.

Ama-Urolithin nawo akhiqizwa kusuka ku-punicalagin esiswini, njengama-ellagitannins, bese ekhishwa emchameni. Ukuhlola ukukhiqizwa kwe-urolithin emzimbeni, amazinga abo adinga ukubhekwa emchameni womuntu odle ukudla okunothe nge-ellagic acid noma okunezelwa ngama-urolithin njengesithako sayo esiyinhloko. Urolithin, kanye plasma, kungatholakala ngesimo glucuronides.

Ama-Urolithin atholakala ngokwemvelo ekudleni okuningana, yize kungenjalo wonke ama-molecule ama-urolithin angatholwa ekudleni. Lapho ukudla okune-ellagic acid sekudliwe, kuya ngezimbali zesisu ukwephula ama-ellagitannins kanye ne-punicalagin ngokuya phambili kuma-metabolites aphakathi nemikhiqizo yokugcina; ama-molecule we-urolithin.

Lawa ma-molecule asanda kuthola ukuthandwa futhi aqhubeka nokukhuphuka njengezithasiselo zokudla okuphezulu ngenxa yezinzuzo zawo zokulwa nesimila, ukulwa nokuguga, ukulwa nokuvuvukala, kanye nokuncishiswa kokuzilimaza. Ngaphezu kwalokho, ama-molecule e-urolithin athile ahlotshaniswa namazinga amandla athuthukisiwe njengoba anomthelela omkhulu empilweni ye-mitochondrial. Ukukhiqizwa kwamandla emzimbeni kuyinkqubo eyenzeka kwi-mitochondria, futhi nokwenza ngcono ukusebenza kwale organelle ngomunye wemisebenzi eminingi yama-Urolithins.

Amamolekyu Awaziwayo we-Urolithin

Ama-Urolithin abhekisele ngokuhlangana kuma-molecule ahlukene angokomndeni we-urolithin kodwa anezindlela ezahlukahlukene zamakhemikhali, amagama e-IUPAC, ukwakheka kwamakhemikhali nemithombo. Ngaphezu kwalokho, la mangqamuzana anokusebenzisa okuhlukahlukene kakhulu nezinzuzo emzimbeni womuntu ngakho-ke akhangiswa ngendlela ehlukile efomini lokwengeza.

Ama-Urolithins, ngemuva kocwaningo olunzulu, aziwa ngokuwohloka kulama-molecule alandelayo emzimbeni, noma kungenjalo okuningi okwaziwayo ngawo wonke ama-molecule athile:

● I-Urolithin A (3,8-Dihydroxy Urolithin)
● I-Urolithin A glucuronide
● Urolithin B (3-Hydroxy Urolithin)
● Urolithin B glucuronide
● Urolithin D (3,4,8,9-Tetrahydroxy Urolithin)

I-Urolithin A ne-Urolithin B, eyaziwa kakhulu njenge-UroA ne-UroB ngokulandelana, yi-metabolites eyaziwayo yama-Urolithins emzimbeni. Lawa amabili futhi ngama-molecule asetshenziswayo njengamanje kuma-supplements kanye ne-powders yokufaka ukudla.

Kanye egazini, i-Urolithin A ikhona njenge-Urolithin A glucuronide, kanti i-Urolithin B ingatholakala njenge-Urolithin B glucuronide. Ngenxa yalokhu, kukholakala ukuthi banemiphumela efanayo neyabandulelayo njengasezifundweni ze-vivo ezingenzekanga ngama-urolithin. Ukushoda kwezifundo ze-vivo kwenza kube nzima ukuhlola ukuthi ngabe i-UroA kanye ne-UroB glucuronides zinomphumela ohlukile yini kune-UroA kanye ne-UroB uqobo.

I-Urolithin A inenye into etholakala egazini, okuyi-Urolithin A sulfate. Yonke le mikhiqizo yenza imisebenzi yayo egazini bese isuswa ohlelweni ngomchamo.

I-Urolithin D ingenye i-molecule ebalulekile ekhiqizwa yimiphumela ye-gut microbiota, kepha-ke, akukho okuningi okwaziwayo ngemiphumela yayo nokusetshenziswa okungenzeka kube khona. Njengamanje, ayisetshenziswa kunoma iziphi izithasiselo noma ukufaka esikhundleni sokudla, ngokungafani nozakwabo, i-UroA ne-UroB. Ngaphezu kwalokho, imithombo yokudla ye-Urolithin D ayaziwa.

I-Urolithin A Powder Information Package

I-Urolithin A ayitholakali ngokwemvelo kusuka emithonjeni yokudla futhi ingeyeqembu lama-compounds aziwa ngokuthi ama-benzo-coumarins noma ama-dibenzo-α-pyrones. It is empeleni metabolized from ellagitannins to Urolithin A 8-Methyl Ether before being further broken down into Urolithin A. Lo mkhiqizo wokugcina utholakala ngobuningi efektri yethu yokukhiqiza ngohlobo lwe-Urolithin A powder. IMethylUrolithin A powder nayo iyatholakala ukuthi ithengwe ngobuningi uma kudingeka.

I-Urolithin A ayitholakali kumazinga afanayo, noma ngabe inamazinga afanayo okusetshenziswa kwezandulela zayo, kubantu abahlukile ngoba konke kuncike ekusebenzeni kwe-gut microbiota. Imetabolism ka-Urolithin A kukholakala ukuthi idinga uGordonibacter urolithinfaciens noGordonibacter pamelaeae kodwa abanye abantu abanalezi zinto basakhombisa ukuthi akunamthelela omkhulu ekukhiqizeni i-molecule.

I-Urolithin A inezici ezithile ezenza ukuthi ivelele kwezinye izinto, njengalezo ezishiwo kuthebula elingezansi.

