UNicotinamide Riboside Chloride (NR) (23111-00-4) Umkhiqizi - uCofttek

I-Nicotinamide Riboside Chloride (NR) (23111-00-4)

April 7, 2020

I-Nicotinamide riboside, eyaziwa nangokuthi i-NR kanye ne-SRT647, ifomu le-pyridine-nucleoside le-vithamini B3 elisebenza njengesilandulelo se-nicotinamide adenine dinucleotide noma i-NAD +. I-NR ivimba ukukhubazeka kwe-dorsal root ganglion neurons exonised sevivo futhi ivikela ekulahlekelweni kwezindlebe okubangelwa umsindo.

 


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 1kg / isikhwama, 25kg / Drum

 

I-Nicotinamide Riboside Chloride (NR) (23111-00-4) ividiyo

 

I-Nicotinamide Riboside Chloride (NR) Siziqu

Igama: I-Nicotinamide Riboside Chloride (NR)
CAS: 23111-00-4
Ukuhlanzeka 98%
Ifomula Yamamolekhula: C11H15ClN2O5
Isisindo Yamamolekhula: 290.7 g / mol
I-Melt Point: I-115-125 ℃
Igama lamakhemikhali: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
omqondofana: I-Nicotinamide riboside; SRT647; I-SRT-647; I-SRT 647; I-Nicotinamide Riboside Triflate, ingxube ka-α / β
InChI Key: I-YABIFCKURFRPPO-FSDYPCQHSA-N
Ukuphila okungaphelele: 2.7 amahora
Umswakama: I-soluble e-DMSO, Methanol, Amanzi
Isimo Sokugcina: 0 - 4 C isikhathi esifushane (izinsuku kuya emavikini), noma -20 C isikhathi eside (izinyanga)
Isicelo: I-Nicotinamide riboside kuthiwa iyindlela entsha ye-pyridine-nucleoside ye-Vitit B₃ esebenza njenge-preursor ye-nicotinamide adenine dinucleotide noma i-NAD +.
ukubukeka: KuMhlophe kuPhale Yellow powder

 

Yini iNicotinamide Riboside Chloride (NR) CAS 23111-00-4?

I-Nicotinamide riboside, eyaziwa nangokuthi i-NR kanye ne-SRT647, ifomu le-pyridine-nucleoside le-vithamini B3 elisebenza njengesilandulelo se-nicotinamide adenine dinucleotide noma i-NAD +. I-NR ivimba ukukhubazeka kwe-dorsal root ganglion neurons exgically seveivo futhi ivikela ekulahlekelweni kokuzwa okubangelwa umsindo kumagundane aphilayo. INicotinamide riboside ivimbela imisipha, i-neural ne-melanocyte stem cell senescence. Ukwanda kabusha kwemisipha emgundweni kuye kwabonwa ngemuva kokwelashwa nge-nicotinamide riboside, okuholela ekuqageleni ukuthi kungathuthukisa ukuvuselelwa kabusha kwezitho ezifana nesibindi, izinso nenhliziyo. I-Nicotinamide riboside ibuye yehlise i-glucose yegazi kanye nesibindi esinamafutha kuma-prediabetesic bese uthayipha amamodeli we-2 sikashukela ngenkathi kuvinjelwa ukukhula kwe-neuropathy yesifo sikashukela. Qaphela: I-Nicotinamide Riboside chloride ingxube ye-α / β.

 

 

Izinzuzo zeNicotinamide Riboside Chloride (NR) CAS 23111-00-4

AmaNicotinamide nucleoside angamakhambi e-nicotinamide adenine dinucleotide (NAD) futhi amelela umthombo we-Vitamin B3. Ucwaningo lwakamuva luveze ukuthi ukuthatha inani elikhulu le-nicotinamide nucleosides ngokwemvelo ekudleni kunganikeza izinzuzo ezintsha zezempilo. Isibonelo, ama-nicotinamide nucleoside afakwe umfutho ekwandiseni ukuqina kwe-NAD izicubu nokufaka umuzwa we-insulin kanye nokwenza umsebenzi we-sirtuin usebenze. Amandla ayo okukhulisa ukukhiqizwa kwe-NAD aphakamisa ukuthi i-nicotinamide nucleosides futhi ingathuthukisa impilo ye-mitochondrial, ivuse umsebenzi we-mitochondrial, futhi inikeze ukukhiqizwa kwe-mitochondria entsha. Olunye ucwaningo olusebenzisa i-nicotinamide nucleosides kwimodeli yesifo i-Alzheimer's luveze ukuthi le molekyuli litholakala ngendlela engqondo futhi linganikeza i-neuroprotection ngokwazisa ubuchopho be-NAD.

INicotinamide Riboside Chloride nayo inganciphisa isisindo: Ucwaningo lukhombisile ukuthi ngokwandisa amandla emetabolism, ungakunciphisa ngempumelelo ukudla okunamafutha aphezulu okubangelwa ukuzuza kwesisindo. Ukuze kuhlolwe inqubo ye-nicotinamide ribose ye-NR ekhuthaza ukwehla kwesisindo, abacwaningi balinganise umsebenzi we-mitochondrial wesibindi ohambisana nokudla kwe-caloric, umsebenzi, amakhalori, umjikelezo okhalweni, isilinganiso sokuphumula, ukwakheka komzimba, ukubekezelelana kwe-glucose, ukuzwela kwe-insulin nokuhlukahluka kwamakhemikhali nokwakheka komzimba amapharamitha. Le datha kanye nendlela entsha yokwehlisa isisindo nge-malabsorption, ukukhishwa kwezimpawu zomzimba zokulandelela. Abaphenyi babika ukuthi amagundane aphakela izithasiselo ze-nicotinamide nicotinamide ayesengozini enkulu yokwehlisa isisindo uma kuqhathaniswa namagundane angazange anezele i-nicotinamide

 

 

UNicotinamide Riboside Chloride (NR) CAS 23111-00-4 I-Mechanism Of Action?

