I-α-ketoglutaric (328-50-7) (71686-01-6) - Ifektri yomkhiqizi

i-α-ketoglutaric

ICofftek inamandla okukhiqiza ngobuningi kanye nokuhlinzekwa ngeCalcium 2-oxoglutarate ne-Alpha-Ketoglutaric Acid ngaphansi kwesimo se-cGMP.

Isibhengezo seCofttek

Thenga i-α-ketoglutaric powder

Yini i-Alpha-Ketoglutaric Acid (328-50-7)?

I-Alpha-ketoglutaric acid iyinhlanganisela yebhayoloji etholakala ngokwemvelo emzimbeni womuntu. Futhi etholakala njengesengezo sokudla, i-alpha-ketoglutaric acid idlala indima enkulu kumjikelezo weKrebs (uchungechunge lokuphendula kwamakhemikhali okusetshenziselwa ukukhipha amandla agciniwe). Izithako ze-alpha-ketoglutaric acid kuthiwa zinikela ngezinzuzo ezahlukahlukene zezempilo, kufaka phakathi ukusebenza kwezemidlalo okuthuthukisiwe kanye nokwenza ngcono umzimba.

Izinzuzo ze-Alpha-Ketoglutaric Acid (328-50-7)

Uma kushiwo lokho, izifundo ezimbalwa zokuqala ziveze izinzuzo ezingaba khona ze-alpha-ketoglutaric acid supplementation. Nakhu okushiwo olunye ucwaningo lwamanje:
①Isifo Sezinso Esingapheli
I-Alpha-ketoglutaric acid isetshenziswe kusukela ngasekupheleni kweminyaka yawo-1990 ukusiza ukudiliza nokumunca amaprotheni kubantu abasebenzisa i-hemodialysis abadinga ukudla okunamaphrotheni aphansi. Ubufakazi bakamuva buphakamisa ukuthi kungase kubambezele isidingo se-dialysis kubantu abanesifo sezinso esisezingeni eliphezulu (CKD).

(1)↗

Umthombo Othembekile

I-PubMed Central

Isizindalwazi esihlonishwa kakhulu esivela ku-National Institutes of Health
Iya kumthombo

Ngokocwaningo lwango-2017 kujenali i-PLoS One, abacwaningi bakhombe futhi balandela abantu abayi-1,483 abane-CKD ethuthukisiwe abasebenzisa isithasiselo se-alpha-ketoglutaric acid esibizwa nge-Ketosteril. Isilinganiso sesikhathi sokulandelela sasiyiminyaka engu-1.57.
Uma kuqhathaniswa nesethi efanisiwe yabantu abangazange bathathe isithasiselo, labo abakwenzile babemancane amathuba okuthi badinge i-dialysis yesikhathi eside. Izinzuzo zelulelwe kuphela kulabo abathatha amaphilisi angaphezu kuka-5.5 ngosuku, okubonisa ukuthi imiphumela incike kumthamo.
Ngaphandle kwemiphumela emihle, akucaci ukuthi iyiphi indima edlalwe yi-alpha-ketoglutaric uma kuqhathaniswa nezinye izithako ezisebenzayo zesithasiselo. Kudingeka olunye ucwaningo.

HealthImpilo Yamathumbu
I-Alpha-ketoglutaric acid supplements ikholelwa ukuthi i-anticatabolic, okusho ukuthi inciphisa noma ivimbele noma i-catabolism (ukuwohloka kwezicubu). Ngokwencazelo, inqubo ye-catabolic iphambene nenqubo ye-anabolic (lapho izicubu zakhiwe khona).
Ucwaningo lwango-2012 ku-Italian Journal of Animal Science lubike ukuthi i-alpha-ketoglutaric acid ivimbele ukuwohloka kwamathumbu kumagundane elebhu adla ukudla okungenamaprotheni izinsuku eziyi-14. Kunokuba abhekane nomonakalo ku-villi enjengomunwe wamathumbu-umphumela olindelekile-amagundane adla i-alpha-ketoglutaric acid ayengenawo umonakalo obonakalayo uma kuqhathaniswa namagundane ayengekho.
Ngaphezu kwalokho, amagundane anikeze izithasiselo akwazi ukugcina ukukhula okuvamile naphezu kokuntuleka okuphelele kwamaprotheni. Imithamo ephezulu inikezwe imiphumela engcono kakhulu.
Okutholakele kubonakala kusekela imiphumela ye-alpha-ketoglutaric acid ye-anticatabolic. Ngokungeziwe ekusebenziseni kwayo isifo sezinso esingamahlalakhona, i-alpha-ketoglutaric acid ingase futhi isize abantu abane-toxemia yamathumbu kanye nokuphazamiseka kwe-malabsorption njengesifo se-celiac. Kudingeka olunye ucwaningo.