CAS Inombolo1143-70-0
Ukuhlanzeka98%
Igama le-IUPACI-3,8-Dihydroxybenzo [c] chromen-6-eyodwa
omqondofana3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-one; 3,8-DIHYDRO DIBENZO- (B, D) PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-one; I-Castoreum pigment mina; Urolithin A; I-6H-Dibenzo (B, D) i-pyran-6-eyodwa, i-3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-one); i-urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) i-pyran-6-eyodwa
Formula YamamolekhulaC13H8O4
isisindo Yamamolekhula228.2
I-Melting Point> 300 ° C
InChI KeyI-RIUPLDUFZCXCHM-UHFFFAOYSA-N
IfomuSolid
ukubukekaI-Powder Ekhanyayo
Ukuphila okungapheleleAyaziwa
solubilityI-soluble ku-DMSO (3 mg / mL).
isitoreji IsimoIzinsuku Kuya Emavikini: Egumbini elimnyama, elomile ku-0 - 4 degrees C Izinyanga Kuya Eminyakeni: Ku-Freezer, kude neziphuzo ku -20 degrees C.
IsiceloUkusetshenziswa kokudla njengokufaka ukudla kanye nezengezo

Iphakethe Lolwazi Lwe-Urolithin B Powder

I-Urolithin B iyinhlanganisela ye-phenolic eqale ukukhiqizwa ngobuningi kusukela ngoJanuwari ka-2021. Ingatholwa ngokudla ukudla okuningana okuyimithombo yemvelo yama-ellagitannins angafakwa ku-Urolithin B. Kutholakale ukuthi inamandla isakhi sokulwa nokuguga ongasithenga ngobuningi ngesimo se-Urolithin B powder.

Izici ezahlukahlukene ze-Urolithin B powder etholakala enkampanini yethu yokukhiqiza zishiwo ngezansi:

CAS Inombolo1139-83-9
Ukuhlanzeka98%
Igama le-IUPACI-3-Hydroxy-6H-dibenzo [b, d] pyran-6-eyodwa
omqondofanaI-AURORA 226; Urolithin B; I-AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo [c] chromenone; 3-hydroxybenzo [c] chromen-6-one; 3-Hydroxy-benzo [c] chromen-6-one; 3-HYDROXY-6H-DIBENZO [B, D] PYRAN-6-ONE; 6H-Dibenzo (b, d) pyran-6-one, 3-hydroxy-; 3-Hydroxy-6H-benzo [c] chromen-6-one AldrichCPR
Formula YamamolekhulaC13H8O3
isisindo YamamolekhulaI-212.2 g / mol
I-Melting Point> 247 ° C
InChI KeyI-WXUQMTRHPNOXBV-UHFFFAOYSA-N
IfomuSolid
ukubukekaI-powder nsundu ekhanyayo
Ukuphila okungapheleleAyaziwa
solubilityIyancibilika ku-5mg / mL lapho kufudunyezwa, kucace uketshezi
isitoreji IsimoI-2-8 ° C
IsiceloIsengezo se-anti-oxidant ne-Pro-oxidant ngomsebenzi we-estrogenic.


Ngaphandle kwala ma-molecule amakhulu ama-Urolithins akhiwa ngenxa yezenzo ze-gut flora, kunama-molecule amaningi angabalamuli abakhiwa ngesikhathi sokuwohloka kwezandulela. Laba bantu abaphakathi bahlanganisa:

● I-Urolithin M-5
● I-Urolithin M-6
● I-Urolithin M-7
● I-Urolithin C (3,8,9-Trihydroxy urolithin)
● I-Urolithin E (2,3,8,10-Tetrahydroxy urolithin)

Akukho okuningi okwaziwayo ngalaba bantu abaphakathi njengamanje, kodwa-ke, olunye ucwaningo lunamandla okuthola izinzuzo nokusetshenziswa kwala ma-molecule e-Urolithin.

Isebenza kanjani i-Urolithins?

Ama-Urolithin, njengamanye ama-compounds asetshenziswa kuma-supplements, athinta izitho nezinhlelo ezahlukahlukene emzimbeni, ukukhiqiza imiphumela emihle. Indlela yokusebenza ye-Urolithins, bobabili u-A no-B, ingahlukaniswa ngamagatsha ayisithupha, futhi igatsha ngalinye linamandla okukhiqiza izinzuzo eziningi.

● Izakhiwo ze-Antioxidant
Inzuzo enkulu yokuba nezindawo zokulwa ne-antioxidant kuncishisiwe ukucindezeleka okwenziwe nge-oxidative emzimbeni. Ukucindezeleka okwenziwe nge-oxidative kubhekisa ekucindezelekeni kumaseli nezicubu emzimbeni ngenxa yokusabela kwamakhemikhali okukhiqiza izinhlanganisela ezingazinzile, ezaziwa nangokuthi ama-radicals amahhala. Lawa ma-radicals amahhala anamandla okuqhubeka okubamba iqhaza ekuphendukeni kwamakhemikhali okuguquguqukayo emzimbeni, umkhiqizo owonakalisa amaseli nezicubu.

Ama-Urolithin anciphisa lokhu kucindezeleka okwenziwa yi-oxidative, okuholela ekuvinjelweni kokulimala kwamaseli futhi kwenyuse amathuba okusinda kweseli. Le miphumela yenziwa yenzeka ngokuncipha kokukhiqizwa kwe-Intracellular Reactive Oxygen Species (iROS), okuluhlobo lwama-radicals amahhala. Ngaphezu kwalokho, izakhiwo ze-antioxidant ze-Urolithin A ne-Urolithin B nazo zivela ngokuncipha kwenkulumo ye-NADPH oxidase subunit, ebaluleke kakhulu ekuphendukeni kwamakhemikhali okuholela ekucindezelekeni kwe-oxidative.

