I-Oleoylethanolamide (OEA) (111-58-0)

I-Oleoylethanolamide (OEA) (111-58-0) ividiyo

I-Oleoylethanolamide (OEA) Siziqu

Yini i-Oleoylethanolamide (OEA) CAS 111-58-0?

I-Oleoylethanolamine (OEA) iyi-ethanolamide lipid yemvelo eyenzeka ngokwemvelo kanye ne-receptor peroxisome proliferator-activated receptor-α (PPAR-α) agonist. Ikhiqizwa emathunjini amancane futhi ivimbela ukungena kokudla nge-activation ye-PPAR-α. I-OEA ibuye isebenze i-GPR119, i-lipid equkethe umzimba enomphumela we-hypophagic kanye nokulwa nokukhuluphala.

Oleoylethanolamide (OEA) CAS 111-58-0 izinzuzo

I-Oleoylethanolamide (OEA) iyi-metabolite yemvelo eyenziwe ngamanani amancane amathumbu akho amancane. I-OEA isiza ukulawula indlala, isisindo, amafutha omzimba ne-cholesterol ngokubopha kwi-receptor eyaziwa nge-PPAR-Alpha (Peroxisome proliferator-activated receptor alpha). Ngamafuphi, i-OEA ikhulisa ukwakheka kwamafutha omzimba futhi itshela ubuchopho bakho ukuthi ugcwele futhi sekuyisikhathi sokuyeka ukudla. I-OEA yaziwa nangokuthi inyusa ukusetshenziswa kwemali okuhlobene nokuzivocavoca okuhlobene nokuzivocavoca.

I-Oleoylethanolamide (OEA) CAS 111-58-0 I-Mechanism Of Action?

I-Oleoylethanolamide (i-OEA) yenziwe futhi yahlanganiswa emathunjini amancane asondelene avela ku-oleic acid etholakala ekudleni, njengamafutha omnqumo. Ukudla okunamafutha aphezulu kungavimbela ukukhiqizwa kwe-OEA emathunjini. I-OEA inciphisa ukudla ngokuvula i-homeostatic oxytocin kanye ne-histamine brain circry kanye ne-hedonic dopamine pathways. Kunobufakazi bokuthi i-OEA nayo inganciphisa ukusayinwa kwe-hedonic cannabinoid receptor 1 (CB1R), ukusebenza kwayo kuhlotshaniswa nokwanda kokudla. I-OEA inciphisa ukuthuthwa kwe-lipid kuma-adipocyte ukwehlisa isisindo samafutha. Ukuchazwa okuqhubekayo kwemiphumela ye-OEA ekudleni kokudla kanye ne-lipid metabolism kuzosiza ekutholeni izindlela zomzimba ezingabhekiswa ekuthuthukiseni izindlela zokwelapha zokukhuluphala ezisebenza kahle kakhulu.

I-Oleoylethanolamide (OEA) iyi-agonist ye-peroxisome proliferator-activated receptor-α (PPAR- α). I-N- Oleoylethanolamide ikhiqiza isignali yamathumbu evuselela umsebenzi ophakathi we-dopamine osungula ukuxhumana phakathi kwabalawuli be-caloric- homeostatic kanye ne-hedonic- homeostatic. I-Oleoylethanolamide ifakiwe njengenqubo yamangqamuzana ehambisana nempumelelo yokudlula esiswini. I-N- Oleoylethanolamide iyi-agonist ye-GPR55 ekhethiwe.

I-Oleoylethanolamide (OEA) CAS 111-58-0 Isicelo

I-Oleoylethanolamide (i-OEA) isebenza ukwenza okuthile okubizwa nge-PPAR futhi ngasikhathi sinye kukhuphula ukushiswa kwamafutha futhi kunciphise ukugcinwa kwamafutha. Uma udla, amazinga e-OEA ayakhula futhi nesifiso sakho sokwehla lapho izinzwa zezinzwa ezixhumanisa nobuchopho bakho zikutshela ukuthi usuthi. I-PPAR-α yiqembu le-ligand-activated nuclear receptor ebandakanyeka ekuvezweni kofuzo lwe-lipid metabolism kanye ne-energyhomeostasis pathways.

I-Oleoylethanolamide (OEA) powder ukudayiswa(Ungayithenga kuphi i-Oleoylethanolamide (OEA) powder ngobuningi)

Inkampani yethu ithokozela ubudlelwane besikhathi eside namakhasimende ethu ngoba sigxile ekusebenzeni kwamakhasimende nokunikezela ngemikhiqizo emihle. Uma unentshisekelo ngomkhiqizo wethu, siyavumelana nezimo nge-oda eyenziwe ngokwezifiso ukuze ivumelane nesidingo sakho esithile nesikhathi sethu sokuhola esisheshayo kuma-oda siqinisekisa ukuthi uzowunambitha kakhulu umkhiqizo wethu ngesikhathi. Siphinde sigxile nezinsizakalo ezingezwe zenani. Sitholakala ngemibuzo yensiza nolwazi lokuxhasa ibhizinisi lakho.

Singumhlinzeki we-powder oqeqeshiwe we-Oleoylethanolamide (OEA) iminyaka eminingana, sinikezela ngemikhiqizo ngentengo yokuncintisana, futhi umkhiqizo wethu ungowekhwalithi ephezulu kakhulu futhi uhlolwa ngokuqinile, nokuzimela ukuqinisekisa ukuthi kuphephile ukusetshenziswa emhlabeni jikelele.

Okubhekwayo

1. UGaetani S, Oveisi F, uPiomelli D (2003). "Ukushintshwa kwephethini yokudla esilinganisweni ngumlamuli we-anorexic lipid oleoylethanolamine". I-Neuropsychopharmacology. 28 (7): 1311-6. i-doi: 10.1038 / sj.npp.1300166. I-PMID 12700681.
2. ULo Verme J, uGaetani S, uFu J, u-Oveisi F, uBurton K, uPiomelli D (2005). "Umthethonqubo wokudla okudliwayo yi-oleoylethanolamine". Iseli. UMol. Impilo Sci. 62 (6): 708-16. i-doi: 10.1007 / s00018-004-4494-0. I-PMID 15770421.
3. UGaetani S, Kaye WH, uCuomo V, uPiomelli D (Septhemba 2008). "Indima ye-endocannabinoids kanye ne-analogue yazo ekukhuluphaleni nasekudleni kokudla". Yidla Ukungezwani Kwesisindo. 13 (3): e42-8. I-PMID 19011363.