I-Palmitoylethanolamide (PEA) (544-31-0)

I-Palmitoylethanolamide (PEA) (544-31-0) ividiyo

I-Palmitoylethanolamide (PEA) Siziqu

Yini iPalmitoylethanolamide (544-31-0)?

I-Palmitoylethanolamide (PEA), i-endo native (eyenziwe ngomzimba) fatty acid amide, ivela njenge-ejenti entsha ekwelapheni izinhlungu nokuvuvukala. Njengomenzeli wasendulo futhi otholakala ekudleni okufana namaqanda nobisi, akukho miphumela emibi kakhulu noma ukusebenzisana kwezidakamizwa. I-PeA ikhombisile ukusebenza kahle kobuhlungu obungapheli bezizinhlobo eziningi ezihambisana nezimo eziningi ezibuhlungu, ikakhulukazi ngobuhlungu be-neuropathic (nerve), ubuhlungu bokuvuvukala nobuhlungu be-visceral njenge-endometriosis ne-cystitis ye-interstitial.

Izinzuzo zePalmitoylethanolamide (544-31-0)

Ekuqaleni, iyanciphisa, nge-peroxisome proliferator-activated receptor alpha (PPARcy), ukuqasha futhi kusebenze amaseli we-mast kumasayithi wokulimala kwe-nerve kanye nokukhishwa kwabalameleli be-pro-inflammatory kusuka kulawa maseli; okwesibili, kuvimbela ukusebenza kwe-micoglia kanye nokuqashwa kwamaseli we-mast entanjeni yomgogodla ngemuva kokulimala kwe-peripheral nerve, kanye nokulandela ukulimala komgogodla noma ukulimala komgogodla.

Izifundo eziningana zigxile ekusetshenzisweni kwe-PEA ngobuningi bezimo zobuhlungu ezingapheli. Isibonelo, ingaba nomphumela omuhle njengokufana nokwelashwa ekwelapheni izinhlungu ezisezingeni eliphansi emuva noma wawusetshenziswa wedwa ukuphathwa kobuhlungu obungapheli ezigulini ezigula kakhulu, lapho ukusetshenziswa kwama-analgesics kwendabuko kungaholela ebungozini obukhulu bemiphumela emibi. Imiphumela ekhuthazayo ikhonjisiwe ekwelashweni kwama-radiculopathies angahlinzeki ngenqubo eyenziwe nge-ultra-micronized ye-PEA kanye nokwelashwa okuhlanganiswa ne-alpha-lipoic acid ukunciphisa i-prostatitis engapheli / isifo sezinhlungu ezingama-pelvic.

I-Palmitoylethanolamide (544-31-0) I-Mechanism Of Action?

I-Palmitoylethanolamide (PEA) iyi-endo native fat acid acid amide, i-analog ye-endocannabinoid anandamide (AEA), okungowomndeni kaN-acylethanolamines (NAE). Ama-NAE akhishwa kumaseli ngokuphendula okushukumisayo okungenangqondo. Njengawo wonke ama-NAE, futhi i-PEA inomphumela wasendaweni, futhi amazinga ayo wezicubu alawulwa kakhulu ngokusebenzisa ibhalansi lokukhiqiza nomsebenzi wokuwohloka. Ama-amidase amabili we-intracellular amidases, abonakaliswe kumaseli okuvuvukala, abambe iqhaza ekonakalisweni kwe-lipid amide: fatty-acid amide hydrolase (FAAH) ne-N-acylethanolamine hydrolyzing acid amidase (NAAA).

I-Palmitoylethanolamide (544-31-0) Isicelo

I-Palmitoylethanolamide (PEA) ingeyamalungu omndeni we-endocannabinoid, iqembu lama-amide acid amides. I-PeA kuye kwafakazelwa ukuthi inomsebenzi we-analgesic futhi wokulwa nokuvuvukala futhi isetshenziswe ezifundweni eziningana ezilawulwayo ezigxile ekuphathweni kobuhlungu obungapheli phakathi kweziguli ezindala ezinezimo zomtholampilo ezihlukile ezingaphansi.

I-Palmitoylethanolamide (PEA) powder ukudayiswa(Ungawuthengaphi u-Palmitoylethanolamide (PEA) powder ngobuningi)

Inkampani yethu ithokozela ubudlelwane besikhathi eside namakhasimende ethu ngoba sigxile ekusebenzeni kwamakhasimende nokunikezela ngemikhiqizo emihle. Uma unentshisekelo ngomkhiqizo wethu, siyavumelana nezimo nge-oda eyenziwe ngokwezifiso ukuze ivumelane nesidingo sakho esithile nesikhathi sethu sokuhola esisheshayo kuma-oda siqinisekisa ukuthi uzowunambitha kakhulu umkhiqizo wethu ngesikhathi. Siphinde sigxile nezinsizakalo ezingezwe zenani. Sitholakala ngemibuzo yensiza nolwazi lokuxhasa ibhizinisi lakho.

Singabahlinzeki be-powder abaqeqeshiwe bePalmitoylethanolamide (PEA) iminyaka eminingana, sinikezela ngemikhiqizo ngentengo yokuncintisana, futhi umkhiqizo wethu ungowekhwalithi ephezulu kakhulu futhi uhlolwa ngokuqinile, nokuzimela ukuqinisekisa ukuthi kuphephile ukusetshenziswa emhlabeni wonke.

Okubhekwayo

• UHansen HS. I-Palmitoylethanolamide namanye ama-anandamide congeners. Indima ehlongozwayo ebuchosheni obugulayo. I-Exp Neurol. 2010; 224 (1): 48-55
• Petrosino S, Iuvone T, Di Marzo V. N-Palmitoyl-ethanolamine: i-biochemistry namathuba amasha okwelapha. I-Biochimie. 2010; 92 (6): 724-7
• UCerrato S, Brazis P, della Valle MF, Miolo A, Puigdemont A. Umphumela we-Palmitoylethanolamide ku-histamine eyenga i-histamine, i-PGD2 ne-TNFα ekhishwa kumaseli wesikhumba se-canine. Vet Immunol Immunopathol. 2010; 133 (1): 9–15
• I-Palmitoylethanolamide (i-PEA): Izinzuzo, Umthamo, Ukusetshenziswa, Isengezo