I-NR powder (23111-00-4)

April 7, 2020

ICofttek ingumkhiqizi ongcono kakhulu we-Nicotinamide Riboside Chloride powder eChina. Ifektri yethu inohlelo oluphelele lokuphathwa kokukhiqiza (i-ISO9001 & ISO14001), enomthamo wokukhiqiza wanyanga zonke ongu-2100kg.

 


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 1kg / isikhwama, 25kg / Drum

 

Ividiyo ye-NR powder (23111-00-4)

 

I-Nicotinamide Riboside Chloride (NR) Siziqu

Igama: I-Nicotinamide Riboside Chloride (NR)
CAS: 23111-00-4
Ukuhlanzeka 98%
Ifomula Yamamolekhula: C11H15ClN2O5
Isisindo Yamamolekhula: 290.7 g / mol
I-Melt Point: I-115-125 ℃
Igama lamakhemikhali: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
omqondofana: I-Nicotinamide riboside; SRT647; I-SRT-647; I-SRT 647; I-Nicotinamide Riboside Triflate, ingxube ka-α / β
InChI Key: I-YABIFCKURFRPPO-FSDYPCQHSA-N
Ukuphila okungaphelele: 2.7 amahora
Umswakama: I-soluble e-DMSO, Methanol, Amanzi
Isimo Sokugcina: 0 - 4 C isikhathi esifushane (izinsuku kuya emavikini), noma -20 C isikhathi eside (izinyanga)
Isicelo: I-Nicotinamide riboside kuthiwa iyindlela entsha ye-pyridine-nucleoside ye-Vitit B₃ esebenza njenge-preursor ye-nicotinamide adenine dinucleotide noma i-NAD +.
ukubukeka: KuMhlophe kuPhale Yellow powder

 

I-Nicotinamide Riboside Chloride

Umzimba womuntu uyisakhiwo esiyinkimbinkimbi esakhiwe ngamaseli, izicubu nezinhlelo zezitho zomzimba. Ukusebenza okufanele kwamaseli nezicubu emzimbeni kulawulwa futhi kusizwe ngamakhemikhali ahlukahlukene, ama-enzyme nezakhi zomzimba. Ezinye zazo umzimba ungazenza, kanti ezinye kufanele zisetshenziswe. Ngakho-ke, lezi zakhi zomzimba zisesimweni sokudla nezithasiselo. Enye yalezi zinto ezingasiza ekwelapheni nasekulawuleni umzimba ibizwa nge-nicotinamide riboside chloride (NR). Kuyasiza ukukhulisa inani le-nicotinamide adenine dinucleotide (NAD +) emzimbeni.

 

Wenzani uNicotinamide Riboside Chloride?

INicotinamide Riboside Chloride, ebizwa nangokuthi i-NR, iyi-pyridine nucleoside kavithamini B3. Isebenza njengomanduleli we-nicotinamide adenine dinucleotide (NAD +). Itholakala njengempuphu emhlophe ephuzi emhlophe. Ingenye yezandulela ze-NAD + ezifundwe kahle kakhulu njengoba inezinzuzo eziningi zezempilo. 

I-NAD + ihlotshaniswe njengenye yezinto eziphambili ezisebenza kuzinqubo ezahlukahlukene ze-homeostasis emzimbeni. Kungasiza ekugcineni umzimba uphilile, kukhulise isikhathi sokuphila kwamaseli, kusize ekwenzeni imisebenzi ehlukahlukene yokwenziwa komzimba nokusiza ekwelapheni i-pathophysiologies ehlukahlukene emzimbeni. 

I-NR powder ibonise ukusebenza kahle njengokwelashwa okukhulayo ezifweni ezahlukene. Emithamo ephezulu, i-NR ingaphatha izimo ezifana nezifo zenhliziyo, izifo ze-neurodegenerative, izifo zemisipha, kanye nokuphazamiseka komzimba. I-NR ikhonjisiwe futhi ukuthi ibambezela ukuguga kwamaseli futhi yandise impilo yawo. Kutholakala emikhiqizweni yokudla efana nenhlanzi, izinkukhu, amaqanda, ubisi nokusanhlamvu. 

 

Wenzani uNicotinamide Riboside Chloride?

