I-Citicoline Sodium (33818-15-4)

Kwangathi 8, 2021

ICofttek ingumkhiqizi wempuphu oyi-Citicoline Sodium (CDP Choline Sodium) eChina. Ifektri yethu inohlelo oluphelele lokuphathwa kokukhiqizwa (i-ISO9001 & ISO14001), enekhono lokukhiqiza lanyanga zonke elingu-220kg.

 


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 1kg / isikhwama, 25kg / Drum

I-Citicoline Sodium (CDP Choline Sodium)(33818-15-4) Siziqu

Igama: I-Citicoline Sodium (CDP Choline Sodium)
CAS: 33818-15-4
Ukuhlanzeka 98%
Ifomula Yamamolekhula: C14H25N4NaO11P2
Isisindo Yamamolekhula: 510.308 g / mol
I-Melt Point: > 240 ° C
Igama lamakhemikhali: I-Citicoline Sodium; I-Cdp-choline sodium
omqondofana: Sodium [[(2S,3R,4S,5S)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]2-(trimethylazaniumyl)ethyl phosphate
InChI Key: I-YWAFNFGRBBBSPD-KDVMHAGBSA-M
Ukuphila okungaphelele: Amahora angu-56
Umswakama: I-soluble e-DMSO, Amanzi (kancane)
Isimo Sokugcina: Okomile, okumnyama naku-0 - 4 C isikhathi esifushane (izinsuku kuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni).
Isicelo: I-Citicoline Sodium ingumenzeli we-neuroprotective kanye ne-supplementary diet
ukubukeka: Iphini elimhlophe eliqinile

 

I-Citicoline Sodium (33818-15-4) I-NMR Spectrum

ICiticoline Sodium (33818-15-4) I-NMR Spectrum

Uma udinga i-COA, i-MSDS, i-HNMR yeqoqwana ngalinye lomkhiqizo nolunye ulwazi, sicela uxhumane nathi umphathi wezentengiso.

 

Kuyini I-Citicoline Sodium (CDP Choline Sodium)(33818-15-4) ?

I-Citicoline Sodium (i-CDP-choline Sodium, i-cytidine 5'-diphosphocholine) powder iyisakhi somzimba esincibilikayo samanzi esisebenza njengesandulela sombili we-choline ne-cytidine ngaphakathi kobuchopho (okuthi kamuva kuguqulwe kube yi-uridine). Kubantu, iCiticoline Sodium iyisakhi somzimba esibalulekile njengoba indima yayo ekwehliseni ubungozi bokukhubazeka kwamathambo e-neural, isifo sesibindi esinamafutha, nezinye izifo kubhaliwe. I-CDP-choline Sodium ingelinye lama-phospholipid amathathu aqukethe i-choline angafakwa ngomlomo (amanye amabili ayi-alpha-GPC ne-phosphatidylcholine).

 

I-Citicoline Sodium (CDP Choline Sodium)(33818-15-4) izinzuzo

I-CDP-choline yenza kusebenze i-biosynthesis ye-phospholipids yesakhiwo kulwelwesi lwe-neuronal, inyusa imetabolism ye-cerebral futhi isebenze emazingeni ama-neurotransmitter ahlukahlukene. Ngakho-ke, kufakazelwe ukuthi i-CDP-choline inyusa amazinga e-noradrenaline ne-dopamine ku-CNS.

Lesi sengezo senziwa ekuvimbeleni noma ekwelapheni ukukhunjulwa kwememori okuhambisana nokuguga ngenxa yokuthi kokubili ama-molecule ayinikezelayo futhi angathuthukisa ukufunda. Nakuba kubonakala sengathi iphumelela kangcono kune-phosphatidylcholine (i-PC) kule ndima, ngokwengxenye ngenxa yokwanda kwe-PC ebuchosheni, amandla ayo afana nokufana ne-Alpha-GPC.

 

I-Citicoline Sodium (CDP Choline Sodium)(33818-15-4) kusebenzisa

I-CDP-choline inokunye ukusetshenziswa engakusebenzisa maqondana nokuqonda. Ijwayele ukusetshenziswa njengesithuthukisi sememori ebusheni, kepha yize ezinye izifundo zamagundane ziphakamisa ukuthi lokhu kungenzeka nge-CDP-choline yomlomo, azikho izifundo zabantu ebusheni ngalesi sikhathi ngesikhathi. Ucwaningo olulodwa luye lwabona ukwanda kokunakwa nge-CDP-choline yedosi ephansi (edinga ukuphindwaphindwa), futhi i-CDP-choline ingaba nezindima njengenhlanganisela elwa nomlutha ngokumelene ne-cocaine kanye (nobufakazi bokuqala bukhombisa) nokudla ..

