Yini i-Anandamide (AEA)

I-Anandamide (AEA), eyaziwa nangokuthi i-molecule yenjabulo, noma N-arachidonoylethanolamine (I-AEA), i-fatty acid neurotransmitter. Igama elithi Anadamida (AEA) lisuselwa kweleSanskrit of Joy “Ananda.” URaphael Mechoulam waqamba leli gama. Ukuthi, kanye nabasizi bakhe ababili, uWA Devane noLumír Hanuš, bathola kanjani okokuqala i- “Anandamide” ngo-1992. I-Anandamide (AEA) iyisilungiso esihle sezinkinga eziningi zomzimba nezengqondo.

Yini iCannabidiol (CBD)?

I-Cannabidiol (i-CBD) iyinhlanganisela yesibili esebenzayo kakhulu eyaziwa ngokuthi ama-cannabinoids atholakala ku- i-cannabis sativa (insangu noma i-hemp). I-Tetrahydrocannabinol (iTHC) yiyona edlange kakhulu futhi futhi iyi-cannabinoid ethinta ingqondo kakhulu etholakala esitshalweni se-cannabis. I-THC ihlotshaniswa nokuzwa ukuzwa "okuphezulu".
Kodwa-ke, i-CBD ayisebenzi ngokomqondo futhi itholakala esitshalweni se-hemp esiqukethe inani eliphansi le-THC. Le mpahla yenze i-CBD yathola ukuthandwa emkhakheni wezempilo nenhlalakahle.
Ngakolunye uhlangothi uwoyela weCannabidiol (CBD) utholakala esitshalweni se-cannabis ngokungeza i-CBD ekhishiwe kumafutha athwala njenge-hemp seed oil noma uwoyela kakhukhunathi.

I-Anandamide ne-Cannabidiol FAQ

Yini i-Anandamide?

I-Anandamide, eyaziwa nangokuthi i-N-arachidonoylethanolamine, iyi-fatty acid neurotransmitter etholakala kwimetabolism engeyona ye-oxidative ye-eicosatetraenoic acid, i-omega-6 fatty acid ebalulekile. Leli gama lisuselwa egameni lesiSanskrit elithi ananda, elisho ukuthi “injabulo, intokozo, injabulo”, naphakathi.

Ingabe i-anandamide yi-hormone?

Ucwaningo luhlinzeka ngesixhumanisi sokuqala phakathi kwe-oxytocin - ebizwa ngokuthi "i-hormone yothando" - ne-anandamide, eye yabizwa ngokuthi "i-molecule yenjabulo" ngendima yayo ekusebenzeni ama-cannabinoid receptors kumaseli obuchopho ukukhulisa ugqozi nenjabulo.

Ingabe i-anandamide iyajabulisa noma iyavimbela?

Ekuphetheni, ama-cannabinoid receptors ohlobo lwe-CB1 kanye ne-ligand yawo engapheli, i-anandamide, ayabandakanyeka ekulawuleni i-neuronal excitability, ngaleyo ndlela anciphise ukuhanjiswa kwe-neurotransmission kusayithi le-presynaptic, indlela engabandakanyeka ekuvikeleni ukujabula ngokweqile okuholela .

Yimaphi ama-endocannabinoids amabili acwaningwe kakhulu akhiqizwa ngumzimba ngokwemvelo?

Abaphenyi bacabanga ukuthi kungenzeka kube khona i-receptor yesithathu ye-cannabinoid elinde ukutholakala. Ama-endocannabinoids yizinto ezenziwe yimizimba yethu ukukhuthaza la ma-receptors. Ama-molecule amabili aqondakala kahle kakhulu abizwa nge-anandamide ne-2-arachidonoylglycerol (2-AG).

Ngabe umzimba womuntu unohlelo lwe-cannabinoid?

