Kungani Sidinga iNicotinamide Riboside Chloride

Imboni yezimonyo imboni yamadola ayizigidi eziyizinkulungwane, ikakhulukazi ngoba abantu bayazifela ngendlela ababukeka ngayo. Lokhu futhi kuyisici esibalulekile sokuthi kungani ucwaningo oluzungeze izithako nemikhiqizo elwa nokuguga lwenze intuthuko enhle kangako ngesikhathi esifushane kangaka. Ama-conglomerate asemhlabeni wonke ayaqonda ukuthi kunemali enziwe ngesifiso sabantu sokuhlala bebasha kuze kube manje, ngakho-ke, babe namaqembu endaweni, banikele izinsuku namasonto ukuthola izithako nemikhiqizo engathuthukisa amandla esikhumba. INicotinamide Riboside noma i-Niagen yatholakala ngenxa yalokhu kusesha okunganqandeki kwemikhiqizo elwa nokuguga. Ngenkathi imikhiqizo eminingi elwa nokuguga inciphisa izimpawu zokuguga esikhunjeni, iNiagen inciphisa izimpawu zokuguga emzimbeni. I-Nicotinamide Riboside noma i-Niagen ifomu le-crystal le I-Nicotinamide Riboside Chloride futhi kanye ngaphakathi komzimba, iguquka ibe yi-NAD +, ebhekele ukuguga okunempilo neminye imisebenzi ebalulekile. 

Kulesi sihloko, sihlanganisa zonke izici zale nhlanganisela yezimanga, kufaka phakathi izinzuzo zayo, imiphumela emibi kanye nomthamo ofanele.

 

Yini iNicotinamide Riboside Chloride?

I-Nicotinamide Riboside Chloride noma i-Niagen ifomu lekristalu leNicotinamide Riboside, okuyi-NAD + precursor vitamin. Ngenkathi iNicotinamide Riboside inesisindo esingu-255.25 g / mol, iNicotinamide Riboside Chloride inesisindo esingu-290.70 g / mol no-100 mg weNicotinamide Riboside Chloride ihlinzeka ngama-88 mg eNicotinamide Riboside. I-NR ibhekwa njengephephile ukuthi isetshenziswe ekudleni.

Yize iNicotinamide Riboside iyindlela yeVitamin B3, izakhiwo zayo ezahlukahlukene zenza ihluke kakhulu kwamanye amalungu eqembu lamavithamini B3, anjenge-nicotinamide ne-niacin. Ngenkathi uNiacin ebangela ukuba isikhumba sishwabane ngokuvula i-GPR109A G-protein coupept receptor, iNicotinamide Riboside ayiphenduki nakancane ngaleli receptor futhi, ngakho-ke, akubangeli ngisho nokushwabana kwesikhumba, noma ngabe kudliwe ngamanani aphezulu we-2000 mg ngosuku. Ngaphezu kwalokho, ukuhlolwa okwenziwe kumagundane kuveze ukuthi iNicotinamide Riboside ingukuqala kwe-NAD + okuholele ekuthini kunesipikili esiphezulu eNicotinamide Adenine Dinucleotide noma i-NAD + emzimbeni. 

INicotinamide Riboside iyenzeka ngokwemvelo ekudleni komuntu futhi kanye ngaphakathi komzimba, iyashintsha ibe yi-NAD +, edingwa ngumzimba imisebenzi ehlukahlukene. Isibonelo, ucwaningo lwesayensi lufakazele ukuthi iNicotinamide Riboside Chloride noma i-NAD + enikezwe yi-NR ithuthukisa ukusebenza kwe-mitochondrial kanye nokuzwela kwe-insulin ngokwenza kusebenze umndeni we-sirtuin wama-enzyme, obhekene nokulawula umqubuko we-oxidative emzimbeni.

Kuze kube manje, kwenziwa izifundo ezinhlanu zokufunda ngokuphepha nokusebenza kahle kweNicotinamide Riboside futhi zonke lezi zifundo zithole ukuthi i-compatheni iphephile ukuthi isetshenziswe ngabantu.

 

I-Nicotinamide Riboside Chloride Izinzuzo

Ngaphambi kokuba sixoxe nge izinzuzo zeNicotinamide Riboside Chloride, kubalulekile ukucacisa ukuthi njengoba iNicotinamide Riboside Chloride ingusawoti okutholakele kuyo iNicotinamide Riboside, izinzuzo zeNicotinamide Riboside Chloride ziyefana nezinzuzo zeNicotinamide Riboside.

