I-Adelmidrol (1675-66-7) Umkhiqizi - Cofttek

I-Adelmidrol (1675-66-7)

June 29, 2022

I-Cofttek ingumkhiqizi we-Adelmidrol (1675-66-7) ongcono kakhulu e-China. Imboni yethu inohlelo oluphelele lokuphatha ukukhiqiza (ISO9001 & ISO14001), olunamandla okukhiqiza anyanga zonke angama-260kg.


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 1kg / isikhwama, 25kg / Drum

I-Adelmidrol Siziqu

Igama: I-Adelmidrol
CAS: 1675-66-7
Ukuhlanzeka 98%
Ifomula Yamamolekhula: C13H26N2O4
Isisindo Yamamolekhula: I-274.36 g / mol
Indawo yokuphuza: I-132-134 ºC
Igama lamakhemikhali: N,N′-Bis(2-hydroxyethyl)nonanediamide
omqondofana: I-Adelmidrol 1675-66-7 N,N'-bis(2-hydroxyethyl)nonanediamide AdelMitrol UNII-1BUC3685QU Okwengeziwe…
InChI Key: PAHZPHDAJQIETD-UHFFFAOYSA-N
Ukuphila okungaphelele: N / A
Umswakama: Incibilika emanzini; I-Ethanol; I-DMSO
Isimo Sokugcina: 0 - 4 C isikhathi esifushane (izinsuku kuya emavikini), noma -20 C isikhathi eside (izinyanga)
Isicelo: Isetshenziswa kakhulu e-Italy emithini yezilwane ukwelapha ukuvuvukala kwesikhumba. Ngo-2015, kwatholakala ukuthi i-compound nayo inesenzo sokulwa nokuvuvukala esinikezwe ngokuhlelekile ku-10 mg ngekhilogremu yesisindo somzimba.
ukubukeka: powder emhlophe

 

Iyini i-Adelmidrol (1675-66-7)?

I-Adelmidrol iyi-semisynthetic diethanolamide ephuma ku-azelaic acid, futhi inokwakheka kwamakhemikhali okulinganayo. Ihlelwe njenge-amide, futhi ifana ne-palmitoylethanolamide, i-molecule yomzali ekilasini lezidakamizwa ze-ALIAmide. I-ALIAmides yiqembu lokuphuma kwe-fatty acid enezakhiwo ze-cannabimimetic ezinemiphumela eqeda ukuvuvukala ne-analgesic futhi kucatshangwa ukuthi zenza ngokunciphisa ukusebenza kwe-mast cell. I-Adelmidrol iyi-anti-inflammatory ethanolamide ephuma ku-azelaic acid.

 

I-Adelmidrol (1675-66-7) izinzuzo

I-Adelmidrol iwukwenziwa kwe-azelaic acid, i-dicarboxylic acid egcwele ngokwemvelo, etholakala kwezinye izinhlamvu eziphelele futhi ngamanani amancane emzimbeni womuntu. Ngokwekhemikhali, i-ademidrol iyi-N,N-bis (2-hydroxyethyl) engeyona i-anediamide futhi iyinhlanganisela ye-amphiphilic noma i-amphipathic, enezinto zombili ze-hydrophilic kanye ne-hydrophobic, ethanda ukunyibilika kwayo kokubili emithonjeni yamanzi ne-organic. I-Adelmidrol ingeyomndeni we-aliamide, iqembu lokuphuma kwe-fatty acid enezakhiwo ze-cannabimimetic, ekwazi ukulawula i-mast cell (MC) hyperreactivity ezimeni eziningana ze-pathophysiological and pathological. Indlela ye-NF-κB ye-Pro-inflammatory yancishiswa ngokuphawulekayo ngokwelashwa nge-adelmidrol. Umphumela wokulwa nokuvuvukala we-adelmidrol ubonakale uhlobene nokuvula i-PPAR-gamma. I-Adelmidrol iphumelela ngokwezihloko ezinkingeni zesikhumba somuntu ezivuvukalayo futhi iyakwazi ukulungisa impendulo yokuvuvukala kuma-keratinocyte abantu. Inhlanganisela ye-hyaluronic acid ne-adelmidrol ithuthukisa izimpawu ze-osteoarthritis ezibangelwa i-monosodium iodoacetate.

