UMBONO WAMAHHALA WOKUGCINA

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Ukujwayela umzimba ngokujwayelekile
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Ukungcoliswa komoya
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Imisebe ye-Ultraviolet
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Ukungcola kwensimbi eningi
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Ukungcoliswa kwezibulala-zinambuzane
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Ukungcoliswa kwezibulala-zinambuzane

 

 

IMISEBENZI YAMAHHALA NEZIFO

 

Imvamisa, ama-radicals amahhala ayadingeka emizimbeni, kepha ama-radicals wamahhala ngokweqile angadala ukungalingani kokusebenza komzimba, bese kuholela ekucindezelekeni kwe-oxidative okuvela ezifweni ezahlukahlukene (imibhalo ekhombisa ukuthi ama-radicals amahhala angumthombo wezifo ezahlukahlukene).

 

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I-ANTIOXIDANT

 

Imizimba yethu ayikwazi ukusebenza ngaphandle komoya-mpilo, futhi uma inani elikhulu lama-radicals amahhala lenyuka, umzimba ongaphansi kwengcindezi ye-oxidative uzokwenza ukuthi uhlelo lokulungisa lwehluleke ekususeni ama-radicals wamahhala ngokweqile. Ezimweni ezikhethekile, umzimba udinga ukugcwalisa ama-antioxidants in vitro ukususa ama-radicals wamahhala ngokweqile.

 

UKUTHUTHUKISWA KWAMA-ANTIOXIDANTS

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L-ERGOTHIONEINE -UHLOBO OLUSHA LWE-ANTioxidant Yemvelo

 

Umhl iyi-chiral yemvelo i-amino-acid antioxidant biosynthesized kumagciwane athile nesikhunta. Kuyinhlanganisela ebalulekile ye-bioactive esetshenziswe njenge-scavenger enamandla, isihlungi se-ultraviolet ray, umlawuli we-oxidation-reduction reaction kanye ne-bioenergetics yeselula, kanye ne-cytoprotector yomzimba, njll.
I-L-Ergothioneine (i-EGT, i-ERGO, i-CAS: 497-30-3), eyaziwa nangokuthi (S) -cy-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- Usawoti wangaphakathi we-4-ethanaminium, ekuqaleni wakhishwa ku-ergot nguTanret C ngonyaka ka-1909, wabe usutholakala egazini lesilwane. I-EGT emsulwa iyikristalu emhlophe, inyibilika emanzini, (ichithwe u-0.9mol / L endaweni yokushisa yasekamelweni). I-Autoxidation ayikwazi ukwenzeka ngenani le-pH yemvelo noma kusisombululo se-alkali esinamandla. I-EGT ingaba khona ngezindlela ezimbili ze-isomer - ifomu le-thiol nefomu le-thione, njengoba kukhonjisiwe ngezansi:

 

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ISIQINISEKISO

Ngezinzuzo zemisebenzi eminingi, Umhl ivelele phakathi kwamanye ama-antioxidants amaningi.

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UBUHLE

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Ngezinzuzo zemisebenzi eminingi, i-EGT ivelele phakathi kokunye okuningi AntioxidantsIzinzuzo (uma kuqhathaniswa ne-glutathione, cysteine ​​njll.):
——EGT kulula ukuyiqongelela kumaseli futhi ukuhlushwa kuzinzile ukwedlula amanye ama-antioxidants.
———EGT isebenza ngempumelelo ekunciphiseni ukufa kweseli okubangelwa i-pyrogallol.
——EGT ikakhulukazi ihlasela i-ROS ukuvimbela i-oxidation, kuyilapho i-glutathione nabanye bethwebula ama-radicals wamahhala, okusho ukuthi, okunye Antioxidants scavenge imikhiqizo ye-oxidation.(1) Oleoylethanolamide (oea) - induku yemilingo yempilo yakho

Ukuqhathaniswa KOKUFANYELELA

Ezenye: Umhl ibingumdwebi osebenza kakhulu wama-radicals wamahhala uma kuqhathaniswa nama-antioxidants akudala njenge-GSH, i-uric acid ne-trolox. Ikakhulu, umthamo ophakeme kakhulu we-antioxidant okhonjiswe yi-EGT vs. peroxyl radicals uholele ngama-25% aphezulu kunenani elitholwe ngereferensi antioxidant trolox. Umthamo wokukhwabanisa we-EGT maqondana ne-hydroxyl radicals wawungaphezulu ngama-60%, uma kuqhathaniswa ne-uric acid, emele ireferensi antioxidant vs. hydroxyl radicals. Ekugcineni, i-EGT ikhombise umsebenzi ophakeme kakhulu we-antioxidant futhi maqondana ne-peroxynitrite, enekhono lokukhwabanisa elingu-10% ngaphezulu kunele-uric acid.