Ukuqonda okwenziwa yi-nicotinamide riboside chloride, kufanele siqale siqonde i-nicotinamide adenine dinucleotide noma i-NAD +. 

I-NAD + iyi-coenzyme ebalulekile emzimbeni womuntu. Isebenza ekwenzeni izindlela ezahlukahlukene zokuhleleka komzimba. Ukuba khona kwayo emzimbeni kuyadingeka ekwelapheni izinhlobo eziningi zezifo. Kuyasiza nokukhiqiza amandla obuchopho, amaseli omzimba, kanye nemisipha.

Inani le-NAD + elingatholakala emithonjeni yokudla lincane kakhulu. Lokhu akwenele ukuthi amaseli amaningi omzimba awasebenzise. Ngakho-ke ukuze uwukhiqize, umzimba uhamba ezindleleni ezahlukahlukene. Kukhona izindlela ezintathu ezinkulu lapho i-NAD + ingahlanganiswa khona. Indlela ye-De novo synthesis, indlela ye-Preiss Handler, kanye nendlela ye-Salvage.  

Umzila weSalvage uyinqubo evame kakhulu okwenziwa ngayo i-NAD + emzimbeni. Kule ndlela, i-NAD + ibhekana nokuphendula kwe-redox. Kubandakanya ukwehliswa ngama-elektroni amabili afanayo, lawo aguqulwa abe yifomu ebizwa ngokuthi i-nicotinamide adenine dinucleotide (NADH). Njengoba ukwengezwa kokudla kunganele esidingweni somzimba se-NAD +, indlela ye-salvage isebenzisa iphinde isebenzise i-NAD + esivele isikhona nezinhlobo zayo ezihlukile. 

 Esinye sezenzo eziyinhloko ezenziwa yi-NAD + ukusebenzisa ama-sirtuin, iqembu lama-enzyme ayi-7, uSirt1 kuye kuSirt7. La ma-enzyme anomsebenzi wokulawula ukuguga nokuphila isikhathi eside kwamaseli. Ama-Sirtuin asebenza ngezinqubo eziningi ze-metabolic, njengokukhishwa kwe-insulin, ukugqugquzela ama-lipids, kanye nokuphendula kwengcindezi. Ingalawula ngisho nesikhathi sempilo. Ama-Sirtuin ayasebenza lapho amazinga e-NAD + enyuka. 

I-NAD + futhi iyi-substrate yeqembu lamaprotheni abizwa nge-poly ADP-ribose polymerase (PARP). Inesibopho sokulungiswa kwe-DNA nokuzinza kuma-genomes futhi kungenzeka ukuthi ibhekele isikhathi eside sokuphila. 

Amazinga we-NAD + ancipha ngobudala nokugula. Ezinye zezizathu zokwehla kwayo ukuvuvukala okungapheli, ukukhuphula ukusebenza kwamasosha omzimba, kanye nokwehla komsebenzi we-nicotinamide phosphoribosyltransferase (NAMPT), okuholela ekukhiqizweni kwawo okunciphile. Njengoba umzimba womuntu uguga, izinga lokulimala kwe-DNA lenyuka ngamathuba amancane okulungiswa, kubangele ukuguga nomdlavuza. 

Kunezindlela ezimbalwa zokwandisa amazinga wamazinga we-NAD + emzimbeni. Badla kancane futhi balawula inani lama-calories, ukuzila ukudla, nokuzivocavoca umzimba. Le misebenzi ingasiza futhi ukugcina umzimba uphilile futhi usebenza.

Amanye amasu okwandisa i-NAD + afaka phakathi ukusebenzisa i-tryptophan ne-niacin nokuthatha ama-NAD + boosters afana ne-nicotinamide riboside chloride ne-nicotinamide mononucleotide. 

INicotinamide riboside chloride iyisandulela esingakhuphula amazinga eselula eNAD +. Futhi kungumthombo weVitamin B3. Kungumkhiqizo osebenza endleleni ye-salvage yokukhiqizwa kwe-NAD +. Ishintsha ibe yi-nicotinamide mononucleotide (NMN) ngosizo lwe-enzyme NR kinase Nrk1. Ngemuva kwalokho iphinda iguquke ibe yi-NAD +. 