Ukukhiqiza izakhiwo ze-antioxidant, ama-Urolithins futhi andisa ukubonakaliswa kwe-antioxidant heme oxygenase-1 nge-Nrf2 / ARE signway pathway. Lokhu kuzisiza ukuthi zingagcini ngokunciphisa izinhlanganisela eziyingozi kepha futhi zandisa ama-enzyme amahle akhuthaza izakhiwo ze-antioxidant.

Ama-Urolithins, lapho enikezwa amagundane anokulimala kobuchopho okwenziwe yi-LPS, avimbele ukusebenza kwe-microglial, noma ngamagama alula, ukwakheka kwesibazi nokuvuvukala okungakhuphula ingozi yokulimala unomphela kobuchopho. Lo mphumela wama-urolithin kukholakala ukuthi uyinhlanganisela yezakhi ze-antioxidant nezakhiwo ezilwa nokuvuvukala.

● Izakhiwo Zokuvikela Ukuvuvukala
Izici ezilwa nokuvuvukala zama-Urolithins zingenye zezizathu eziyinhloko zodumo lwayo olukhulayo emhlabeni wokungezelela. Indlela lezi zinhlanganisela, ikakhulukazi i-Urolithin A, i-Urolithin B, nefomu lazo le-glucuronides, zihluke kakhulu futhi zikhiqiza imiphumela ehluke ngokulinganayo.

Umphumela wokulwa nokuvuvukala we-Urolithin A no-Urolithin B unendlela efanayo ne-Non-Steroidal Anti-inflammatory Drugs noma i-NSAID efana ne-Ibuprofen ne-Aspirin. Ama-Urolithins ayaziwa ukuthi anomthelela ekuvimbeleni ukukhiqizwa kwe-PGE2 kanye nokubonakaliswa kwe-COX-2. Njengoba ama-NSAID evimbela ukubonakaliswa kokubili kwe-COX 1 ne-COX 2, kungaphethwa ngokuthi ama-Urolithins anomphumela wokulwa nokuvuvukala okhetha kakhulu.

Izici ezilwa nokuvuvukala ze-Urolithins kufakazelwe ukuthi azilwi nokuvuvukala emzimbeni kuphela kepha ziyakwazi nokuguqula umonakalo owenziwe ezithweni ngenxa yokuvuvukala kwesikhathi eside okuholele ekuhlulekeni kwesitho. Ocwaningweni lwakamuva olwenziwe ezinhlobonhlobo zezilwane, kutholakale ukuthi ukusetshenziswa kwe-urolithin kunamandla okunciphisa i-nephrotoxicity eyenziwe yizidakamizwa ngokuvimbela ukufa kwamangqamuzana e-renal nokuvuvukala.

Kutholakale ukuthi i-urolithin A powder, enikezwe ngomlomo, ibinomthelela wokuvimbela indlela yokuvuvukala kanye ne-proapoptotic cascade, yingakho, ivikela ukusebenza kwezinso. Lezi zakhiwo ze-Urolithin A kanye namanye ama-urolithin akhomba esikhathini esizayo lapho lezi zinhlanganisela zingasetshenziswa ngokwelapha kanye nokusetshenziswa kwazo njengama-supplements.

● Izakhiwo ze-Anti-Carcinogenic
Ama-Urolithins kukholakala ukuthi alwa ne-carcinogenic ngenxa yekhono lawo lokuba nemiphumela efana nokuboshwa komjikelezo wamaseli, ukuvinjelwa kwe-aromatase, ukufakwa kwe-apoptosis, ukucindezelwa kwesimila, ukukhuthazwa kokuzenzakalela komzimba, kanye nesescence, ukulawulwa kokubhaliwe kwe-oncogenes, ne-factor factor receptors. Le miphumela, uma ingekho, ingadala ukukhula okuphazamisayo kwamaseli womdlavuza. Izici zokuvimbela ze-Urolithins zifakazelwe, ikakhulukazi ngomdlavuza wesinye kanye nomdlavuza wamakholoni, lapho abacwaningi abaningi bebuthanela ukusetshenziswa kwama-Urolithins njengemithi yokuvikela umdlavuza wesinye.

Ucwaningo olwenziwe ngo-2018 lwacwaninga ngemiphumela ye-Urolithin endleleni ye-mTOR ngenhloso yokuthola inketho yokwelashwa komdlavuza wepancreatic. Umdlavuza wepancreatic uhlotshaniswa namazinga aphezulu okufa kwabantu, kepha ucwaningo lwakamuva lukhombisa ukuthi i-Urolithin kungenzeka ingagcini ngokwandisa izinga lokusinda kepha futhi ivimbele nokuxhunyelelwa kwamangqamuzana ezimila kwezinye izingxenye zomzimba, okuholele ekutheni kube nemastastasis. I-Urolithin A yafundwa ngokukhethekile futhi imiphumela yaqhathaniswa nemiphumela ekhiqizwa yirejimeni yokwelashwa ejwayelekile. Kuphethwe ukuthi i-Urolithin A ikhiqize imiphumela engcono uma isetshenziselwa ukuphatha umdlavuza we-pancreatic, kuzo zombili izimo; lapho isetshenziswa yodwa noma ngecebo lokwelashwa elijwayelekile.

Ngokucwaninga okuqhubekayo, izinzuzo ze-Urothilins zingaqukatha ngokuphelele ukwelashwa komdlavuza we-pancreatic.

● Izakhiwo ze-Antibacterial
Ama-Urolithin aziwa ngezindawo zawo zokulwa namagciwane futhi analo mphumela ngokuvimbela iziteshi zokuxhumana zama-microorganisms, angawavumeli ukuba ahambe noma athelele amaseli. Kukholakala nokuthi banezinto ezibulala ukhunta, yize indlela yokusebenza engakacaci okwamanje.

