Ngokuya kwabantu bazi ngokwengeziwe izinzuzo ze I-Oleoylethanolamide (OEA), isidingo se-Oleoylethanolamide (I-OEAIzengezo zikhuphuke kakhulu emakethe. Lokhu kuholele ekutheni izinkampani ezikhiqizayo zibangisane ukukhiqiza izithasiselo ezisezingeni eliphakeme ezizobamba iqhaza emakethe. Uma ungumkhiqizi wezithako zezempilo ohlela ukungena emakethe yezengezo ye-Oleoylethanolamide (OEA), kufanele uqinisekise ukuthi uthola i-Oleoylethanolamide (OEA) powder esezingeni eliphakeme. Ukuhlwaya izinto ezisezingeni elihle kuyisinyathelo sokuqala ekuqinisekiseni impumelelo yanoma yiliphi ibhizinisi. ICofttek ingumhlinzeki oqeqeshiwe we-Oleoylethanolamide (OEA) okuthengisela kuphela imikhiqizo esebenza kahle kakhulu kule makethe iminyaka engaphezu kwengu-10.

Yini i-Oleoylethanolamide (OEA)?

I-Oleoylethanolamide yakhiwe ngamagama amathathu: i-oleoyl, i-ethanol ne-amide. Ukuze kube lula kithi, sikubhekisa ku-OEA ngamafuphi. Kuyaziwa nangokuthi i-oleothanolamine.
I-ethanolamide lipid yemvelo esebenza njengomlawuli maqondana nenqubo yokudla nesisindo somzimba kuzo zonke izinhlobo zama-vertebrate. Kuyi-metabolite ye-oleic acid eyakhiwa emathunjini amancane omzimba womuntu. Inamathele ku-PPAR Alpha receptor esiza ukulawula izinto ezine: indlala, amafutha omzimba, i-cholesterol, nesisindo. I-PPAR Alpha isho i-Peroxism Proliferator-activated Receptor Alpha.

Ukusebenza kwe-Oleoylethanolamide (oea)

I-OEA noma i-Oleoylethanolamide yisidakamizwa esikusiza ukulawula isisindo, imikhuba yokudla, ne-cholesterol. Kuyinto yemetabolite yemvelo. Ilawula amanoni omzimba wakho ngokwandisa imetabolism yamafutha akhona emzimbeni wakho. Isebenza ngendlela ethakazelisa kakhulu.

Njengoba futhi udla ukudla, lo muthi uzothumela isignali ebuchosheni bakho ukukucela ukuthi uyeke ukudla noma uthathe okunye ukudla njengoba umzimba wakho usuthathe ukudla okwanele futhi awusadingi okunye. Ngaleyo ndlela, uzoqala ukuzwa ukuthi usuthi futhi ngalokho uyeka ukudla. Ngakho-ke, kancane kancane uqhubeka uthatha inani elincane lokudla isikhathi ngasinye njalo. Ngakho-ke, ngokuhamba kwesikhathi, ungakwazi ukunciphisa isisindo ngezinga elikhulu.

Oleoylethanolamide
Oleoylethanolamide

Ukusetshenziswa kwe-Oleoylethanolamide (OEA)

Ukusetshenziswa kwe-OEA kusebenze ngendlela ehleleke kakhulu. Okokuqala, kwandisa igebe ngesikhathi phakathi kwesidlo esisodwa kuya ekudleni okulandelayo. Okwesibili, kuyasiza ekwehliseni ukuguquguquka kwemisipha. Okwesithathu, ilawulwa izakhi ezitholakalayo.