Ngemuva kokunikeza i-NR, amazinga e-NAD + akhula emzimbeni, bese usatshalaliswa ezingxenyeni ezahlukahlukene. Ayikwazi ukweqa umgoqo wobuchopho begazi, kepha iguqulwa ibe yi-nicotinamide bese ithuthelwa ebuchosheni nakwezinye izicubu lapho yakha khona i-NAD +. 

Ulwazi oluningi mayelana nokusebenza kweNicotinamide Riboside chloride luvela ocwaningweni lwezilwane. Ucwaningo olwenziwe ngabantu lusanqunyelwe futhi luyadingeka kakhulu.

 

Izinzuzo zeNicotinamide Riboside Chloride

Kunemihlomulo eminingana yokusebenzisa i-Nicotinamide Riboside Chloride. Kunjalo: 

 

Umphumela Wezifo Ze-Neuromuscular

Amandla kaNicotinamide riboside chloride okwandisa i-NAD + angathuthukisa imisebenzi ye-mitochondria. Lokhu kungasiza ekwelapheni i-mitochondrial myopathies [1]. I-NR powder nayo ikhonjisiwe ukuthi iyasebenza ekuthuthukiseni imisebenzi yama-dystrophies emisipha.

 

Imiphumela ezifweni zenhliziyo

Noma yiziphi izinkinga nge-NAD + metabolism zingadala izinkinga ngenhliziyo nangemithambo yegazi. Kungadala izimo ezinjengokwehluleka kwenhliziyo, ukucindezelwa ngokweqile, i-myocardial infarction, njll. I-NR supplementation ingaletha isilinganiso se-NAD + ne-nicotinamide adenine dinucleotide + hydrogen (I-NADH) ejwayelekile futhi imise ukulungiswa okungathandeki kwezicubu zenhliziyo [2]. Kungaguqula futhi imiphumela yokuhluleka kwenhliziyo. 

 

Imiphumela ezifweni ze-neurodegenerative

Izifo ze-Neurodegenerative zivame ukwenzeka ngokuguga. Zihlotshaniswa nengcindezi ye-oxidative engadala ukulimala ku-DNA. Imvamisa, kuzoba nezenzo ezingajwayelekile ze-mitochondria, okulandela ezinye izici lapho amaseli engeke akwazi ukusebenza kahle. I-NAD + incipha ngenani njengoba umzimba uguga, okuholela ekusebenzeni okungafanele kwe-mitochondria. Lokhu kungadala izifo ezahlukahlukene ze-neurodegenerative. Kungakhuphula namathuba wesifo i-Alzheimer's. 

INicotinamide Riboside chloride inyusa inani le-NAD + emzimbeni, inciphisa ukucindezeleka okwenziwe nge-oxidative, futhi ingalungisa ne-DNA elimele. Kuyasiza futhi ekwelapheni isifo i-Alzheimer's kumagundane [3]. Kunganciphisa nokuvuvukala ebuchosheni, kusize ukuthuthukisa ukuqonda nokukhumbula [4]. Lokhu kungakwenza ngokunciphisa inani le-amyloid-β precursor protein nokuvimbela i-amyloidogenesis. 

I-NR powder ingabuye imise ukuwohloka kwama-axon ezinhlobo ezingapheli zezifo ze-neurodegenerative ngokuguqula imetabolism ye-NR ku-axon [5]. Ukwehla kwama-ganglion neurons avunguza okungagcini amaseli ezinwele ezi-cochlear kungenzeka ngemuva kokuchayeka emisindweni eyeqile. I-NR ikhombisile ukuthi iyasebenza ekuvimbeleni ukulahleka kokuzwa okubangelwa umsindo. Lokhu ikwenza ngokusebenza kwi-sirtuin noma indlela encike ku-SIRT3 eyehlisa ukonakala kwe-neurite [6].  

 

Umphumela kwabanesifo sikashukela

INicotinamide ribonucleoside chloride ikhombisile ukuthi iyasebenza ekwehliseni izimpawu zokuphazamiseka kwemetabolism njengohlobo lwesifo sikashukela sohlobo II [7]. Kukhonjisiwe ukuthi kuthuthukisa ukubekezelelana kwe-glucose, kwehlise isisindo futhi kulaphe ukulimala kwesibindi kumagundane. Ngakho-ke kungasebenza ekwelapheni abantu futhi. 