Uhlelo lwe-cannabinoid olungapheli — olubizwa ngesitshalo esiholele ekutholeni kwalo — lungesinye sezinhlelo ezibaluleke kakhulu zomzimba ezibandakanyeka ekusunguleni nasekugcineni impilo yabantu. Ama-Endocannabinoids nama-receptors awo atholakala kuwo wonke umzimba: ebuchosheni, ezithweni, kwezicubu ezihlangene, kwizindlala, nakumaseli omzimba.

Iyini i-cannabinoid yokuqala etholakele?

Ngo-1992, ilebhu kaMechoulam yahlukanisa i-endocannabinoid yokuqala: i-molecule ekugcineni eyahlukaniswa njenge-agonist ye-CB1 receptor. Kwakhonjwa njenge-arachidonoyl ethanolamide kwathiwa i-anandamide.

Ingabe i-anandamide ushokoledi?

I-THC, noma kunjalo, ayitholakali kushokoledi. Esikhundleni salokho, elinye ikhemikhali, i-neurotransmitter ebizwa nge-anandamide, likhishwe ngoshokoledi. Kuyathakazelisa ukuthi i-anandamide nayo ikhiqizwa ngokwemvelo ebuchosheni.

Ingabe ushokoledi yi-cannabinoid?

I-Anandamide ibizwa nge-endocannabinoid ngoba yenziwa ngumzimba wethu futhi ilingisa ama-cannabinoids atholakala esitshalweni sensangu. Ngakho-ke, isithako sikashokolethi nesithako esitshalweni sensangu zombili ziyakwazi ukuvuselela uhlelo lobuchopho bethu lwensangu lwe-neurotransmitter.

Ngabe ushokoledi unayo i-theobromine?

I-Theobromine yi-alkaloid eyinhloko etholakala ku-cocoa noshokoledi. I-cocoa powder ingahluka enanini le-theobromine, kusuka ku-2% theobromine, kuze kufike kumazinga aphezulu azungeze i-10%. … Ngokuvamile kunokugxila okuphezulu ebumnyameni kunoshokoledi wobisi.

Yimaphi ama-cannabinoids ajwayelekile kakhulu?

Lezi zinhlayiya ezimbili eziyinhloko yi-delta-9-tetrahydrocannabinol (THC) ne-cannabidiol (CBD). Okwaziwa kakhulu kulaba ababili yi-delta-9-tetrahydrocannabinol (THC), okuyikhemikhali elibhekele imiphumela yengqondo ye-cannabis.

Yini i-molecule yenjabulo?

I-Anandamide yikhemikhali yobuchopho engaziwa kancane ebizwa ngokuthi “i-molecule yenjabulo” ngendima eliyidlalayo ekukhiqizeni imizwa yenjabulo. … Isebenza ngokubophezela kuma-receptors afanayo ebuchosheni njengenhlanganisela eyinhloko ye-psychoactive ensangu.

Ingabe i-anandamide isidakamizwa?

I-Anandamide, i-ligand engapheli yobuchopho be-cannabinoid CB1 receptors, ikhiqiza imiphumela eminingi yokuziphatha efana naleyo ye-Δ9-tetrahydrocannabinol (THC), isithako esiyinhloko se-psychoactive ensangu.

Ngabe umzimba womuntu ukhiqiza ama-cannabinoids?

Ama-Endocannabinoids. Ama-endocannabinoids, abizwa nangokuthi ama-cannabinoid endogen, angama-molecule enziwe ngumzimba wakho. Ziyafana nama-cannabinoids, kepha akhiqizwa ngumzimba wakho.

Ingabe i-CBD iyayinyusa i-dopamine?

I-CBD futhi ivuselela i-adenosine receptor ukukhuthaza ukukhishwa kwe-glutamate ne-dopamine neurotransmitters. Ngokusebenzisana kwayo nama-dopamine receptors, kuyasiza ukukhulisa amazinga e-dopamine futhi kulawulwe ukuqonda, ukugqugquzela, nokuziphatha okufuna umvuzo.