Imiphumela yokusebenza kwe-OEA nezici zayo zokuhlomula zatholakala eminyakeni engamashumi amahlanu edlule. Kwakungekho lolo cwaningo olunzulu futhi oluhlelekile mayelana ne-OEA ngaphambi konyaka we-2001. Kwakungabaphenyi baseSpain abaqala ukufunda nge-OEA, bahlolwa kumagundane ukuthola imiphumela. Ucwaningo luthi i-OEA ayinamphumela omubi ebuchosheni kodwa ingashintsha imikhuba yokudla futhi ibe nomthelela ekuziphatheni kwendlala.
Ifomula yefomula ithi C2OH39NO2. Inombolo eyingqayizivele ye-CAS ngu-111-58-0. I-OEA iyinhlanganisela ye-oleic acid ne-ethanolamine. Lapho kukhona amafutha acebile akhona engxenyeni engenhla yamathumbu amancane emzimbeni wethu yindawo lapho kwenziwa khona lezi zingxenye ezimbili. I-OEA ifana kakhulu futhi iyafana ne-endocannabinoid anandamide kepha kungcono kakhulu.

Izinzuzo ze-Oleoylethanolamide (OEA)

I-OEA iyisidakamizwa sosizo sangempela esitholakala emakethe. Okulandelayo okunye okuphawuleka kakhulu izinzuzo ze-OEA.

Oleoylethanolamide

Yehlisa izinga le-ghrelin

IGhrelin yihomoni etholakala emzimbeni wethu evusa inkanuko yethu. Kutholakale ukuthi i-OEA isiza ukunciphisa leli zinga le-hormone emzimbeni wethu uma le OEA iphathwa.

Yehlisa amafutha emzimbeni ngezinga elikhulayo

Lo mjovo utholakala usebenza ngempumelelo ekwehliseni amanoni omzimba nokuthi nawo ngezinga elikhulayo. Kwandisa imiphumela ye-metabolism ye-mitochondria. Kuze kunciphise nokudla ngendlela ephumelelayo futhi kukhuphule nezinga lamandla omzimba wakhoUPi-Sunyer FX, u-Aronne LJ, uHeshmati HM, uDevin J, uRosenstock J…

③ Igcina izinga le-peptide yy liphansi

I-Peptide YY iyi-hormone evuselela isifiso sethu sokudla. Imijovo ye-OEA uma ithathiwe izosiza ekwehliseni nasekugcineni izinga le-Peptide YY hormone liphansi impela.

Oleoylethanolamide

④ Isiza ukulawula isifiso sokudla

Ukuthatha umjovo we-OEA kuzosiza ukulawula isifiso sokudla ngokunciphisa isikhala samafutha emzimbeni wethu. Kuqinisa nokushiswa kwamafutha anqwabelene emizimbeni yethu. Njengoba futhi udla nini, i-OEA iqala ukusebenza. Iphakamisa izinga lokusebenza kwayo futhi ngasikhathi sinye inciphisa izinga lakho lokudla ngokuthumela amasiginali ebuchosheni futhi yazise ukuthi waneliseke ngokweqile futhi awudingi okunye ukudla ongakudla.

Oleoylethanolamide

⑤ Ayikho imiphumela emibi

Ngemuva kokubuyekeza i-OEA, kufakazelwe ukuthi akekho noyedwa owake wabhekana nemiphumela emibi ngemuva kokuyifaka emzimbeni. I-OEA iyi-oleic acid ethathwa njengengxenye yokudla kwakho okunempilo nokunomsoco.

Effects Imiphumela emihle ekukhathazekeni

I-OEA ithinta kahle ukukhathazeka. Ukufakwa kwe-OEA kusiza ukugcina ingqondo yakho ikhululekile ekukhathazekeni futhi ngaleyo ndlela kusize ekugcineni izifo zezifo zokukhathazeka zikhona.

⑦ Yandisa i-hdl emzimbeni

Kunezinhlobo ezimbili ze-cholesterol ekhona emzimbeni wethu. Ziyi- LDL Cholesterol ne-HDL Cholesterol. I-LDL iyi-cholesterol embi kanti i-HDL iyi-cholesterol enhle. Ukudla kwe-OEA kusiza ukunciphisa i-LDL Cholesterol futhi kwandise i-HDL Cholesterol.