Kunamagciwane amabili ama-Urolithin anethonya elinamandla lokuvimbela kuwo, okuholela ekuvikelekeni komzimba womuntu. Lawa magciwane angama-malarial microbes kanye neYersinia enterocolitica, womabili abangela ukutheleleka okunzima kubantu. Indlela i-Urolithin enezakhi zokulwa namagciwane kungakhathalekile ukuthi umzimba unjani iyafana.

● Izakhiwo ze-Anti Estrogenic ne-Estrogenic
I-Estrogen iyi-hormone ebalulekile emzimbeni wesifazane, futhi ukwehla kwamazinga ayo kuhlotshaniswa nezimpawu ezinjengokugubha, ukushisa okushisayo, nokuncipha kwamathambo. Njengoba kunikezwe ukubaluleka kwehomoni, kunengqondo ukuthi kufakwa enye indawo esikhundleni sayo. Kodwa-ke, amahomoni angaphandle anemiphumela ethile emibi eyenza ukusetshenziswa kwawo kungathandeki.

Kodwa-ke, i-Urolithin A ne-Urolithin B zinesakhiwo esifanayo ne-endo native estrogen kanye nokuhlangana kwama-estrogen receptors emzimbeni. I-Urolithin A inobudlelwano obunamandla, ikakhulukazi i-alpha receptor ngokuqhathaniswa ne-beta receptor. Yize womabili la makhompiyutha enokufana kwesakhiwo ne-estrogen, ama-urolithin anezici zombili ze-estrogenic nezama-anti-estrogenic, ngokungafani ne-estrogen engapheli.

Ubuningi balo mphumela wama-Urolithins ubenza babe yindlela yokwelashwa engahle ibe khona yezinkinga ezithile ezivela lapho kunikezwa i-estrogen engaphandle yokwelapha izimpawu zokushoda kwe-estrogen.

● Amaphrotheni Glycation Inhibition
Amaprotheni glycation inqubo lapho i-molecule yoshukela iboshelwa kuphrotheni. Le nqubo ibonakala ngesikhathi sokuguga noma njengengxenye yezifo ezithile. Ama-Urolithin avimbela ukwengeza ushukela, ngakho-ke kubangela imiphumela yokulwa ne-glycation. Ngaphezu kwalokho, zivimbela ukwakheka kokuthuthuka kwe-glycation endproducts, okuqoqeka okuyisinyathelo esibalulekile se-pathophysiological ekwakheni isifo sikashukela.

Izinzuzo ze-Urolithins

Ama-Urolithin anezindlela ezahlukahlukene zokusebenza ukukhiqiza izinzuzo ezahlukahlukene zokuzivikela emzimbeni womuntu. I-Urolithin A powder ne-Urolithin B powder isiza ekwenzeni izithasiselo ezidumile ngenxa yezinzuzo zezithako eziyinhloko. Zonke izinzuzo zalezi zinhlanganisela zamakhemikhali zisekelwa ubufakazi besayensi, futhi kwenziwa olunye ucwaningo ukuxhasa ukwengezwa kwama-Urolithins emihlahlandlela yokwelashwa kwezifo eziningana.

Izinzuzo zalezi zinhlanganisela, ngokususelwa kuzinqubo ezibalulwe ngenhla, zifaka:

● Izakhiwo ze-Antioxidant
Ama-Urolithin akhishwa ekudleni okunothile kwama-ellagitannins okwaziwa ngokwawo ukuthi acebile ngama-antioxidants. Umthombo wokudla ovame kakhulu wama-ellagitannins ne-ellagic acid ngamahalananda, futhi futhi angumthombo omkhulu wama-antioxidants. Kodwa-ke, kubalulekile ukuhlukanisa ukuthi izakhiwo zokulwa nomthombo wokudla kanye nama-urolithin ziyefana noma uma enye inamandla aphezulu kunenye.

Ucwaningo lokuqala luka-Urolithin A no-Urolithin B lukhombisa ukuthi imiphumela yokulwa ne-antioxidant yalokhu yayingaphansi izikhathi eziphindwe ngama-42 kunalezo zesithelo uqobo, yingakho kusikisela ukuthi lezi zinhlanganisela zamakhemikhali ngeke zenzele izithako ezinhle zezithasiselo.

Kodwa-ke, ucwaningo lwakamuva olunendlela ehlukile yokuhlaziya lukhombisa ukuthi i-Urolithin A ne-B zombili zisebenza kahle futhi zinezinto ezinamandla zokulwa nama-antioxidant ezizolwa nemiphumela yengcindezi ye-oxidative. Lapho kusetshenziswa indlela efanayo yokuhlaziya wonke ama-urolithin ukubona ukuthi yikuphi okunamandla kakhulu, i-Urolithin A yagqama. Imiphumela yabe seyenziwa kabusha ocwaningweni olufanayo no-Urolithin A ehola ngamandla, futhi.

Eqinisweni, esinye sezifundo sigxile ekuhloleni izakhiwo ze-antioxidant zalezi zinhlanganisela zamakhemikhali ngokuhlola ikhono lazo lokulwa nengcindezi ye-oxidative. Ngenhloso yalolu cwaningo, abacwaningi bafaka ingcindezi kumaseli e-neuronal futhi lapho bedalulwa kuma-Urolithins, ikakhulukazi i-Urolithin B, baqaphela ukwehla okuphawulekayo kwengcindezi kanye nokusinda okwenyuka kwamaseli e-neuronal.

● Izakhiwo Zokuvikela Ukuvuvukala
Izici ezilwa nokuvuvukala ze-Urolithins zikhiqiza izinzuzo eziningana, konke okufakazelwe ngokwesayensi.

Umphumela we-1
Ikhambi elenzelwe ukwelashwa kukamalaleveva elisetshenziswa kakhulu ezindaweni ezithile zasemakhaya lihilela ukusetshenziswa kwePomegranate. Abaphenyi bazama ukuqonda umthelela omuhle waleli khambi ekwelapheni umalaleveva ngokuhlanganisa imiphumela nemiphumela yama-Urolithins ahlanganiswe esiswini kusuka kupomegranati.