Ingabe i-Indica ikhulisa i-dopamine?

kunciphisa ubuhlungu obukhulu. kwandisa isifiso sokudla. kwandisa i-dopamine (i-neurotransmitter esiza ukulawula umvuzo wobuchopho nezikhungo zobumnandi) ekusebenziseni isikhathi sasebusuku.

Uhlobo luni lwesidakamizwa ushokoledi?

Ngaphezu koshukela, ushokoledi unezinye izidakamizwa ezimbili ezine-neuroactive, i-caffeine ne-theobromine. Ushokoledi awugcini nje ngokuvuselela ama-opiate receptors ebuchosheni bethu, futhi ubangela nokukhishwa kwama-neurochemicals ezikhungweni zobumnandi bobuchopho.

Yini i-anandamide eyenzayo emzimbeni?

Imizimba yethu idala i-anandamide ngokufunwayo, ezosetshenziswa lapho kudingeka khona ukugcina i-homeostasis. I-Anandamide ikwenza lokhu ngokusiza ukulawula ukuvuvukala nokusayina kwe-neuron. Njengoba idaliwe, ibopha ngokuyinhloko ngama-cannabinoid receptors CB1 ne-CB2 njengama-cannabinoids afana ne-THC uma engenwa.

Luthini uhlelo lwe-cannabinoid receptor?

Ama-receptors e-Cannabinoid, atholakala kuwo wonke umzimba, ayingxenye yohlelo lwe-endocannabinoid, olubandakanyeka ezinqubweni ezahlukahlukene zomzimba kubandakanya ukuthanda ukudla, ukuzwa ubuhlungu, imizwa nenkumbulo. Ama-receptors e-Cannabinoid asekilasini lama-receptor membrane weseli kumndeni omkhulu we-G protein-coupled receptor.

Yimaphi amaqembu ahlukene asebenzayo akhona ku-anandamide?

Amaqembu asebenzayo e-Anandamide afaka ama-amide, ama-esters, nama-ether we-long chain chain polyunsaturated fatty acids, futhi ahlanganyela ngokuhlelekile ngama-pharmacophores abucayi ne-D-9-tetrahydrocannabinol (THC).

Wanyusa kanjani amazinga e-anandamide ngokwemvelo?

Yidla ukudla okunothile kulezi zithelo futhi uvimbele ukukhiqizwa kwakho kwe-FAAH okwandisa amazinga akho e-anandamide! Ushokoledi okunye ukudla okungasiza ukukhulisa i-anandamide. Inenhlanganisela eyaziwa ngokuthi i-ethylenediamine evimbela ukukhiqizwa kwe-FAAH. Gcina lokhu kudla okuthathu engqondweni ngokuzayo lapho ungena esitolo.

Ngabe ushokoledi uqukethe i-anandamide?

I-THC, noma kunjalo, ayitholakali kushokoledi. Esikhundleni salokho, elinye ikhemikhali, i-neurotransmitter ebizwa nge-anandamide, likhishwe ngoshokoledi. Kuyathakazelisa ukuthi i-anandamide nayo ikhiqizwa ngokwemvelo ebuchosheni.

Ingabe ushokoledi umuthi?

Ushokoledi unenani elikhulu loshukela. Ngaphezu koshukela, ushokoledi unezinye izidakamizwa ezimbili ezine-neuroactive, i-caffeine ne-theobromine. Ushokoledi awugcini nje ngokuvuselela ama-opiate receptors ebuchosheni bethu, futhi ubangela nokukhishwa kwama-neurochemicals ezikhungweni zobumnandi bobuchopho.

Uyini umuthi kushokoledi?

I-Theobromine yi-alkaloid eyinhloko etholakala ku-cocoa noshokoledi.

Iyiphi ikhemikhali ekhona kushokoledi?

I-Theobromine, phambilini ebiyaziwa nge-xantheose, iyi-alkaloid ebabayo yesitshalo sekhokho, nefomula yamakhemikhali C7H8N4O2. Kutholakala kushokoledi, kanye nakokunye ukudla okuningi, kufaka phakathi amaqabunga esitshalo setiye, ne-kola nut.