 

INicotinamide Riboside Chloride Ikhuthaza Ukuguga Okunempilo

I-NAD + eyenziwe yasebenza yiNicotinamide Riboside Chloride ngaphakathi komzimba isebenzisa ama-enzyme athile axhumene nokuguga okunempilo. Enye ye-enzyme enjalo yi-sirtuins, eye yaxhunyaniswa nokuphila okuthuthukile ngokuphelele kanye nokuphila ezilwaneni. Ucwaningo lwesayensi lufakazele ukuthi ama-sirtuins athuthukisa ikhwalithi yempilo nokuphila isikhathi eside ngokunciphisa ukuvuvukala, athuthukise izinzuzo ezihambisana nokuvinjelwa kwekhalori futhi alungise ne-DNA elimele. I-NAD + eyenziwe yasebenza yiNicotinamide Riboside Chloride futhi isebenzisa ama-polymerases ama-Poly ayaziwa ukulungisa iDNA eyonakele. Ngaphezu kwalokho, izifundo eziningana zesayensi zixhumanise umsebenzi wama-polymerases nesikhathi sokuphila esithuthukisiwe. 

 

Inciphisa Amathuba Omuntu Wokuthuthukisa Izifo Zenhliziyo

Ukuguga futhi kwandisa amathuba okuba nesifo senhliziyo. Njengoba abantu bekhula eminyakeni yobudala, imithambo yabo yegazi iyaqina futhi iqine, okuholela ekunyukeni kwengcindezi yegazi. Lapho umfutho wegazi ngaphakathi kwemithambo ukhula, inhliziyo kufanele isebenze kanzima ngokuphindwe kabili ukumpompa igazi, okuholela ezifweni zenhliziyo ezahlukahlukene. I-NAD + enikezwe yiNicotinamide Riboside Chloride iguqula izinguquko ezihlobene nobudala ezidalwe yimithambo yegazi. Kunobufakazi obuningi besayensi bokufakazela ukuthi iNicotinamide Adenine Dinucleotide noma i-NAD + ayinciphisi ukuqina kwesitsha segazi kuphela kepha ilawula nomfutho wegazi we-systolic.

 

INicotinamide Riboside Chloride Futhi Inikeza Ukuvikelwa Kwamaseli Brain

INicotinamide Riboside ivikela amangqamuzana obuchopho. Ucwaningo olwenziwe kumagundane luveze ukuthi ukukhiqizwa okwenziwe yi-NR kwe-NAD + kukhuphule ukukhiqizwa kwamaprotheni e-alpha ye-PGC-1 kufika kuma-50%. Iphrotheni ye-alpha ye-PGC-1 isiza ukuvikela amaseli obuchopho ekulweni nengcindezi ye-oxidative futhi ithuthukise nomsebenzi we-mitochondrial. Ngakho-ke, ukusetshenziswa kwe-NR kubantu kuvikela ezifweni zobuchopho ezibangelwa iminyaka, njenge-Alzheimer's neParkinson's. Olunye ucwaningo oluthile lwacwaninga ngomphumela wamazinga we-NAD + kubantu abaphethwe yi-Parkinson. Ucwaningo luphethe ngokuthi i-NAD + ithuthukise umsebenzi we-mitochondrial kumaseli we-stem.

 

Ezinye Izinzuzo Ezibalulekile zeNicotinamide Riboside Chloride

Ngaphandle kwezinzuzo ezixoxwe ngenhla, Nazi izinzuzo ezimbalwa ezingeziwe ezihlobene neNicotinamide Riboside Chloride.

  • I-NR yaziwa ukuqinisa amandla emisipha, ukusebenza nokukhuthazela ngakho-ke, ukusetshenziswa kwe-NR kuhlangene nokusebenza okungcono kwemidlalo.
  • Njengoba kushiwo ngenhla, ukukhiqizwa okwenziwe yi-NR kwe-NAD + kulungisa i-DNA elimele futhi kunikeza ukuvikelwa ekucindezelekeni kwe-oxidative. Lokhu-ke kwehlisa namathuba okuba nomdlavuza.
  • Ucwaningo luhlaziye umphumela weNicotinamide Riboside ku-metabolism kumagundane. Ucwaningo lwaphetha ngokuthi i-NR inyusa imetabolism kumagundane. Noma kudingeka ubufakazi obuningi besayensi maqondana nalokhu, ososayensi abaningi bakholelwa ukuthi iNicotinamide Riboside ingaba nomphumela ofanayo kubantu futhi ngenxa yalokho, kufanele ilusizo ngokuncipha kwesisindo.

