i-α-ketoglutaric

ICofftek inamandla okukhiqiza ngobuningi kanye nokuhlinzekwa ngeCalcium 2-oxoglutarate ne-Alpha-Ketoglutaric Acid ngaphansi kwesimo se-cGMP.

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Yini i-Alpha-Ketoglutaric Acid (328-50-7)?

I-Alpha-ketoglutaric acid iyinhlanganisela yebhayoloji etholakala ngokwemvelo emzimbeni womuntu. Futhi etholakala njengesengezo sokudla, i-alpha-ketoglutaric acid idlala indima enkulu kumjikelezo weKrebs (uchungechunge lokuphendula kwamakhemikhali okusetshenziselwa ukukhipha amandla agciniwe). Izithako ze-alpha-ketoglutaric acid kuthiwa zinikela ngezinzuzo ezahlukahlukene zezempilo, kufaka phakathi ukusebenza kwezemidlalo okuthuthukisiwe kanye nokwenza ngcono umzimba.

Izinzuzo ze-Alpha-Ketoglutaric Acid (328-50-7)

Uma kushiwo lokho, izifundo ezimbalwa zokuqala ziveze izinzuzo ezingaba khona ze-alpha-ketoglutaric acid supplementation. Nakhu okushiwo olunye ucwaningo lwamanje:
①Isifo Sezinso Esingapheli
Alpha-ketoglutaric acid has been used since the late-1990s to help break down and absorb protein in people on hemodialysis who require a low-protein diet. Recent evidence suggests that it may also delay the need for dialysis in people with advanced chronic kidney disease (CKD).

(1)↗

Umthombo Othembekile

I-PubMed Central

Isizindalwazi esihlonishwa kakhulu esivela ku-National Institutes of Health
Iya kumthombo

According to a 2017 study in the journal PLoS One, researchers identified and followed 1,483 people with advanced CKD who used an alpha-ketoglutaric acid supplement called Ketosteril. The average duration of the follow-up was 1.57 years.
Compared to a matched set of individuals who didn't take the supplement, those who did were less likely to require long-term dialysis. The benefits extended only to those who took more than 5.5 tablets per day, indicating the effects were dose-dependent.
Despite the positive findings, it is unclear what role alpha-ketoglutaric acid played in comparison to the supplement's other active ingredients. Further research is needed.

HealthImpilo Yamathumbu
Alpha-ketoglutaric acid supplements are believed to be anticatabolic, meaning that it slows or prevents or catabolism (the breakdown of tissues). By definition, a catabolic process is opposite to an anabolic process (in which tissues are built).
A 2012 study in the Italian Journal of Animal Science reported that alpha-ketoglutaric acid prevented the breakdown of the intestines in lab rats fed a protein-free diet for 14 days. Rather than experiencing damage to the finger-like villi of the intestines—the expected outcome—the rats fed alpha-ketoglutaric acid had no visible damage compared to rats that weren't.
Moreover, the rats provided the supplements were able to maintain normal growth despite the total lack of protein. Higher doses conferred to even better results.
The findings appear to support alpha-ketoglutaric acid's anticatabolic effects. In addition to its application in chronic kidney disease, alpha-ketoglutaric acid may also aid people with intestinal toxemia and malabsorption disorders like celiac disease. Further research is needed.

Ukusebenza kwe-Athletic
By contrast, the anticatabolic effects of alpha-ketoglutaric acid appear to fall short when used for the purpose of muscle growth and athletic performance.
According to a 2012 study in the Journal of the International Society of Sports Nutrition, alpha-ketoglutaric acid had no tangible effect on either muscle strength or exercise endurance in 16 men tasked with a resistance training workout.

(2)↗

Umthombo Othembekile

I-PubMed Central

Isizindalwazi esihlonishwa kakhulu esivela ku-National Institutes of Health
Iya kumthombo

For this study, half of the men were given 3,000-milligrams (mg) of alpha-ketoglutaric acid, while the other half were given a placebo 45 minutes before doing bench press and leg press exercises. The following week, the supplements were flipped, with each half getting the alternate drug.
Athletic performance was based on the total load volume (TLV) of the exercises performed in tandem with pre- and post-exercise heart rates. What these findings demonstrate is the absence of catabolic response is not the same thing as an anabolic response, especially among athletes.

I-Alpha-Ketoglutaric Acid (328-50-7) isebenzisa?