Ingabe ushokoledi uyayinyusa i-serotonin?

Kodwa-ke, ngoba ushokoledi uqukethe i-tryptophan, ukwanda okuvelayo kwe-serotonin kungasiza ekuchazeni ukuthi kungani umuntu engazizwa ejabule, ezolile, noma ekhathazekile kancane ngemuva kokudla ucezu lwekhekhe labo le-chocolate (iSerotonin).

Yini i-anandamide ebhekene nayo?

I-Anandamide idlala indima ekulawulweni kokuziphatha kokondla, kanye nesizukulwane se-neural sesisusa nenjabulo. I-Anandamide ejojowe ngqo ku-forebrain ehlobene nomvuzo wokwakheka kobuchopho i-nucleus accumbens ithuthukisa izimpendulo ezijabulisayo zamagundane ekunambithekeni okunomvuzo kwe-sucrose, futhi ithuthukise nokudla.

Ingabe i-CBD iyi-antioxidant?

I-THC ne-CBD zingama-antioxidants anamandla — anamandla kakhulu kuno-vitamin C no-E. Eqinisweni, i-US Government Patent 1999/008769 iqondene ngqo nezakhi ze-neuroprotectant ne-antioxidant zama-cannabinoids.

Yenzani i-enzyme ye-FAAH?

I-fatty acid amide hydrolase (i-FAAH) iyi-enzyme ehlanganisa ulwelwesi lwe-mammalian eyehlisa umndeni we-fatty amide we-endo native signaling lipids, ofaka i-endo native cannabinoid anandamide kanye ne-oceamide eyenga ubuthongo.

I-CBD iyithinta kanjani i-anandamide?

Ucwaningo lwe-Biochemical lubonisa ukuthi i-cannabidiol ingakhulisa ukusayina kwe-anandamide okungaqondile ngokungaqondile, ngokuvimbela ukonakala kwe-intracellular kwe-anandamide okwenziwe yi-enzyme fatty acid amide hydrolase (FAAH).

Kusho ukuthini i-cannabinoid?

Igama i-cannabinoid libhekisa kuzo zonke izinto zamakhemikhali, noma ngabe zakhiwe kanjani noma zivelaphi, ezijoyina izamukeli ze-cannabinoid zomzimba nobuchopho futhi ezinemiphumela efanayo kulezo ezikhiqizwa isitshalo seCannabis Sativa. … Izidakamizwa ezimbili eziyinhloko i-delta-9-tetrahydrocannabinol (THC) ne-cannabidiol (CBD).

Luyini uhlelo lwe-endocannabinoid futhi lwenzani?

Umzimba womuntu uqukethe uhlelo olukhethekile olubizwa nge-endocannabinoid system (ECS), olubandakanyekayo ekulawuleni imisebenzi ehlukahlukene kubandakanya ukulala, isifiso sokudla, ubuhlungu nokuphendula amasosha omzimba.

Ngabe umzimba unama-receptors we-cannabinoid?

Ama-receptors e-Cannabinoid, atholakala kuwo wonke umzimba, ayingxenye yesistimu ye-endocannabinoid, ebandakanyeka ezinqubweni ezahlukahlukene zomzimba kubandakanya ukuthanda ukudla, ukuzwa ubuhlungu, imizwa nenkumbulo. … Ngo-2007, ukuboshwa kwama-cannabinoids amaningana ku-G protein-coupled receptor GPR55 ebuchosheni kwachazwa.

Ingabe i-CBD inyusa i-anandamide?

Ngokuya ngemiphumela encike ekutholakaleni kwe-cannabinoid ye-CBD kumthethonqubo wokwesaba ofundile ochazwe ngenhla, i-CBD inyusa amazinga e-anandamide ngokuvimbela ukuphinda kutholakale futhi kulinyazwe i-FAAH.