Ids Izinsiza zokwakha umzimba

Ukwakha umzimba wakho ukwakheka okufanele nokwakheka futhi ngokulingana kungenye yezimfashini zakamuva emhlabeni wanamuhla. Ikakhulukazi embonini yemfashini noma yokuzijabulisa emzimbeni womzimba ifunwa kakhulu. Ukudla kwe-OEA nakho kuyasiza ekwakheni umzimba njengoba kwehlisa amanoni emzimbeni wakho.

Umthamo we-oleoylethanolamide (oea)

Isilinganiso se-OEA kungathathwa ngezindlela ezimbili ngokuya ngeseluleko sikadokotela:

I-OEA ithathe ngaphandle kokunye okunye ukwesekwa kokunciphisa isisindo

Uma i-OEA capsule ithathwa ngaphandle kwesengezo sokunciphisa isisindo ungathatha i-1 OEA capsule ka-200mg.

I-OEA ithathe nenye ibhekwa yokunciphisa isisindo

Uma i-OEA capsule ithathwa kanye nesinye isithasiselo sokunciphisa isisindo ungathatha i-1 OEA capsule ka-100 mg kuye ku-150 mg.

Umuntu kufanele adle i-OEA capsule imizuzu engamashumi amathathu ngaphambi kokudla. Lokhu kuzokugcina usutha ngokwengeziwe ngenkathi udla futhi ngaleyo ndlela uzogcina udla inani elincane lokudla.

Ngaphezu kwalokho, ungakhuphula noma wehlise izinga lomthamo wakho wansuku zonke we-OEA ngokuya ngesisindo somzimba wakho. Ake sithi, umuntu onesisindo esingu-150 lb uthatha i-OEA capsule ka-100mg. Kodwa uma umuntu enesisindo sama-250 lb, angathatha i-OEA capsule ka-180 mg.

Umphakeli wento eluhlaza we-Oleoylethanolamide (OEA)

Umuntu angathenga isidakamizwa se-OEA esitolo sezidakamizwa esaziwayo futhi esinekhono esiseduze nendawo ohlala kuyo noma angasithenga ngoku-oda online. Kepha umuntu kufanele aqaphele kakhulu kulokhu ngoba bonke abahlinzeki balo muthi kungenzeka bangabi yiqiniso.

Ngakho-ke, hlola njalo idumela kanye nekhono le- izitolo zezidakamizwa online futhi ngalokho, kuhlale kunconywa ukuthi ubheke imininingwane yezibuyekezo zabathengi abanolwazi. Qiniseka ngokufakwa komkhiqizo njengokuthi uvaliwe kahle noma cha ukugwema noma yiluphi uhlobo lokungcola okungaholela ezindabeni ezithile eziyingozi ngaphambili kwezempilo.

I-Oleoylethanolamide (oea) ngesimo se-powder

I-OEA isesimweni sayo sokuqala ayitholakali ngendlela yamaphilisi noma amaphilisi. Noma kunjalo, ungakwazi thenga i-OEA powder ngobuningiemakethe uma kudingeka. Leli fomu lempuphu lifakwe kokuqediwe umkhiqizo ngokuyenza ibe ngu-15% OEA noma u-50% we-OEA oleic acid. Ipulani yeCima OEA igcinwa phakathi kwama-90% kuye kuma-95% ikakhulukazi phakathi kwabathengi baseYurophu nase-United States.

Thenga i-Oleoylethanolamide (OEA) powder ngobuningi

Ungafaka i-oda eliku-inthanethi lokuthengwa kwenqwaba yempuphu noma ungathenga ngisho nasezitolo zendawo ezidumile. Isitoreji silula esimweni se-OEA powder. Udinga ukuyibeka ekamelweni lokushisa. Kepha, akufanele ihlangane nomswakama noma imisebe yelanga eqondile. Ngakho-ke, udinga ukuyigcina ivaliwe ngokuqinile endaweni epholile futhi eyomile.