 

I-Adelmidrol (1675-66-7) Isicelo?

I-Adelmidrol iyi-semisynthetic derivative ye-azelaic acid kanye ne-analogue ye-anti-inflammatory compound palmitoylethanolamide (PEA), i-aliamide nelungu lomndeni wama-fatty acid amide signaling molecules anezakhiwo ze-cannabimimetic. Imiphumela elwa nokuvuvukala kanye ne-antinociceptive ye-aliamide ye-PEA ne-adelmidrol iye yaboniswa ezifundweni eziningi zangaphambi komtholampilo, kokubili ku-vitro kanye ne-vivo. Izenzo zabo kucatshangwa ukuthi zibangelwa, okungenani ngokwengxenye, ikhono labo lokunciphisa ukusebenza kwe-mast cell kanye nokukhululwa komlamuleli we-mast cell ezimeni ze-pathophysiological kanye ne-pathological.

 

I-Adelmidrol powder ukudayiswa(Ungayithenga kuphi i-Adelmidrol powder ngobuningi)

Inkampani yethu ithokozela ubudlelwane besikhathi eside namakhasimende ethu ngoba sigxile ekusebenzeni kwamakhasimende nokunikezela ngemikhiqizo emihle. Uma unentshisekelo ngomkhiqizo wethu, siyavumelana nezimo nge-oda eyenziwe ngokwezifiso ukuze ivumelane nesidingo sakho esithile nesikhathi sethu sokuhola esisheshayo kuma-oda siqinisekisa ukuthi uzowunambitha kakhulu umkhiqizo wethu ngesikhathi. Siphinde sigxile nezinsizakalo ezingezwe zenani. Sitholakala ngemibuzo yensiza nolwazi lokuxhasa ibhizinisi lakho.

Singabahlinzeki bempushana be-Adelmidrol iminyaka eminingana, sihlinzeka ngemikhiqizo ngentengo encintisanayo, futhi umkhiqizo wethu ungowekhwalithi ephezulu kakhulu futhi uhlolwa okuqinile, okuzimele ukuze siqinisekise ukuthi iphephile ukusetshenziswa emhlabeni wonke.

 

Okubhekwayo

  1. Cerrato, Santiago; Brazis, Pilar; della Valle, Maria Federica; Miolo, Alda; Puigdemont, Anna (2012). "Umphumela ovimbelayo we-topical Adelmidrol ku-antigen-induced skin wheal kanye nokuziphatha kwe-mast cell kumodeli ye-canine ye-allergic dermatitis". I-BMC Veterinary Research. 8 (1): 230. doi:10.1186/1746-6148-8-230. I-PMC 3540011. PMID 23181761.
  2. Cordaro, M; Impellizzeri, D; Gugliandolo, E; USiracusa, R; Crupi, R; Esposito, E; Cuzzocrea, S (2016). "I-Adelmidrol, i-Palmitoylethanolamide Analogue, njenge-New Pharmacological Treatment for the Management of Inflammatory Bowel Disease". I-Molecular Pharmacology. 90 (5): 549–561. doi:10.1124/mol.116.105668. PMID 27625036.
  3. Abramo, F; Salluzzi, D; Leotta, R; I-Auxilia, S; Noli, C; Miolo, A; Isithwalambiza, P; Lloyd, D. H (2008). "I-Mast cell morphometry kanye ne-densitometry kumanxeba esikhumba okuhlola aphathwe ngejeli equkethe i-adelmidrol: Ucwaningo olulawulwa yi-placebo". Amanxeba : Inhlanganisela Yocwaningo Lwezempilo Nokuzijwayeza. 20 (6): 149–57. PMID 25942520.

 


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