Kwenziwa ucwaningo lokuhlola umphumela wama-Urolithins ekwelapheni umalaleveva ngokuveza amaseli we-monocytic one-Urolithins. Lolu cwaningo luthole ukuthi izinhlanganisela zamakhemikhali zivimbela ukukhishwa kwe-MMP-9, okuyi-metalloproteinase ebalulekile ekwakhiweni nasekutholeni isifo sikamalaleveva. Ukuvinjelwa kwenkomponi kuvimbela umalaleveva ekubeni yi-pathogenic emzimbeni, yingakho kukholakala ukuthi kunomthelela wokulwa nemalariya.

Imiphumela yocwaningo iphinde ikhombise ukuthi ama-Urolithins avimbela ukubonakaliswa kwe-mRNA kwamagciwane e-malarial, okuholele ekuvinjelweni okuqhubekayo kwamandla we-microorganisms okubanga ukutheleleka. Imiphumela yalolu cwaningo ifakazela ukuthi imiphumela ezuzisayo yamakhambi enziwe afaka phakathi ihalananda kungenxa yemiphumela ye-urolithin.

Umphumela kuma-Endothelial Cell
I-atherosclerosis yisimo esivamile esiholela ekuhlambalazeni kwenhliziyo nasezikhungweni ze-myocardial infarctions. Izici ezimbili ezijwayelekile ngemuva kokuthuthuka kwe-atherosclerosis ukungasebenzi kahle kwe-endothelial nokuvuvukala. Ucwaningo lwamuva luzamile ukufakazela ukuthi izakhiwo ezilwa nokuvuvukala ze-Urolithin zingakwazi ukuvimbela ukungasebenzi kahle kwe-endothelial, ngakho-ke, ukuphatha ukwakheka kwe-atherosclerosis kanye nentuthuko.

I-Urolithin A itholwe ngabaphenyi ukuthi inesenzo esiphakeme kakhulu sokulwa nokuvuvukala phakathi kwawo wonke ama-urolithin. Ucwaningo lwakamuva lugxile kumaseli endothelial womuntu afakwa ne-LDL ene-oxidized, imfuneko yokwakheka kwe-atherosclerosis, kanye nokugxilwa okuhlukile kwe-Urolithin A. Abaphenyi bathole ukuthi i-Urolithin A evimbele i-nitric oxide synthase futhi yehlisa ukubonakaliswa kwe-I-CAM, okwaholela ekutheni ukunciphisa ukuvuvukala nokuncipha kwekhono lamaseli, ikakhulukazi ama-monocyte okunamathela kumaseli endothelial, ngokulandelana. Ukuncipha kokubambelela kwe-monocytic kunciphisa ukungasebenzi kahle kwe-endothelial.

Ngaphezu kwalokho, i-Urolithin A itholakale inciphisa ukubonakaliswa kwe-tumor necrosis factor α, i-interleukin 6, ne-endothelin 1; wonke ama-cytokines ahlasela ukuvuvukala.

Umphumela kuma-Fibroblasts ku-Colon
IColon ivezwa ngamagciwane angaphandle kanye nezakhi zokudla ezikwenza kube sengozini yokuvuvukala, okuthi ngokuhamba kwesikhathi kuholele ezindabeni eziningi zezempilo. Njengoba i-Urolithin A ne-Urolithin B zikhiqizwa yizimbali zamathumbu, kubalulekile ukwazi imiphumela yazo kuqala emzimbeni owakhiwe.

Ukufunda ngemiphumela yama-Urolithins kumaseli we-colon nakuma-fibroblast, abacwaningi benze ucwaningo lapho ama-fibroblast evezwa khona kuma-cytokines ahlasela ukuvuvukala abese e-Urolithins. Njengoba kushiwo ngenhla, kwatholakala ukuthi ama-Urolithins avimbela ukunamathela kwe-monocyte kanye nokufuduka kwe-fibroblast ukuvimbela ukuvuvukala kukholoni.

Ngaphezu kwalokho, kwatholakala ukuthi ama-Urolithins ayevimbela ukwenziwa kwe-NF-κB factor, ebalulekile ekulawuleni ukuvuvukala. Eqinisweni, abacwaningi bakholelwa ukuthi lokhu kuyimbangela eyinhloko yezakhiwo ezilwa nokuvuvukala kwama-urolithin.

● Izakhiwo ze-Anti-Carcinogenic
Ama-Urolithin ahlotshaniswa nezindawo ezilwa nomdlavuza, futhi nendlela yalezi zakhiwo ishiwo ngenhla. Kodwa-ke, izinzuzo zalezi zakhiwo zishiwo ngezansi:

1. Ukuvikelwa okuvela kuCancer ye-Prostate
Ukutholwa kwama-Urolithin emzimbeni kuvame ukwenziwa kusetshenziswa igazi noma umchamo; kodwa-ke, zingatholakala kuwo womabili amakholoni abesilisa nabesifazane kanye nendlala yesinye yabesilisa.

Njengomphumela walokhu okutholakele, abacwaningi bazama ukuhlola ukuthi ingabe izinzuzo zamakhemikhali ahlanganisiwe ziyabonakala ku-prostate gland njengoba zinjalo kukholoni. Ngakho-ke, kwenziwa isifundo, imiphumela yakhona efakazela ukuthi ama-Urolithin anomthelela wokuvikela endlaleni yesinye.

Kutholakale ukuthi u-Urolithin A no-Urolithin B, kanye no-Urolithin C no-Urolithin D bavimbe i-enzyme ye-CYP1B1 endlaleni yesinye. Le enzyme ilitshe le-chemotherapy futhi yayivinjelwe kakhulu yi-Urolithin A, uma iqhathaniswa namanye ama-urolithin. Baphinde bavimbela i-CYP1A1, kepha-ke, kwakudingeka ukuthi kube nokuhlungwa okuphezulu kwama-urolithin ukukhiqiza lowo mphumela.