 

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EMINYE IMISEBENZI

 

I-EGT inemiphumela kulawulo lwamandla we-intracellular,

kuthuthukisa ukungatheleleki,

ukwenza ngcono isilinganiso sokusinda kwesidoda,

ukuvikela isibindi ekulimaleni,

ukuvimbela ukuvuvukala,

i-neurodegeneration,

iziphazamiso zokuthuthuka nokukhubazeka.

 

 

UKUDINGEKA KWENTUTHUKO

① AMAHLA ATHOLWE NGOKUBANZI KWEZIMBALI NEZILWANE

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② IMIYALELO

I-5-10mg iyunithi ngayinye yomuntu omdala kanye nama-2-3 amayunithi wokudla okuqhubekayo kubalulekile ekudleni kwakho kwansuku zonke.

Umthombo: Li Yiqun, Zhou Nianbo. Imisebenzi ye-Biology kanye Nezicelo ze-EGT [J]. Ukudla Kwezobunjiniyela, 2010 chuma9 (3) : 26-28.

Ukufakwa kuhlu kubhalwe kanjena:

Izingane (iminyaka emi-3 kuya kwe-11) ≤l 0 mg / usuku
Ubusha (iminyaka eyi-11-21) ≤30 mg / usuku
Abantu abadala (iminyaka engama-21-80) ≤30 mg / usuku

Qaphela: 1. Imithamo yezingane nabantu abadala (iminyaka engu-3 -80 ubudala)

           Ukusetshenziswa kwabesifazane abakhulelwe noma abancelisayo akunconyiwe.

Umthombo wedatha: I-Tetrahedron lapho ufaka isicelo se-US NDI

Imininingwane iphakamisa: 10.5mg / g ye-OXIS's ADI (Ukwamukelwa Kwansuku Zonke Okumukelekile).

 

③ ISYNTHESIS

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UKWANDISWA NOKUSETSHENZISWA

(1) ISIQEPHU

Njengamanje, kunezindlela ezintathu zokukhiqizwa kwe-EGT: synthesis synthesis, zemvelo ukukhishwa kwe-bio (ikakhulukazi kusuka kumakhowe, izicubu zezilwane nokukhishwa kwegazi), kanye nendlela ye-biosynthesis.

Ukuqhathaniswa kokukhishwa kwe-EGT izindlela

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(2) ISICELO

I-EGT inezicelo ezibanzi kuzimonyo, ukudla okusebenzayo, imithi yokwelapha, imithi yokwelapha, i-biomedicine, njalonjalo.

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(3) EZINYE IZICELO EZIKHONA

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Okubhekwayo

  1. I-Oleoylethanolamide (oea) –i-wand yemilingo yempilo yakho
  2. I-Anandamide vs cbd: yikuphi okungcono empilweni yakho? Konke odinga ukukwazi ngabo!
  3. Konke odinga ukukwazi mayelana ne-nicotinamide riboside chloride
  4. Izithasiselo ze-Magnesium l-threonate: izinzuzo, isilinganiso, nemiphumela emibi
  5. I-Palmitoylethanolamide (ipea): izinzuzo, isilinganiso, ukusetshenziswa, ukwengeza
  6. Izinzuzo eziphezulu zezempilo eziyi-6 zezengezo ze-resveratrol
  7. Izinzuzo ezi-5 eziphezulu zokuthatha i-phosphatidylserine (ps)
  8. Izinzuzo ezi-5 eziphezulu zokuthatha i-pyrroloquinoline quinone (pqq)
  9. Isengezo esihle kakhulu se-alpha gpc
  10. Isengezo esihle kakhulu sokulwa nokuguga se-nicotinamide mononucleotide (nmn)

 

Isihloko ngu: UDkt. Zeng

Isihloko ngu:

UDkt Zeng

Co-founder, ubuholi benkampani obuyinhloko bokuphatha; I-PhD itholwe kuFudan University ku-organic chemistry. Isipiliyoni seminyaka engaphezu kwengu-10 ku-organic chemistry kanye nokwakhiwa kwezidakamizwa synthesis; Cishe amaphepha ocwaningo ayishumi ashicilelwe emaphephandabeni anegunya, anamalungelo obunikazi angaphezu kwamahlanu aseChina.

 

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