Yikuphi i-cannabinoid esetshenziselwa ukukhathazeka?

Ngomthamo ophansi we-THC kanye nomthamo olinganiselayo we-CBD, iphrofayili ye-cannabinoid kaHarlequin ilungele kahle labo abalwa nezinkathazo abangenandaba nokujabula. I-terpene yayo eningi kakhulu i-myrcene, okukholelwa ukuthi inomphumela wokuphumula futhi isetshenziswe kuwo wonke umlando njengosizo lokulala.

Ingabe i-CBD iyasiza ukukhathazeka?

I-CBD ijwayele ukusetshenziselwa ukubhekana nokukhathazeka, kanye neziguli ezihlupheka ngenxa yokuswela ukuqwasha, ucwaningo lukhombisa ukuthi i-CBD ingasiza kubo bobabili ukulala nokulala. I-CBD inganikela ngenketho yokwelapha izinhlobo ezahlukene zobuhlungu obungapheli.

Ingabe utshwala buyasiza ukukhathazeka?

Utshwala buyisidambisi futhi buyacindezela obuthinta uhlelo oluphakathi lwezinzwa. Ekuqaleni, ukuphuza kunganciphisa ukwesaba futhi kususe ingqondo yakho ezinkingeni zakho. Kungakusiza uzizwe unamahloni kancane, kukunikeze amandla okuqina, futhi kukwenze uzizwe ukhululekile ngokujwayelekile.

Ngithola kanjani ukuthi nginexhala?

Ukuthola isifo sokukhathazeka, udokotela wenza ukuhlolwa komzimba, abuze ngezimpawu zakho, futhi ancoma ukuhlolwa kwegazi, okusiza udokotela ukuthi anqume ukuthi ngabe esinye isimo, njenge-hypothyroidism, kungenzeka yini sidala izimpawu zakho. Udokotela angabuza futhi nganoma imiphi imithi oyiphuzayo.

Yiziphi izidakamizwa okungafanele zithathwe nge-CBD?

  • Ama-anti-depressants (njenge-fluoxetine, noma i-Prozac)
  • Imithi engadala ukozela (i-antipsychotic, benzodiazepines)
  • Ama-antibiotic e-Macrolide (i-erythromycin, i-clarithromycin)
  • Imithi yenhliziyo (ezinye izivimbeli zesiteshi se-calcium)

Ingabe i-CBD iyayikhipha i-dopamine?

I-CBD futhi ivuselela i-adenosine receptor ukukhuthaza ukukhishwa kwe-glutamate ne-dopamine neurotransmitters. Ngokusebenzisana kwayo nama-dopamine receptors, kuyasiza ukukhulisa amazinga e-dopamine futhi kulawulwe ukuqonda, ukugqugquzela, nokuziphatha okufuna umvuzo.

Izizwa kanjani i-dopamine ephansi?

Ezinye izimpawu nezimpawu zezimo ezihlobene nokushoda kwe-dopamine zifaka: amajaqamba emisipha, ama-spasms, noma ukuthuthumela. izinhlungu nezinhlungu. ukuqina emisipheni.

Ingabe i-caffeine inyusa amazinga e-dopamine?

I-caffeine, into esetshenziswa kakhulu ukusebenzisa izinto ezithikameza umzimba emhlabeni, isetshenziselwa ukukhuthaza ukuphaphama nokwenza ngcono ukuqapha. Njengezinye izidakamizwa ezikhuthaza ukuvusa (izikhuthazi kanye ne-modafinil), i-caffeine ithuthukisa ukusayina kwe-dopamine (DA) ebuchosheni, ekwenza kakhulu ngokulwa nama-adenosine A2A receptors (A2AR).

Iyiphi indlela esheshayo yokwengeza i-dopamine?

