I-α-ketoglutaric (328-50-7) (71686-01-6) - Ifektri yomkhiqizi

α-ketoglutaric

ICofftek inamandla okukhiqiza ngobuningi kanye nokuhlinzekwa ngeCalcium 2-oxoglutarate ne-Alpha-Ketoglutaric Acid ngaphansi kwesimo se-cGMP.

Yini i-Alpha-Ketoglutaric Acid (328-50-7)?

I-Alpha-ketoglutaric acid iyinhlanganisela yebhayoloji etholakala ngokwemvelo emzimbeni womuntu. Futhi etholakala njengesengezo sokudla, i-alpha-ketoglutaric acid idlala indima enkulu kumjikelezo weKrebs (uchungechunge lokuphendula kwamakhemikhali okusetshenziselwa ukukhipha amandla agciniwe). Izithako ze-alpha-ketoglutaric acid kuthiwa zinikela ngezinzuzo ezahlukahlukene zezempilo, kufaka phakathi ukusebenza kwezemidlalo okuthuthukisiwe kanye nokwenza ngcono umzimba.

Izinzuzo ze-Alpha-Ketoglutaric Acid (328-50-7)

Uma kushiwo lokho, izifundo ezimbalwa zokuqala ziveze izinzuzo ezingaba khona ze-alpha-ketoglutaric acid supplementation. Nakhu okushiwo olunye ucwaningo lwamanje:
①Isifo Sezinso Esingapheli
I-Alpha-ketoglutaric acid isetshenzisiwe kusukela ngasekupheleni kweminyaka yama-1990s ukusiza ukwehla nokumunca amaprotheni kubantu abakwi-hemodialysis abadinga ukudla okunamaprotheni amancane. Ubufakazi bamuva buveza ukuthi kungaphinde kubambezele isidingo se-dialysis kubantu abanezifo zezinso ezingapheli (CKD). Ngokuya kocwaningo lwango-2017 kumagazini i-PLoS One, abacwaningi bathole futhi balandela abantu abayi-1,483 abane-CKD esezingeni eliphezulu abasebenzisa i-alpha-ketoglutaric acid supplement ebizwa ngeKetosteril. Isikhathi esilinganiselwe sokulandelwa kwakuyiminyaka eyi-1.57. Uma kuqhathaniswa nesethi ehambisanayo yabantu abangazange bathathe isengezo, labo abakwenzile babencane amathuba okudinga i-dialysis yesikhathi eside. Izinzuzo zanikezwa kuphela kulabo abathatha amaphilisi angaphezu kwama-5.5 ngosuku, okukhombisa ukuthi imiphumela yayixhomeke kumthamo. Ngaphandle kokutholakele okuhle, akucaci ukuthi iyiphi i-alpha-ketoglutaric acid eyadlala uma iqhathaniswa nezinye izithako ezisebenzayo zesengezo. Ucwaningo olwengeziwe luyadingeka.

HealthImpilo Yamathumbu
I-alpha-ketoglutaric acid supplements kukholelwa ukuthi iyi-anticatabolic, okusho ukuthi yehlisa noma ivimbele noma i-catabolism (ukuwohloka kwezicubu). Ngokwencazelo, inqubo yokuhleleka ibhekene nenqubo ye-anabolic (lapho kwakhiwa khona izicubu). Ucwaningo lwango-2012 kwi-Italian Journal of Animal Science lubike ukuthi i-alpha-ketoglutaric acid ivimbele ukuwohloka kwamathumbu kumagundane elabhoratri ondle ukudla okungenamaprotheni izinsuku eziyi-14. Esikhundleni sokuthola ukulimala kwe-villi efana nomunwe wamathumbu — umphumela olindelekile — amagundane adlisa i-alpha-ketoglutaric acid abengenawo umonakalo obonakalayo uma kuqhathaniswa namagundane abengekho. Ngaphezu kwalokho, amagundane ahlinzekele ukuthi izithasiselo zikwazile ukugcina ukukhula okujwayelekile yize kunamaphutha amaprotheni ngokuphelele. Ukweqiwa okuphezulu kunikezwe imiphumela engcono kakhulu. Okutholakele kubonakala kusekela imiphumela ye-alpha-ketoglutaric acid's anticatabolic. Ngaphezu kokusebenza kwayo ezifweni ezingapheli zezinso, i-alpha-ketoglutaric acid ingasiza futhi abantu abane-toxemia yamathumbu kanye nokuphazamiseka kwe-malabsorption njengesifo se-celiac. Ucwaningo olwengeziwe luyadingeka.