 

Umphumela empilweni yesibindi

Izimo zesibindi ezinjengesifo sesibindi esinamafutha angenalo utshwala zibonisiwe ukuthi zibangela ukuntuleka kwe-NAD +. Ngakho-ke, ukwengeza nge-NR powder kungasiza ekululameni okungcono kulezi zimo [8]. 

 

Umphumela Ekugugeni 

I-NAD + nayo itholakale ukuthi inciphisa ukuguga kwamaseli nokuwavuselela. Kutholakale futhi ukuthi kuthuthukiswa imisebenzi ye-stem cell nayo esiza ukunciphisa ukuguga [9]. 

 

Usizo lweNicotinamide Riboside Chloride Ngaphezulu Kwamanye ama-NAD + Precursors

I-NR inokutholakala okungcono kwe-bioavailability futhi iphephe ukusetshenziswa uma iqhathaniswa nezinye izandulela. Kukhonjisiwe ukukhulisa amazinga we-NAD + ngaphezulu ekudleni ngomlomo kumagundane futhi kunikeze ne-NAD + eminingi emisipha uma kuqhathaniswa nezinye ezandulelayo. Ingalawula futhi amazinga e-lipid egazi kangcono futhi inyuse izinga le-NAD + enhliziyweni [10]. 

 

Imiphumela emibi yeNicotinamide Riboside Chloride

Ukudla ngomlomo kwe-nicotinamide riboside chloride ngamanani aphansi kuphephe kakhulu. Kungafaka eminye imiphumela emibi efana ne-

  • I-nausea
  • Ukuvimbela 
  • Edema
  • Itching
  • Ukukhathala
  • Ukuphathwa yikhanda
  • Uhudo
  • Isihlungu esiswini
  • Ukuzithoba
  • Ukuvota

 

Ungayithenga Kanjani iNicotinamide Riboside Chloride?

Uma ufuna ukuthenga i-NR powder, kungcono ukuxhumana ngqo nefektri yabakhiqizi beNicotinamide Riboside Chloride. Kuqinisekisa ukuthi kusetshenziswa izinto ezinhle kakhulu ekukhiqizeni, ngaphansi kweso elibukhali lochwepheshe emkhakheni ohlobene. Le mikhiqizo yenziwa ngokulandela imihlahlandlela eqinile yokuphepha eqinisekisa ukuthi umkhiqizo usezingeni eliphakeme, ngamandla amakhulu, futhi uhlanganiswe kahle. Ngokuya ngesidingo somsebenzisi, ama-oda angenziwa ngezifiso ukuze ahambisane nokunambitheka kwawo okuthile. 

Uma umkhiqizo wenziwe, udinga ukugcinwa ezingeni lokushisa elibandayo lika-0 kuye ku-4C isikhathi esifushane no -20C esikhathini eside. Ukuyivimbela ukuthi ingonakali noma isabele ngamanye amakhemikhali asemvelweni.

 

Okubhekwayo

  • I-Chi Y, i-Sauve AA. I-Nicotinamide riboside, isakhi somkhondo ekudleni, siyivithamini B3 elinemiphumela kumandla we-metabolism kanye ne-neuroprotection. UCrr Opin Clin Nutr Metab Ukunakekelwa. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Buyekeza. I-PubMed PMID: 24071780.
  • I-Bogan KL, i-Brenner C. Nicotinic acid, i-nicotinamide, ne-nicotinamide riboside: ukuhlolwa kwamangqamuzana amavithamini e-NAD + angaphambili ekudleni kwabantu. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Buyekeza. I-PubMed PMID: 18429699.
  • I-Ghanta S, i-Grossmann RE, i-Brenner C. Mitochondrial protein acetylation njenge-cell-intrinsic, driver of changesism of kwisitoreji samafutha: logic yamakhemikhali ne-metabolic yokuguqulwa kwe-acetyl-lysine. UCr Rev Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Buyekeza. I-PubMed PMID: 24050258; I-PubMed Central PMCID: PMC4113336.
  • Konke okudingeka Ukwazi NgeNicotinamide Riboside Chloride