  • Yidla Amaprotheni amaningi
  • Yidla Amafutha Angagcwali
  • Sebenzisa ama-Probiotic
  • Yidla ubhontshisi weVelvet
  • Vocavoca Ngokuvamile
  • Thola Ukulala Okunene
  • Lalela umculo
  • Zindla
  • Thola Ilanga Elanele
  • Cabanga ngama-Supplements

Ingabe i-CBD iyasiza ukukhathazeka?

I-CBD ijwayele ukusetshenziselwa ukubhekana nokukhathazeka, kanye neziguli ezihlupheka ngenxa yokuswela ukuqwasha, ucwaningo lukhombisa ukuthi i-CBD ingasiza kubo bobabili ukulala nokulala. I-CBD inganikela ngenketho yokwelapha izinhlobo ezahlukene zobuhlungu obungapheli.

Ingabe i-CBD iphakamisa i-serotonin?

I-CBD ayikhuphuli amazinga e-serotonin, kepha ingathinta indlela ama-receptors akho obuchopho asebenza ngayo kwi-serotonin esivele isesistimu yakho. Ucwaningo lwesilwane lwango-2014 luthole ukuthi umphumela we-CBD kulawa ma-receptors ebuchosheni ukhiqize imiphumela yokulwa nokucindezelwa nokulwa nokukhathazeka.

Ingabe i-CBD ingakusiza ubuchopho bakho?

Abaphenyi bakholelwa ukuthi ikhono le-CBD lokwenza ngokusebenza kohlelo lwe-endocannabinoid kanye nezinye izinhlelo zokufaka uphawu ebuchosheni kunganikeza izinzuzo kulabo abanezifo zemizwa. Eqinisweni, okunye kokusetshenziswa okufundwe kakhulu kwe-CBD ekwelapheni ukuphazamiseka kwemizwa okufana nesifo sokuwa kanye ne-multiple sclerosis.

Ngingawakhuphula kanjani amazinga e-serotonin?

  • Ukudla
  • Ukuzivocavoca
  • Ukukhanya okukhanyayo
  • supplements
  • Massage
  • Ukungeniswa kwemizwelo

Yimuphi uwoyela we-CBD ongcono kakhulu ongawuthenga ngokunciphisa umzimba?

I-Anandamide ngumlamuleli we-lipid osebenza njenge-ligo engapheli ye-CB1 receptors. Lawa ma-receptors nawo ayilitshe eliyinhloko lamangqamuzana elibhekele imiphumela yemithi ye-Δ9-tetrahydrocannabinol, isithako se-psychoactive ku-Cannabis sativa.

Uyenza kanjani i-anandamide?

Ihlanganiswe kusuka ku-N-arachidonoyl phosphatidylethanolamine ngezindlela eziningi. Kwehliswe ngokuyinhloko yi-enzyme enamafutha e-fatty acid amide hydrolase (FAAH), eguqula i-anandamide ibe yi-ethanolamine ne-arachidonic acid.

Ingabe umzimba womuntu uyayikhiqiza i-CBD?

Ongase ungakuqapheli, nokho, ukuthi lokhu kulandela iqiniso lokuthi umzimba womuntu empeleni ukhiqiza ama-cannabinoid awo angapheli: okufana nemvelo kwamakhemikhali atholakala esitshalweni se-cannabis, njenge-THC (tetrahydrocannabinol) ne-CBD (cannabidiol).

Ingabe i-CBD inkulu kangako?

Abukho ubufakazi, ngokwesibonelo, bokuthi i-CBD ilapha umdlavuza. Kunobufakazi obulinganiselayo bokuthi i-CBD ingathuthukisa ukuphazamiseka kokulala, ubuhlungu be-fibromyalgia, ukuqina kwemisipha okuhlobene ne-multiple sclerosis nokukhathazeka. UDkt Levy uthi: “Inzuzo engiyibone njengodokotela kakhulu ekwelapheni izinkinga zokulala, ukukhathazeka nobuhlungu.

Ingabe imikhiqizo ye-CBD iphephile?