 

I-Citicoline Sodium (CDP Choline Sodium)(33818-15-4) Isicelo

I-Citicoline Sodium (i-CDP Choline Sodium) powder iyi-ejenti ye-neuroprotective. Isebenza ngokukhulisa ukuxhumana kwamaselula, ukuvuselela ukuhlanganiswa kwe-SAMe, nokwandisa i-glucose metabolism. I-Citicoline Sodium (CDP Choline Sodium) powder iyi-nucleotide eyenzeka ngokwemvelo; maphakathi nendlela enkulu ye-lecitin biosynthesis. I-Neuroprotective. Isetshenziselwa ukwelashwa kwesifo sohlangothi neschem trauma. Ukukhiqizwa kwe-Neuroprotective. I-Citicholine ikhombisa imiphumela yokuvikela ku-cerebral ischemia, ukulimala okulimazayo kobuchopho, nokuphazamiseka kwememori. Muva nje kukhonjiswe ukusebenza ngempumelelo kokuwohloka komqondo lapho kunikezwa ngama-AchEIs (Acetylcholinesterase inhibitor). Iveza ukusebenza kwe-Neuroprotective, i-acnticonvulsant nomsebenzi wokuthambisa kumthamo we-150mg / kg kumagundane. Kuboniswe ukuvikelwa kokukhubazeka kwengqondo okwenziwe nge-aluminium kumagundane anciphisa izinga eliphakeme le-glutamate, i-oxidativestress kanye NO ukukhiqizwa ngokweqile ku-hippocampus.

 

I-Citicoline Sodium (CDP Choline Sodium)(33818-15-4) powder ukudayiswa

(Ungayitholaphi i-Citicoline Sodium (i-CDP Choline Sodium)(33818-15-4) powder ngobuningi)

Inkampani yethu ithokozela ubudlelwane besikhathi eside namakhasimende ethu ngoba sigxile ekusebenzeni kwamakhasimende nokunikezela ngemikhiqizo emihle. Uma unentshisekelo ngomkhiqizo wethu, siyavumelana nezimo nge-oda eyenziwe ngokwezifiso ukuze ivumelane nesidingo sakho esithile nesikhathi sethu sokuhola esisheshayo kuma-oda siqinisekisa ukuthi uzowunambitha kakhulu umkhiqizo wethu ngesikhathi. Siphinde sigxile nezinsizakalo ezingezwe zenani. Sitholakala ngemibuzo yensiza nolwazi lokuxhasa ibhizinisi lakho.

Singochwepheshe I-Citicoline Sodium (CDP Choline Sodium)(33818-15-4) umphakeli we-powder iminyaka eminingana, sihlinzeka ngemikhiqizo ngentengo yokuncintisana, futhi umkhiqizo wethu usezingeni eliphakeme kakhulu futhi wenza ukuhlolwa okuqinile, okuzimele ukuqinisekisa ukuthi kuphephile ukusetshenziswa emhlabeni jikelele.

 

Okubhekwayo

[1] UTyurenkov IN, Kurkin DV, Bakulin DA, Volotova EV, Chafeev MA. [Umsebenzi we-cerebroprotective of metformin, gosogliptin, citicoline and a novel GPR119 agonist in a cerebral ischemia under a liteko lokuhlolwa kwesifo sikashukela mellitus]. UZh Nevrol Psikhiatr Im SS Korsakova. 2017; 117 (12. Vyp. 2): 53-59. doi: 10.17116 / jnevro201711712253-59. IsiRussia. I-PubMed PMID: 29411746.

[2] Jiang JJ, Xie YM, Zhang Y, Zhang YK, Wang ZM, Han B. [Izici zokwelapha zemithi yomjovo weShuxuening ekwelashweni kocwaningo lwe-cerebral infarction research based on ukubhaliswa]. UZhongguo Zhong Yao Za Zhi. 2016 Dec; 41 (24): 4516-4520. doi: 10.4268 / cjcmm20162407. IsiShayina. I-PubMed PMID: 28936832.

[3] U-Liu Y, u-Wang J, u-Xu C, u-Chen Y, u-Yang J, uLiu D, uNu H, u-Jiang Y, u-Yang S, u-Ying H. wasebenza kahle we-enzyme-catalyzed CDP-choline. I-Appl Microbiol Biotechnol. 2017 Feb; 101 (4): 1409-1417. doi: 10.1007 / s00253-016-7874-0. Epub 2016 Oct 13. I-PubMed PMID: 27738720.

[4] UGiménez R, Raïch J, Aguilar J (Novemba 1991). "Izinguquko ku-brain striatum dopamine kanye ne-acetylcholine receptors ezibangelwa ukwelashwa okungapheli kwe-CDP-choline yamagundane aguga". IBritish Journal Yezemithi. 104 (3): 575-8. i-doi: 1111 / j.1476-5381.1991.tb12471.x. PMC1908237PMID1839138.

[5] UTardner, P. (2020-08-30). "Ukusetshenziswa kwe-citicoline ekwelapheni ukwehla kwengqondo nokukhubazeka kwengqondo: Ukuhlaziywa kwe-meta-analysis of pharmacological literature • I-International Journal of Environmental Science & Technology". Ijenali Yomhlaba Wonke Yesayensi Yezemvelo Nezobuchwepheshe. Ibuyiswe ngo-2020-08-31.