I-Nicotinamide Riboside Chloride

Isidakamizwa seNicotinamide Riboside Chloride

Izifundo ezinhlanu ezenziwayo kuze kube manje sezithole ukuthi iNicotinamide Riboside iphephile ukusetshenziswa ngabantu. Kodwa-ke, lezi zifundo zisungule ephephile I-Nicotinamide Riboside Chloride isilinganiso Umkhawulo wabantu ngaphakathi kwe-1,000 2,000 kuye ku-XNUMX XNUMX mg ngosuku. Kodwa-ke, kufanele kukhunjulwe ukuthi zonke izifundo ezihlaziya ukuphepha kweNicotinamide Riboside zazinosayizi omncane wesampula futhi ngenxa yalokho, ucwaningo olwengeziwe luyadingeka kule ndawo. 

Inhloso yokuqala yeNicotinamide Riboside Chloride ukuhlinzekela i-Nicotinamide Riboside Chloride noma iNiagen emzimbeni. I-Niagen noma i-NR ivame ukutholakala ngezindlela ezimbili: amaphilisi namaphilisi. Abakhiqizi abaningi abengeziwe beNicotinamide Riboside bahlanganisa i-NR namanye amakhemikhali, anjengePterostilbene. Kunoma ikuphi, ukuze uphephe, abakhiqizi abaningi abengeziwe bancoma ukugcina ukubanjwa nsuku zonke kwe-NR phakathi kwama-250 kuye kwangama-300 mg ngosuku.

 

Ingabe iNicotinamide Riboside Chloride Iphephile?

Izifundo eziningana eziqhutshwe kuze kube manje zithole ukusetshenziswa kweNicotinamide Riboside ku-1000 kuya ku-2000 mg ngosuku kuphephile ukusetshenziswa kwabantu. Kodwa-ke, njengoba kudingeka izifundo ezengeziwe zikakhonkolo kule ndawo, abenzi beNicotinamide Riboside bancoma ukuthi umuntu adle i-NR nsuku zonke ngaphansi kuka-250-300 mg ngosuku.

Yize ukusetshenziswa kweNicotinamide Riboside noma kweNicotinamide Riboside Chloride kuphephile, kungaholela emiphumeleni emibi efana nesicanucanu, ikhanda elibuhlungu, ukuqunjelwa, ukukhathala nohudo. Uma uhlangabezana nenye yalezi zimpawu ngenkathi uthatha isengezo se-NR, thintana nodokotela wakho ngokushesha. Ngaphezu kwalokho, njengoba bungekho ubufakazi obanele mayelana nomphumela weNicotinamide Riboside kwabesifazane abakhulelwe nabancelisayo, leli qembu kufanele lihlukane nokusetshenziswa kwezithako zeNicotinamide Riboside. 

 

I-Nicotinamide Riboside Chloride Supplement

Uma ufuna imifino I-Nicotinamide Riboside Chloride ukwengeza, sincoma ukwengezwa kweTru Niagen Nicotinamide Riboside. Lesi sithasiselo sisebenzisa i-NIAGEN, umkhiqizo we-NR onelungelo lobunikazi lenkampani. Inkampani yokukhiqiza isebenza kuphela ngezithasiselo zeNicotinamide Riboside ngakho-ke, umuntu angaqiniseka ukuthi izithasiselo ezenziwe yinkampani zisezingeni eliphakeme kakhulu. Isengezo seTru Niagen Nicotinamide Riboside sifika ngama-capsule okulula ukuwadla, okulula ukuwaginya. Abasebenzisi kudingeka ukuthi bathathe i-capsule eyodwa kuphela ngosuku.