Olunye ucwaningo lwenziwa ukutadisha imiphumela yokuvikela indlala yesinye ye-Urolithins. Kutholakale ukuthi i-Urolithin A ibinomthelela omelene nomdlavuza kumdlavuza wendlala yabesilisa ngazo zombili, izindlela ezizimele ze-p53 kanye ne-p53.

I-2.Topoisomerase 2 ne-CK 2 yokuvimbela
Ama-Urolithin anezinto ezilwa nomdlavuza ngokuvinjelwa kwezindlela eziningana zamangqamuzana eziholela ngqo noma ngokungaqondile ekuvinjelweni kokukhula komdlavuza. I-enzyme ye-CK2 iyi-enzyme ebalulekile ebamba iqhaza ezindleleni zamangqamuzana, nomsebenzi wawo omkhulu ukukhuthaza ukuvuvukala nomdlavuza.

Ama-Urolithin avimbela izindlela ezahlukahlukene zokufinyelela enzyme etholakala yonke indawo, i-CK2 ekugcineni ivimbele umphumela wayo, njengezakhiwo zayo ezikhuthaza umdlavuza. I-Urolithin A ikhonjiswe njenge-CK2 inhibitor enamandla, e-silico.

Ngokufanayo, iTopoisomerase 2 inhibition kukholakala ukuthi inemiphumela yokulwa nomdlavuza. Eqinisweni, le ndlela isetshenziswa ngamanye ama-chemotherapy agents anjengeDoxorubicin. Ocwaningweni lwakamuva, kutholakale ukuthi i-Urolithin A inamandla amakhulu kuneDoxorubicin ekuvimbeleni iTopoisomerase 2, yingakho, ifuna ukwengezwa kwayo ezinkombandlela zamanje zokwelashwa komdlavuza othile.

● Izakhiwo ze-Antibacterial
Izici ezilwa namagciwane ze-Urolithins zincike kwi-Quorum Sensing Inhibition esusa amandla we-microorganism ukuxhumana, ukuhambisa, nokwakha izinto ezinobungozi. Kuyindlela ebalulekile yokusinda kwamagciwane, futhi ukuvinjelwa kwawo yi-Urolithins kuyabulala amagciwane.

Impahla esemqoka elwa namagciwane ye-Urolithin yikhono layo lokuvikela amathumbu ekukhuleni kweYersinia enterocolitica. Eqinisweni, ama-Urolithins ahlotshaniswa nokushintshashintsha kwezimbali zesisu, izimbali ezifanayo ezibhekele ukukhiqizwa kwazo kuqala. Lokhu kubaluleke kakhulu ngoba yizinto ezithile kuphela ezimbali ezingakhuphula ukukhiqizwa kwama-Urolithins.

● Izakhiwo ze-Anti Estrogenic ne-Estrogenic
Ama-Urolithin abopha ama-Estrogen receptors futhi akhiqize zombili, izakhiwo ze-estrogenic kanye ne-anti-estrogenic. Lokhu kuyenza ibe yikhandidethi elihle le-Selective Estrogen Receptor Modulators noma ama-SERMs, indlela esemqoka yokuba nomthelela omuhle endaweni eyodwa yomzimba kanye nomphumela ovimbela kwenye indawo yomzimba.

Kwesinye sezifundo ezenziwe ngemiphumela yama-urolithin kuma-estrogen receptors, kutholakale ukuthi, ikakhulukazi i-urolithin A, ivimbela ukubonakaliswa kofuzo kwamaseli omdlavuza we-end-endometrium we-ER, okuholele ekucindezelweni komdlavuza we-endometrial. I-Endometrial hypertrophy ingumphumela ojwayelekile we-estrogen engaphandle kokuthunyelwe kwe-neoplasia njengabesifazane abathatha ukwelashwa okufaka esikhundleni se-hormone, futhi ukusetshenziswa kwama-urolithins kukholakala ukuthi kunomthelela wokuvikela ku-endometrium. Kodwa-ke, olunye ucwaningo ludinga ukwenziwa ngaphambi kokuthi ama-Urolithins abe yimithi elandelayo ye-SERM.

● Amaphrotheni Glycation Inhibition
Ukuba khona kwemikhiqizo yokuphela kokuhamba phambili kwe-glycation kuwuphawu lwe-hyperglycemia ebeka abantu phambili ekulimaleni kwenhliziyo nemithambo yesifo sikashukela noma isifo i-Alzheimer's. I-Urolithin A ne-Urolithin B zikhonjisiwe ukuthi zinomphumela we-anti-glycation ovimbela ukuthukwa kwenhliziyo futhi wehlise kakhulu ubungozi be-neurodegeneration kakhulu.

Ngakho-ke, ukuvinjelwa kwamaprotheni glycation yi-Urolithins kukholakala ukuthi kunemiphumela yomzimba yokuvikela inhliziyo kanye ne-neuroprotective.

Izinzuzo ze-Urolithin A zibalulwe lapha ngezansi:

● Yandisa isikhathi sokuphila
Ukuguga, ingcindezi kanye nokuphazamiseka okuthile kungalimaza i-mitochondria, ebaluleke kakhulu ekukhiqizweni nasekusebenziseni okujwayelekile komzimba. Ngaphezu kwalokho, i-mitochondria ivame ukubizwa ngokuthi 'yindawo yamandla yeseli', okusho ukubaluleka kwayo ekusebenzeni okujwayelekile kweseli. Ngakho-ke, noma yikuphi ukonakala kwaleli gumbi lamandla kuzothinta kabi iseli futhi kunciphise isikhathi sokuphila kwalo kakhulu.