Ukusebenza kwe-Athletic
Ngokuphambene nalokho, imiphumela ye-anticatabolic ye-alpha-ketoglutaric acid ibonakala isilela uma isetshenziselwa inhloso yokukhula kwemisipha nokusebenza kwezemidlalo. Ngokusho kocwaningo luka-2012 ku- Journal of the International Society of Sports Nutrition, i-alpha-ketoglutaric acid ayinamphumela obonakalayo kumandla emisipha noma ekusebenziseni ukubekezela emadodeni ayi-16 abhekene nomsebenzi wokuzivocavoca umzimba. Kulolu cwaningo, uhhafu wamadoda unikezwe ama-3,000-milligrams (mg) e-alpha-ketoglutaric acid, kuyilapho enye ingxenye yanikezwa i-placebo imizuzu engama-45 ngaphambi kokwenza imishini yokunyathelisa ibhentshi nemilenze yokunyathelisa imilenze. Ngesonto elilandelayo, izithasiselo zafakwa, kwathi isigamu ngasinye sathola esinye isidakamizwa. Ukusebenza kwezemidlalo kwakususelwa kumthamo womthamo ophelele (i-TLV) wokuzivocavoca okwenziwe ngokuhambisana nezilinganiso zenhliziyo zangaphambi nangemva kokuzivocavoca. Okukhonjiswa yilokhu okutholakele ukungabikho kwempendulo ekhulayo akuyona into efanayo nempendulo ye-anabolic, ikakhulukazi phakathi kwabadlali.

I-Alpha-Ketoglutaric Acid (328-50-7) isebenzisa?

Ekuhlinzweni kwenhliziyo, i-alpha-ketoglutaric acid kwesinye isikhathi ihanjiswa ngemithambo (emthanjeni) ukunciphisa ukulimala kwemisipha yenhliziyo ngenxa yokwehla kwegazi. Ukwenza kanjalo kungathuthukisa nokugeleza kwegazi liye ezinso ngemuva kokuhlinzwa. Ukusetshenziswa kwayo njengesengezo kuncane kakhulu. Abanye abasebenzi abakholelwa ukuthi i-alpha-ketoglutaric acid ingaphatha noma ivimbele izimo ezahlukahlukene zezempilo, kufaka phakathi:
  • Lolu ngwengwezi lwakheka
  • Isifo sezinso ezingapheli
  • I-hepatomegaly (isibindi esikhulisiwe)
  • I-toxemia yamathumbu
  • I-thrush yomlomo
  • Kwamathambo
  • I-tendinopathy
  • Izifo zemvubelo
Ngenxa yendima yayo ekukhipheni amandla agciniwe, i-alpha-ketoglutaric acid ivame ukumakethwa njengesengezo sokusebenza kwezemidlalo. Abanye abasekeli baze bagomela ukuthi imiphumela yokwengeza ye-antioxidant inganciphisa ukuguga. Njengoba kuhlala kwenzeka ngezithasiselo ezithi zelapha izimo eziningi ezingahlobene, ubufakazi obusekela lezi zimangalo buthakathaka. Ezinye, njengezindawo zokwengeza "zokuguga" (okuncike kakhulu ocwaningweni lwango-2014 olubandakanya izibungu zematode), umngcele ongenakwenzeka.