STABILITY

Ukusetshenziswa kwe-OEAcan kungakusiza ngezindlela eziningi! Ngalesi sizathu, kunconyelwa wonke umuntu njengoba kungenayo imiphumela emibi. Kungenza ngisho nendlela yokuphila enempilo emndenini wakho ukuthi inenze nonke nikhule futhi nikhanyise isimo, isitayela, nangokuhlonipha nokuzethemba. Ukugcina nokugcina umzimba wakho usesimweni, ikakhulukazi kulabo abakhuluphele kancane, ngeke nje kukwenze uzizwe ujabule kodwa futhi kuzokwenza nabanye bazizwe bejabule futhi beziqhenya ngawe.

I-OEA izokusiza nokuthi ukhiphe ukukhathazeka kwengqondo kukusize wakhe isithombe esihle ezingqondweni zabanye. Ngakho-ke, esikhundleni sokuzizwa uthukuthele futhi ungajabule, sekuyisikhathi esihle sokuthatha isenzo bese uqala ukusebenzisa i-OEA futhi uzomangala kakhulu ukubona amandla ayo omlingo futhi uzozizwa uphulukisiwe futhi ucindezelwe.

Isihloko ngu: UDkt. Zeng

Isihloko ngu:

UDkt Zeng

Co-founder, ubuholi benkampani obuyinhloko bokuphatha; I-PhD itholwe kuFudan University ku-organic chemistry. Isipiliyoni seminyaka engaphezu kwengu-10 ku-organic chemistry kanye nokwakhiwa kwezidakamizwa synthesis; Cishe amaphepha ocwaningo ayishumi ashicilelwe emaphephandabeni anegunya, anamalungelo obunikazi angaphezu kwamahlanu aseChina.

Okubhekwayo

(1).UPi-Sunyer FX, u-Aronne LJ, uHeshmati HM, uDevin J, uRosenstock J. Umphumela we-rimonabant, i-cannabinoid-1 receptor blocker, ngesisindo nangezinto ezinobungozi be-cardiometabolic ezigulini ezikhuluphele ngokweqile noma ezikhuluphele: I-RIO-North America: isilingo esilawulwa ngokungahleliwe. Ijenali yeAmerican Medical Association. 2006; 295 (7): 761-775.

(2).UGiuseppe Astarita; UBryan C. Rourke; UJohnnie B. Andersen; UJin Fu; UJanet H. Kim; U-Albert F. Bennett; UJames W. Hicks noDaniele Piomelli (2005-12-22). "Ukwanda kwe-postprandial kwe-oleoylethanolamine ukugqugquzela emathunjini amancane we-python yaseBurma (Python molurus)". NginguJ J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412.

USarro-Ramirez A, Sanchez-Lopez D, Tejeda-Padron A, Frias C, Zaldivar-Rae J, Murillo-Rodriguez E. Ama-molecule ebongo nesifiso: icala le-oleoylethanolamide. Ama-Agent Aphakathi Kwesistimu Yezinzwa Ezemithi Yezokwelapha. 3; 2013 (13): 1-88.

(4).Uhambo lokuhlola i-egt

(5).I-Anandamide vs cbd: yikuphi okungcono empilweni yakho? Konke odinga ukukwazi ngabo!

(6).Konke odinga ukukwazi mayelana ne-nicotinamide riboside chloride.

(7).Izithasiselo ze-Magnesium l-threonate: izinzuzo, isilinganiso, nemiphumela emibi.

(8).I-Palmitoylethanolamide (ipea): izinzuzo, isilinganiso, ukusetshenziswa, ukwengeza.

(9).Izinzuzo eziphezulu zezempilo eziyi-6 zezengezo ze-resveratrol.

(10).Izinzuzo ezi-5 eziphezulu zokuthatha i-phosphatidylserine (ps).

(11).Izinzuzo ezi-5 eziphezulu zokuthatha i-pyrroloquinoline quinone (pqq).

(12).Isengezo esihle kakhulu se-alpha gpc.

(13).Isengezo esihle kakhulu sokulwa nokuguga se-nicotinamide mononucleotide (nmn).