Ukusebenza kwe-Athletic
Ngokuphambene, imiphumela ye-anticatabolic ye-alpha-ketoglutaric acid ibonakala iwa kancane uma isetshenziselwa inhloso yokukhula kwemisipha nokusebenza kwezemidlalo.
Ngokocwaningo lwango-2012 kuJournal of the International Society of Sports Nutrition, i-alpha-ketoglutaric acid yayingenawo umthelela obonakalayo emandleni emisipha noma ekuzivivinyeni kokuzivocavoca emadodeni ayi-16 anikwe umsebenzi wokujima ukuqeqeshwa kokumelana.

(2)↗

Umthombo Othembekile

I-PubMed Central

Isizindalwazi esihlonishwa kakhulu esivela ku-National Institutes of Health
Iya kumthombo

Kulolu cwaningo, isigamu samadoda sanikezwa i-3,000-milligrams (mg) ye-alpha-ketoglutaric acid, kanti enye ingxenye yanikezwa i-placebo imizuzu engu-45 ngaphambi kokwenza i-bench press kanye nokuzivocavoca kwemilenze. Ngesonto elilandelayo, izithasiselo zashintshwa, ingxenye ngayinye ithola omunye umuthi.
Ukusebenza komsubathi bekusekelwe enanini lomthwalo wevolumu (i-TLV) yokuzivocavoca okwenziwe ngokuhambisana nezinga lenhliziyo langaphambi nangemuva kokuzivocavoca. Lokhu okutholakele kubonisa ukungabi khona kwempendulo ye-catabolic akuyona into efanayo nempendulo ye-anabolic, ikakhulukazi phakathi kwabasubathi.

I-Alpha-Ketoglutaric Acid (328-50-7) isebenzisa?

Ekuhlinzweni kwenhliziyo, i-alpha-ketoglutaric acid ngezinye izikhathi ihanjiswa nge-intravenously (emthanjeni) ukuze kuncishiswe umonakalo emisipha yenhliziyo ngenxa yokuncipha kokugeleza kwegazi. Ukwenza kanjalo kungase futhi kuthuthukise ukugeleza kwegazi ezinso ngemva kokuhlinzwa.
Ukusetshenziswa kwayo njengesithasiselo akuqinisekile kangako. Abanye odokotela bakholelwa ukuthi i-alpha-ketoglutaric acid ingaphatha noma ivimbele izimo zempilo ezahlukahlukene, okuhlanganisa:
  • Lolu ngwengwezi lwakheka
  • Isifo sezinso ezingapheli
  • I-hepatomegaly (isibindi esikhulisiwe)
  • I-toxemia yamathumbu
  • I-thrush yomlomo
  • Kwamathambo
  • I-tendinopathy
  • Izifo zemvubelo
Ngenxa yendima yayo ekukhipheni amandla agciniwe, i-alpha-ketoglutaric acid ivamise ukuthengiswa njengesithasiselo sokusebenza kwezemidlalo. Abanye abasekeli baze bagomele ngokuthi imiphumela ye-antioxidant ye-supplement inganciphisa ukuguga.

(3)↗

Umthombo Othembekile

I-PubMed Central

Isizindalwazi esihlonishwa kakhulu esivela ku-National Institutes of Health
Iya kumthombo

Njengoba kuvame ukuba njalo ngezithasiselo ezithi zelapha izimo eziningi ezingahlobene, ubufakazi obusekela lezi zimangalo abunamandla. Ezinye, njengezakhiwo zesithasiselo "zokuvimbela ukuguga" (okusekelwe ikakhulukazi ocwaningweni lwango-2014 olubandakanya izikelemu ze-nematode), umngcele kulokho okungenzeki.