Kodwa-ke, uma ufuna i-gluten, iqanda, i-BPA, amantongomane, izinto zokuvikela kanye nomkhiqizo ongenalo ubisi, sincoma ukuthi ufake imali yakho ku-Thorne ResveraCel Nicotinamide Riboside supplement. Lesi sithasiselo sihlanganisa i-NR nama-flavonoids. Ngokubambisana, lezi ezimbili zithuthukisa umsebenzi we-sirtuin. Okubaluleke kakhulu, iThorne ResveraCel ithi yenza imijikelezo emine yokuhlola kwisengezo sayo ngasinye futhi ngenxa yalokho, izithako zenkampani ziphephe ngokuphelele. Ngaphezu kwalokho, lezi zithasiselo zikhiqizwa endaweni eqinisekisiwe ye-cGMP e-United States nasendaweni eqinisekisiwe ye-TGA e-Australia.

I-Nicotinamide Riboside Chloride

Ukuphi Ukuthenga I-Nicotinamide Riboside Chloride Powder ngobuningi?

Isidingo sokuncengelwa kweNicotinamide Riboside sikhuphuke kakhulu eminyakeni embalwa edlule, ikakhulukazi ngoba iNicotinamide Riboside inezinzuzo eziningi. Uma ufuna ukuphinda ungene emakethe yezithasiselo zeNicotinamide Riboside, into yokuqala okufanele uyenze ukuthola umhlinzeki wezinto ezingavuthiwe onokwethenjelwa nothembekile. Kuzo yiwaphi buy I-Nicotinamide Riboside Chloride ufulawa ngobuningi? Impendulo iwukuthi Cofttek.

ICofttek ngumphakeli wezinto zokusetshenziswa okhiqizwe ngonyaka ka-2008 futhi cishe ishumini leminyaka, inkampani isisungule ubukhona bayo emazweni amaningana. Ngaphandle kokukhiqiza imikhiqizo ethembekile, inkampani ibuye igxile ekwenzeni intuthuko emkhakheni we-biotechnology, ubuchwepheshe bamakhemikhali nokuhlolwa kwamakhemikhali. Inkampani futhi izimisele ocwaningweni oluseqophelweni, okuyinikeza umphetho ngaphezu kwabanye abahlinzeki emakethe. The I-Nicotinamide Riboside Chloride powder  enikezwe yinkampani iza ngama-25 kgs futhi ithembekile ngekhwalithi. Ngaphezu kwalokho, inkampani ine abathengisi abahle kakhulu nethimba lokusekelwa kwamakhasimende elizonakekela zonke izidingo zakho kanye nemibuzo ngesikhathi sangempela. Lokhu, uma ufuna ukuthenga i-Nicotinamide Riboside Chloride powder ngobuningi, trust kuphela uCofttek. 

 

Okubhekwayo
  1. IConze, D., Brenner, C. & Kruger, CL Ukuphepha kanye neMetabolism Yokuphathwa Kwesikhathi Eside kwe-NIAGEN (Nicotinamide Riboside Chloride) ku-Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adult. Sci Rep9, 9772 (2019)
  2. UCarlijn ME Remie, uKay HM Roumans, uMichiel PB Moonen, uNiels J Connell, uBas Haskes, uJulian Mevenkamp, ​​uLucas Lindeboom, uVera HW de Wit, u-Tineke van de Weijer, uSuzanne ABM Aarts, u-Esther Lutgens, u-Bauke V Schomaker, uHunung L Elfrink, URubén Zapata-Pérez, uRiekelt H Houtkooper, uJohan Auwerx, uJoris Hoeks, uVera B Schrauwen-Hinderling, u-Esther Phielix, uPatrick Schrauwen, uNicotinamide riboside supplementation alters compositionation body and skeletal misuli acetylcarnitine rejores in labantu abanempilo enempilo, I-American Journal of Clinical Nutrition, Umqhumo 112, Isikhalazo 2, Agasti 2020, amakhasi 413–426
  3. U-Elhassan, YS, Kluckova, K., Fletcher, RS, Schmidt, MS, Garten, A., Doig, CL, Cartwright, DM, Oakey, L., Burley, CV, Jenkinson, N., Wilson, M., uLucas , S., Akerman, Mina, Seabright, A., Lai, YC, Tennant, DA, Nightingale, P., Wallis, GA, Manolopoulos, KN, Brenner, C,… Lavery, GG (2019). I-Nicotinamide Riboside Augions the Aged Human Skeletal Muscle NAD + Metabolome ne-Induces Transcripttomic ne-Anti-inflammatory Signature. Imibiko yeselula28(7), 1717-1728.e6.
  4. I-Nicotinamide Riboside Chloride powder

 

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