Ama-nucleoside eNicotinamide Riboside Chloride (NR) angaphambi kwe-nicotinamide adenine dinucleotide (NAD) futhi amele umthombo wevithamini B3. Ucwaningo lwakamuva lukhombisile ukuthi ukuthatha inani elikhulu lama-nicotinamide nucleosides ngokwemvelo akhona ekudleni kunganikeza izinzuzo ezintsha zezempilo. Isibonelo, ama-nicotinamide nucleosides abandakanyekile ekwandiseni ukugxila kwezicubu ze-NAD nasekunciphiseni ukuzwela kwe-insulin kanye nokwenza ngcono umsebenzi we-sirtuin. Amandla ayo okukhulisa ukukhiqizwa kwe-NAD asikisela ukuthi i-nicotinamide nucleosides nayo ingathuthukisa impilo ye-mitochondrial, ivuselele ukusebenza kwe-mitochondrial, futhi ikhuthaze ukukhiqizwa kwe-mitochondria entsha. Ezinye izifundo ezisebenzisa i-nicotinamide nucleosides kumodeli yesifo i-Alzheimer's zikhombisile ukuthi i-molecule ayitholakali ebuchosheni futhi ingahlinzeka nge-neuroprotection ngokushukumisa ukuhlanganiswa kobuchopho be-NAD ..

 

 

UNicotinamide Riboside Chloride (NR) CAS 23111-00-4 Isicelo

Ucwaningo olwenziwe ngaphambili lukhombisile ukuthi ukungezwa kwe-nicotinamide ribose kungeke nje ukukhuphule amazinga we-NAD + ngokuphepha, kepha futhi kwandise ukusetshenziswa kwe-NAD + kubantu, okungenzekiyo ngomunye uvithamini B3.Studies kukhombisile ukuthi uma sekuvela i-nicotinamide ribose esitokisini, umzimba uguqula ngokushesha ube yi-NAD +. La ma-NAD + abese evusa inqubo yokuqaliswa kokukhiqizwa kwamandla kwe-mitochondria

I-Nicotinamide Riboside Chloride ingakhulisa ukusebenza kwe-mitochondrial, okukhonjiswa ukuthuthukisa ukubonakaliswa kwamaphrotheni wokuhambisa amakhethini we-mitochondrial, ukuthuthukisa amandla we-mitochondrial membrane, futhi kukhuphule izinga lokuphefumula kwe-oxidative kanye ne-intracellular ATP amazinga. Lokhu kungahle kuhambisane namazinga aphezulu wokuvuselelwa kabusha kwe-mitochondrial. Umsebenzi we-mitochondrial wehla njengoba sikhula, futhi lokhu kuyisibonakaliso sokuguga kwamaseli we-stem esithola. I-NR ingakhuthaza ukusebenza kwe-mitochondria futhi ivimbele i-senescence yamaseli we-stem.

 

I-Nicotinamide Riboside Chloride (NR) powder ukudayiswa(Ungayithenga kuphi i-Nicotinamide Riboside Chloride (NR) powder ngobuningi)

Inkampani yethu ithokozela ubudlelwane besikhathi eside namakhasimende ethu ngoba sigxile ekusebenzeni kwamakhasimende nokunikezela ngemikhiqizo emihle. Uma unentshisekelo ngomkhiqizo wethu, siyavumelana nezimo nge-oda eyenziwe ngokwezifiso ukuze ivumelane nesidingo sakho esithile nesikhathi sethu sokuhola esisheshayo kuma-oda siqinisekisa ukuthi uzowunambitha kakhulu umkhiqizo wethu ngesikhathi. Siphinde sigxile nezinsizakalo ezingezwe zenani. Sitholakala ngemibuzo yensiza nolwazi lokuxhasa ibhizinisi lakho.

 

Singumhlinzeki we-Nicotinamide Riboside Chloride (NR) we-powder iminyaka eminingi, sinikezela ngemikhiqizo ngentengo yokuncintisana, futhi umkhiqizo wethu usezingeni eliphezulu kakhulu futhi uhlolwa ngokuqinile, ngokuzimela ukuqinisekisa ukuthi kuphephile ukusetshenziswa emhlabeni wonke.

 

Okubhekwayo

  • I-Chi Y, i-Sauve AA. I-Nicotinamide riboside, isakhi somkhondo ekudleni, siyivithamini B3 elinemiphumela kumandla we-metabolism kanye ne-neuroprotection. UCrr Opin Clin Nutr Metab Ukunakekelwa. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Buyekeza. I-PubMed PMID: 24071780.
  • I-Bogan KL, i-Brenner C. Nicotinic acid, i-nicotinamide, ne-nicotinamide riboside: ukuhlolwa kwamangqamuzana amavithamini e-NAD + angaphambili ekudleni kwabantu. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Buyekeza. I-PubMed PMID: 18429699.
  • I-Ghanta S, i-Grossmann RE, i-Brenner C. Mitochondrial protein acetylation njenge-cell-intrinsic, driver of changesism of kwisitoreji samafutha: logic yamakhemikhali ne-metabolic yokuguqulwa kwe-acetyl-lysine. UCr Rev Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Buyekeza. I-PubMed PMID: 24050258; I-PubMed Central PMCID: PMC4113336.
  • Konke okudingeka Ukwazi NgeNicotinamide Riboside Chloride