I-Alpha-Ketoglutaric Acid (328-50-7) isilinganiso

Izithako ze-alpha-ketoglutaric acid ziyatholakala kuma-tablet, capsule, naku-powder formulations futhi zingatholakala kalula ku-inthanethi noma ezitolo ezikhethekile ngezithako zokudla. Ayikho imihlahlandlela yendawo yonke yokusetshenziswa okufanele kwe-alpha-ketoglutaric acid. Izithasiselo zivame ukuthengiswa ngemithamo esukela kuma-milligram angama-300 (mg) kuye ku-1,000 mg athathwa kanye ngosuku noma ngaphandle kokudla. Imithamo efinyelela ku-3,000 mg isetshenzisiwe ezifundweni ezingenayo imiphumela emibi.

I-Alpha-Ketoglutaric Acid (328-50-7) imiphumela emibi engaba khona

I-Alpha-ketoglutaric acid ibhekwa njengephephile futhi ibekezeleleke kahle. Ucwaningo oluphenya ngemiphumela ye-alpha-ketoglutaric acid lubike izimpawu ezimbalwa ezingemnandi ngemuva kweminyaka emithathu yokusetshenziswa. Njengenhlanganisela eyenziwe ngama-amino acid angabalulekile, i-alpha-ketoglutaric acid ayiyona into ongadlula kuyo kalula. Noma ikuphi okweqile emzimbeni kuzokhishwa emchameni noma kwehlukaniswe kube ngamabhulokhi ayisisekelo e-amino acid ngezinye izinjongo. Ngalokho kusho, ukuphepha kwe-alpha-ketoglutaric acid kwabesifazane abakhulelwe, omama abahlengikazi, nezingane akukasungulwa. Lokhu kufaka phakathi izingane ezinenkinga yemetabolism engandile efana nokushoda kwe-alpha-ketoglutarate dehydrogenase (lapho amazinga e-alpha-ketoglutaric acid ephakanyiswe ngokungajwayelekile).

I-Alpha-Ketoglutaric Acid powder iyathengiswa (Ungayitholaphi i-Alpha-Ketoglutaric Acid powder ngobuningi)

Inkampani yethu ijabulela ubudlelwano besikhathi eside namakhasimende ethu ngoba sigxila ekusebenzeni kwamakhasimende nasekuhlinzekeni ngemikhiqizo emihle. Uma unentshisekelo kumkhiqizo wethu, siyakwazi ukuguquguquka ngokwenza ngokwezifiso ama-oda avumelane nesidingo sakho esithile nesikhathi sethu sokuhola esisheshayo kuma-oda aqinisekisa ukuthi uzojabulela kakhulu umkhiqizo wethu ngesikhathi. Siphinde sigxile kuzinsizakalo ezengeza inani. Siyatholakala ngemibuzo yesevisi nolwazi ukusekela ibhizinisi lakho. Singumhlinzeki we-Alpha-Ketoglutaric Acid powder oqeqeshiwe iminyaka eminingana, sinikezela ngemikhiqizo ngamanani aphansi, futhi umkhiqizo wethu ungowekhwalithi ephezulu kakhulu futhi uhlolwa ngokuqinile, nokuzimela ukuqinisekisa ukuthi kuphephile ukusetshenziswa emhlabeni wonke.

Izikhombo:

  1. U-Abrahams JP, uLeslie AG, uLutter R, uWalker JE. Ukwakheka ku-2.8 Ukulungiswa kwe-F1-ATPase kusuka enhliziyweni yezinkomo i-mitochondria. Imvelo. 1994; 370: 621-628. i-doi: 10.1038 / 370621a0.
  2. Ama-Alpers DH. I-Glutamine: ingabe idatha iyayisekela imbangela yokwengezwa kwe-glutamine kubantu? I-Gastroenterology. 2006; 130: S106-S116. i-doi: 10.1053 / j.gastro.2005.11.049.
  3. U-Ashkanazi J, uCarpertier Y, uMichelsen C. Imisipha nama-plasma amino acid kulandela ukulimala. U-Ann Surg. 1980; 192: 78-85. i-doi: 10.1097 / 00000658-198007000-00014.