Ama-Urolithins enza umphumela othize owaziwa ngokuthi yi-mitophagy ovumela umzimba ukuthi ususe i-mitochondria eyonakele, noma ngabe kungasizathu sini somonakalo, futhi wandise isikhathi sokuphila. Ngokuya ngobukhulu bomonakalo, i-mitochondria ingahle isetshenziswe kabusha ukuze kwenziwe izakhamzimba nokukhiqizwa kwamandla.

● I-Neuroprotective
Njengoba kushiwo ngenhla, ama-urolithin anezinto ezilwa nokuvuvukala futhi yilezi zakhiwo ezikhuthaza ukwakheka kwamangqamuzana e-neuronal ebuchosheni, okunomphumela omuhle ekuqondeni nasekugcinweni kwememori. Ngaphezu kwalokho, i-Urolithin A ivikela i-neurodegeneration ebonwa ngesifo i-Alzheimer's, yingakho, imiphumela ye-neuroprotective.

● Vimbela Umdlavuza Wendlala Yesinye
I-Urolithin A inezinto ezilwa nomdlavuza kepha iyabonakala ikakhulukazi esimweni somdlavuza wendlala yabesilisa, ngezifundo eziningana ezikhuthaza ukusetshenziswa kwepomegranate neminye imithombo yama-Urolithins ekwelapheni umdlavuza weProstate.

● Yelapha Ukukhuluphala
I-Urolithin A inemiphumela yokulwa nokukhuluphala njengoba ingavimbeli nje kuphela ukunqwabelana kwamaseli anonile emzimbeni kepha futhi ivimbela omaka ababhekele i-adipogenesis. Ocwaningweni olwenziwe ezinhlobonhlobo zezilwane, kutholakale ukuthi i-Urolithin A inomthelela ophakeme kwi-T3 hormone ye-thyroid, okuholela ekusetshenzisweni kwamandla kwamandla kumagundane. Lokhu kuheha i-thermogenesis futhi kubangele ukuthi amafutha ansundu ancibilike, kuyilapho amafutha amhlophe efakwa ku-browning.

Esicwaningweni esifanayo, kutholakale ukuthi i-URolithin A inethonya lokuvimbela ukukhuluphala ngisho nakamagundane abondliwe ukudla okunamafutha aphezulu. Lokhu kukhombisa isethembiso esikhulu maqondana nokukhuluphala futhi abaphenyi bacele ukuthi izicelo zabantu zalokhu okutholakele zikwazi ukusebenzisa le nhlanganisela ukulwa nobhadane lokukhuluphala.

Izinzuzo ze-Urolithin B zingezansi:

● Vimbela ukulahleka kwemisipha
Urolithin B wabelana ngezinzuzo ezithile ze-Urolithin A kepha unenzuzo eyodwa ethize, ehlukile kuye uqobo. I-Urolithin B yaziwa ngokuvimbela ukulahleka kwemisipha kuzimo zombili zomzimba nezezifo. Ngaphezu kwalokho, ithuthukisa ukukhula kwemisipha yamathambo ngokwandisa amaprotheni synthesis emisipheni.

Kubuye kube nomphumela wokuvimbela i-muscle atrophy njengoba kuboniswe ocwaningweni olwenziwe kumagundane ayenqunywe imithambo yegazi. Lokhu bekungaholela ekuthanjeni kwemisipha kepha amagundane afakwa amaphampu ama-osmotic amancane aqhubeka abanikeza u-Urolithin B. Kutholakale ukuthi la magundane acindezelwe indlela yawo ye-ubiquitin-proteasome, okwaholela ekusweleni okucacile kwe-muscle atrophy yize kunesigaba se-sciatic nerve .

Isilinganiso se-Urolithins

Ama-Urolithin asuselwa kumakhemikhali emvelo futhi izithako zawo zibhekwa njengokubekezelela kahle kungekho ntatheli yobuthi. Kodwa-ke, kubalulekile ukukhumbula ukuthi lezi zinhlanganisela zisacwaningwa futhi zinemikhawulo yesilinganiso okufanele ilandelwe ngokuqinile.

● Urolithin A
Ngemuva kocwaningo olunzulu ngezinzuzo ze-Urolithin A, kube nezifundo zocwaningo eziningana ezenziwa ukuhlola isilinganiso esifanele sale nhlanganisela yamakhemikhali. Ucwaningo lwe-Absorption, Digestion, Metabolism, kanye ne-Elimination lwenziwa ukuhlaziya izici zekhompiyutha.

Ucwaningo lwehlukaniswe kabili, kuye ngenani lezinsuku, kwatholakala ukuthi ucwaningo lwezinsuku ezingama-28 no-0, 0.175, 1.75, no-5.0% we-Urolithin A exutshwe ekudleni nasekufundweni kwezinsuku ezingama-90 no-0, 1.25, I-2.5, ne-5.0% i-Urolithin A exutshwe ekudleni ayikhombisanga ushintsho kumapharamitha womtholampilo, i-chemistry yegazi, noma i-hematology, futhi ayichazanga izindlela ezithile ezinobuthi. Zombili lezi zifundo zazinomthamo ophakeme kakhulu ohlolwe ku-5% UA ngesisindo ekudleni okwaholela emithamo elandelayo; I-3451 mg / kg BW / usuku kwabesilisa ne-3826 mg / kg BW / ngosuku kwabesifazane esifundweni somlomo sezinsuku ezingama-90.

● Urolithin B
Ngokufana ne-Urolithin A, i-Urolithin B yafundwa kabanzi ukuhlola isilinganiso esifanele. Yize kubalulekile ukuthi uqaphele ukuthi izifundo zigxile esilinganisweni esiphephile ukufeza ukwanda okuhle kwemisipha. Lo mthamo utholwe u-15uM, kubo bobabili ubulili, ngaphandle kwesisindo.