In heart surgery, alpha-ketoglutaric acid is sometimes delivered intravenously (into a vein) to reduce damage to the heart muscle due to the reduced blood flow. Doing so may also improve blood flow to the kidney following the surgery.
Its use as a supplement is far less certain. Alternative practitioners believe that alpha-ketoglutaric acid can treat or prevent a wide variety of health conditions, including:
  • Lolu ngwengwezi lwakheka
  • Isifo sezinso ezingapheli
  • I-hepatomegaly (isibindi esikhulisiwe)
  • I-toxemia yamathumbu
  • I-thrush yomlomo
  • Kwamathambo
  • I-tendinopathy
  • Izifo zemvubelo
Because of its role in releasing stored energy, alpha-ketoglutaric acid is often marketed as a sports performance supplement. Some proponents even assert that the supplement's antioxidant effects can slow aging.

(3)↗

Umthombo Othembekile

I-PubMed Central

Isizindalwazi esihlonishwa kakhulu esivela ku-National Institutes of Health
Iya kumthombo

As is often the case with supplements that claim to treat multiple unrelated conditions, the evidence supporting these claims is weak. Some, like the supplement's "anti-aging" properties (based largely on a 2014 study involving nematode worms), border on the improbable.

I-Alpha-Ketoglutaric Acid (328-50-7) isilinganiso

Alpha-ketoglutaric acid supplements are available in tablet, capsule, and powder formulations and can be readily found online or in stores specializing in dietary supplements.
There are no universal guidelines for the appropriate use of alpha-ketoglutaric acids. Supplements are typically sold in dosages ranging from 300 milligrams (mg) to 1,000 mg taken once daily with or without food. Doses of up to 3,000 mg have been used in studies with no adverse effects.

I-Alpha-Ketoglutaric Acid (328-50-7) imiphumela emibi engaba khona

Alpha-ketoglutaric acid is considered safe and well-tolerated. Studies investigating the effects of alpha-ketoglutaric acid reported few adverse symptoms after three years of use.
As a compound made from non-essential amino acids, alpha-ketoglutaric acid is not a substance on which you can readily overdose. Any excess in the body will either be excreted in urine or broken down into the basic amino acid building blocks for other purposes.

(4)↗

Umthombo Othembekile

I-PubMed Central

Isizindalwazi esihlonishwa kakhulu esivela ku-National Institutes of Health
Iya kumthombo

With that said, the safety of alpha-ketoglutaric acid in pregnant women, nursing mothers, and children has not been established. This includes children with rare metabolism disorders such as alpha-ketoglutarate dehydrogenase deficiency (in which alpha-ketoglutaric acid levels are abnormally elevated).

I-Alpha-Ketoglutaric Acid powder iyathengiswa (Ungayitholaphi i-Alpha-Ketoglutaric Acid powder ngobuningi)

Inkampani yethu ithokozela ubudlelwane besikhathi eside namakhasimende ethu ngoba sigxile ekusebenzeni kwamakhasimende nokunikezela ngemikhiqizo emihle. Uma unentshisekelo ngomkhiqizo wethu, siyavumelana nezimo nge-oda eyenziwe ngokwezifiso ukuze ivumelane nesidingo sakho esithile nesikhathi sethu sokuhola esisheshayo kuma-oda siqinisekisa ukuthi uzowunambitha kakhulu umkhiqizo wethu ngesikhathi. Siphinde sigxile nezinsizakalo ezingezwe zenani. Sitholakala ngemibuzo yensiza nolwazi lokuxhasa ibhizinisi lakho.
We are an professional Alpha-Ketoglutaric Acid powder supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

Izikhombo:

  1. U-Abrahams JP, uLeslie AG, uLutter R, uWalker JE. Ukwakheka ku-2.8 Ukulungiswa kwe-F1-ATPase kusuka enhliziyweni yezinkomo i-mitochondria. Imvelo. 1994; 370: 621-628. i-doi: 10.1038 / 370621a0.
  2. Ama-Alpers DH. I-Glutamine: ingabe idatha iyayisekela imbangela yokwengezwa kwe-glutamine kubantu? I-Gastroenterology. 2006; 130: S106-S116. i-doi: 10.1053 / j.gastro.2005.11.049.
  3. U-Ashkanazi J, uCarpertier Y, uMichelsen C. Imisipha nama-plasma amino acid kulandela ukulimala. U-Ann Surg. 1980; 192: 78-85. i-doi: 10.1097 / 00000658-198007000-00014.