I-Alpha-Ketoglutaric Acid (328-50-7) isilinganiso

Izithasiselo ze-alpha-ketoglutaric acid ziyatholakala kumathebulethi, i-capsule, kanye ne-powder formulations futhi zingatholakala kalula ku-inthanethi noma ezitolo ezisebenza ngokukhethekile ngezithako zokudla.
Ayikho imihlahlandlela yendawo yonke yokusetshenziswa okufanele kwama-alpha-ketoglutaric acid. Izithako ezijwayelekile zithengiswa ngemithamo esukela ku-300 milligrams (mg) ukuya ku-1,000 mg ethathwa kanye ngosuku ngokudla noma ngaphandle kokudla. Imithamo efika ku-3,000 mg isetshenziswe ezifundweni ezingenazo imiphumela emibi.

I-Alpha-Ketoglutaric Acid (328-50-7) imiphumela emibi engaba khona

I-Alpha-ketoglutaric acid ithathwa njengephephile futhi ibekezelelwa kahle. Ucwaningo oluphenya ngemiphumela ye-alpha-ketoglutaric acid lubike izimpawu ezimbalwa ezimbi ngemva kweminyaka emithathu yokusetshenziswa.
Njengenhlanganisela eyenziwe ngama-amino acid angabalulekile, i-alpha-ketoglutaric acid ayiyona into ongakwazi ukweqisa kuyo kalula. Noma ikuphi okweqile emzimbeni kuzokhishelwa umchamo noma kuphulwe ku-amino acid yokwakha eyisisekelo ngezinye izinjongo.

(4)↗

Umthombo Othembekile

I-PubMed Central

Isizindalwazi esihlonishwa kakhulu esivela ku-National Institutes of Health
Iya kumthombo

Ngalokho okushiwo, ukuphepha kwe-alpha-ketoglutaric acid kwabesifazane abakhulelwe, omama abahlengikazi, kanye nezingane akukasungulwa. Lokhu kuhlanganisa izingane ezinezinkinga zemetabolism ezingavamile ezifana nokushoda kwe-alpha-ketoglutarate dehydrogenase (lapho amazinga e-alpha-ketoglutaric acid ekhuphuka ngokungavamile).

I-Alpha-Ketoglutaric Acid powder iyathengiswa (Ungayitholaphi i-Alpha-Ketoglutaric Acid powder ngobuningi)

Inkampani yethu ithokozela ubudlelwane besikhathi eside namakhasimende ethu ngoba sigxile ekusebenzeni kwamakhasimende nokunikezela ngemikhiqizo emihle. Uma unentshisekelo ngomkhiqizo wethu, siyavumelana nezimo nge-oda eyenziwe ngokwezifiso ukuze ivumelane nesidingo sakho esithile nesikhathi sethu sokuhola esisheshayo kuma-oda siqinisekisa ukuthi uzowunambitha kakhulu umkhiqizo wethu ngesikhathi. Siphinde sigxile nezinsizakalo ezingezwe zenani. Sitholakala ngemibuzo yensiza nolwazi lokuxhasa ibhizinisi lakho.
Singabahlinzeki be-Alpha-Ketoglutaric Acid powder abaqeqeshiwe iminyaka eminingana, sihlinzeka ngemikhiqizo ngentengo encintisanayo, futhi umkhiqizo wethu usezingeni eliphezulu kakhulu futhi uhlolwa okuqinile, okuzimele ukuze siqinisekise ukuthi uphephile ukusetshenziswa emhlabeni jikelele.

Izikhombo:

  1. U-Abrahams JP, uLeslie AG, uLutter R, uWalker JE. Ukwakheka ku-2.8 Ukulungiswa kwe-F1-ATPase kusuka enhliziyweni yezinkomo i-mitochondria. Imvelo. 1994; 370: 621-628. i-doi: 10.1038 / 370621a0.
  2. Ama-Alpers DH. I-Glutamine: ingabe idatha iyayisekela imbangela yokwengezwa kwe-glutamine kubantu? I-Gastroenterology. 2006; 130: S106-S116. i-doi: 10.1053 / j.gastro.2005.11.049.
  3. U-Ashkanazi J, uCarpertier Y, uMichelsen C. Imisipha nama-plasma amino acid kulandela ukulimala. U-Ann Surg. 1980; 192: 78-85. i-doi: 10.1097 / 00000658-198007000-00014.