● Urolithin A 8-Methyl Ether
Le nhlanganisela iyasetshenziswa futhi, ikakhulukazi ngoba iphakathi nesikhathi sokukhiqizwa kwe-Urolithin A. Kodwa-ke, alukho ucwaningo olwanele olwenziwe ngomthamo ofanele onqunyelwe le Urolithin ethile.

Imithombo Yokudla yama-Urolithins

Ama-Urolithin awatholakali ngokwemvelo kunoma yimuphi umthombo wokudla, noma kunjalo, atholakala njengama-ellagitannins. Lawa ma-tannin ahlahlela ku-ellagic acid, aqhubekela phambili ehlanganisa i-Urolithin A 8-Methyl ether, bese eya ku-Urolithin A, bese kuthi ekugcineni, i-Urolithin B. Ukudla okunothile kuma-Urolithins yilawa:

Umthombo wokudlaI-Acid e-Ellagic
Izithelo (mg / 100g isisindo esisha)
Amajikijolo150
Amajikijolo amnyama90
Ama-Boysenberries70
Ama-Cloudberry315.1
emhlophe> 269.9
Ama-raspberries270
URose okhalweni109.6
Ama-Strawberries77.6
Ijamu le-Strawberry24.5
Amajikijolo aphuzi1900
Amantongomane (mg / g)
pecans33
Ama-Walnuts59
Iziphuzo (mg / L)
Ujusi wamapomegranate811.1
I-cognac31-55
Iwayini elibomvu elineminyaka engama-oak33
I-Whisky1.2
Imbewu (mg / g)
Amajikijolo amnyama6.7
Amajikijolo abomvu8.7
Ama-Boysenberries30
i-Mango1.2


Njengoba kubonakala etafuleni, ama-Cloudberries yizithelo ezine-Ellagitannins ephakeme kakhulu ne-Ellagic acid, nePomegranate njengesibili esiseduze. Ipomegranate Juice, noma kunjalo, empeleni ingumthombo onamandla ngokwengeziwe, cishe kathathu onamandla njenge-Cloudberries.

Kubalulekile ukuthi uqaphele ukuthi okuqukethwe kwe-ellagic acid kwizinsiza zokudla akulingani nenani elifanayo le-urolithin emzimbeni. Ukutholakala kwama-URolithins kuncike kakhulu kwi-gut microbiota yawo wonke umuntu.

Kungani Kufanele Uthenge Ku-Factory Yethu Yomkhiqizi?

I-Urolithin Powder A ne-Urolithin Powder B ziyatholakala ngobuningi, embonini yethu yokukhiqiza ehlanganisa ukukhiqizwa, ucwaningo, ukuthuthukiswa kanye nokuthengiswa kwalezi zithasiselo. Imikhiqizo yethu yenziwa ngokusebenzisa ukucacisa okukhulu ukulandela yonke imihlahlandlela yezokuphepha, eqinisekisa ikhwalithi ephezulu nokuphepha komkhiqizo wokugcina. Yonke imikhiqizo iyacwaningwa ngaphambi kokukhiqizwa futhi ihlolwe kahle ngesikhathi nangemva kokukhiqizwa ukuhlangabezana nezindinganiso zakho zekhwalithi.

Ngemuva kokukhiqizwa, imikhiqizo ihlolwa kumalebhu ethu isikhathi esisodwa ukuhlola ikhwalithi, amandla, nokuphepha kwama-Urolithin powders neminye imikhiqizo. Uma sekulungele ukusatshalaliswa, imikhiqizo iyaqoqwa futhi igcinwe ezindaweni ezifanele, ezingeni lokushisa elifanele ngenkathi ilandela yonke imihlahlandlela yokuqinisekisa ukuthi umkhiqizo osezingeni eliphakeme ufinyelela kuwe. I-Urolithin powders ayivezwa yilanga ngesikhathi sokuhamba, ukupakisha, noma ukugcinwa njengoba lokho kungalimaza umkhiqizo wokugcina.

Ukuthenga i-Urolithin A powder kanye ne-Urolithin B powder kusuka efektri yomenzi wethu kuqinisekisa umkhiqizo osezingeni eliphakeme ngamanani aphansi kakhulu.

Izikhombo:

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  2. UGuada M, uGanugula R, uVadhanam M, uRavi Kumar MNV. I-Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity ngokuvimbela ukuvuvukala kwe-renal kanye ne-apoptosis kwimodeli yegundane lokuhlola. UJ Pharmacol Exp Ther. 2017; 363 (1): 58-65. i-doi: 10.1124 / jpet.117.242420.
  3. UJuan Carlos Espín, Mar Larrosa, María Teresa García-Conesa, uFrancisco Tomás-Barberán, "Ukubaluleka Kwezinto Eziphilayo ze-Urolithins, i-Gut Microbial Ellagic Acid-Derives Metabolites: Ubufakazi Kuze Kube Manje", Ubufakazi Obusekelwe Ebufakazini Obusebenzisayo kanye Nomuthi Ohlukile, vol. 2013, i-Article ID 270418, amakhasi ayi-15, 2013. https://doi.org/10.1155/2013/270418.
  4. U-Lee G, iPark JS, uLee EJ, u-Ahn JH, uKim HS. Izindlela zokulwa nokuvuvukala kanye ne-antioxidant ye-urolithin B ku-microglia esebenzayo. I-Phytomedicine. 2019; 55: 50-57. i-doi: 10.1016 / j.phymed.2018.06.032.
  5. UHan QA, uYan C, u-Wang L, u-Li G, u-Xu Y, u-Xia X. Urolithin A unciphisa ukungasebenzi kahle kwe-ox-LDL-endothelial ngokwengxenye ngokuguqula indlela ye-microRNA-27 ne-ERK / PPAR-γ. Mol Nutrut Ukudla Res. 2016; 60 (9): 1933-1943. i-doi: 10.1002 / mnfr.201500827.