Ukusetshenziswa kwe-CBD kubuye kube nezingozi ezithile. Yize kuvame ukubekezelelwa kahle, i-CBD ingadala imiphumela emibi, njengomlomo owomile, isifo sohudo, ukunciphisa ukudla, ukozela nokukhathala. I-CBD ingaphinde ihlanganyele neminye imithi oyiphuzayo, efana nabanciphisi begazi.

Yenzani i-CBD ebuchosheni?

Lezi zimfanelo zixhunyaniswe nekhono le-CBD lokwenza ngokuthola ama-receptors ebuchosheni be-serotonin, i-neurotransmitter elawula imizwa nokuziphatha komphakathi. Isifinyezo Ukusebenzisa i-CBD kukhonjisiwe ukunciphisa ukukhathazeka nokudangala ezifundweni zabantu nezilwane.

I-CBD ishiya ngokushesha kangakanani uhlelo?

I-CBD ihlala ohlelweni lwakho izinsuku ezi-2 ukuya kwezi-5, kepha lelo banga alisebenzi kuwo wonke umuntu. Kwabanye, i-CBD ingahlala ohlelweni lwayo amasonto.

I-anandamide itholakalaphi?

I-Anandamide yenziwe nge-enzymatic ezindaweni zobuchopho ezibalulekile kwimemori, izinqubo zokucabanga nokulawulwa kokuhamba. Ucwaningo luphakamisa ukuthi i-anandamide idlala indima ekwenziweni nasekuqhekekeni kokuxhumeka kwesikhashana phakathi kwamangqamuzana ezinzwa, futhi lokhu kuhlobene nokufunda nokukhumbula.

Ingabe i-anandamide iyi-cannabinoid?

Ebizwa nangokuthi i-N-arachidonoylethanolamine (AEA), i-anandamide ixhumana nama-receptors emzimbeni we-CB ngokufanayo kuma-cannabinoids afana ne-THC. I-ejenti ebophayo ye-neurotransmitter ne-cannabinoid-receptor esebenza njengesithunywa sesiginali sama-receptors e-CB asemzimbeni.

Isebenza kanjani i-Anandamide (AEA)

I-Anandamide (AEA) itholakala kwimetabolism engeyona ye-oxidative ye-eicosatetraenoic acid. I-Anandamide (i-AEA) ingumlamuleli we-lipid futhi isebenza njenge-ligo engapheli yama-receptors e-CB1 futhi iguqule ukujikeleza kwayo komvuzo. Kuyi-neurotransmitter ebalulekile ohlelweni lwe-endocannabinoid, eqanjwe ngeCannabis. Kuyasiza ukulawula ukuhamba kwezinhlelo ze-neurochemical ukugcina umzimba nengqondo yakho kusebenza kahle. Kutholakala ukuthi isakhiwo se-Anandamide siyefana ne-tetrahydrocannabinol (THC), okuyisakhi esiyinhloko se-psychotic se-Cannabis. Ngakho-ke i-Anandamide iguqula imizwa ifanisa lokho okwaziwa kakhulu njengeCannabis high.

Kukhiqizwa ngokwemvelo emzimbeni wethu njengokuyalelwa ubuchopho ngokuphendula kwe-condensation kuma-neurons. Ukuphendula kwe-condensation okulawulwa yi-calcium ion kanye ne-cyclic monophosphate adenosine kwenzeka phakathi kwe-arachidonic acid ne-ethanolamine.

I-Anandamide yandisa injabulo ngokusebenzisana nama-cannabinoid receptors ohlelweni lwezinzwa lwe-nervous and peripheral, CB1 ne-CB2. Ama-receptors e-CB1 abhekise ekusebenzeni kwezimoto (ukunyakaza) nokuxhumanisa, Ukucabanga, Ukudla, inkumbulo yamagama amafushane, Ukubona ubuhlungu, nokuzivikela. Ngasikhathi sinye, ama-receptors e-CB2 akhomba izitho ezinkulu ezifana neLiver, Gut, izinso, amaPancreas, izicubu ze-Adipose, imisipha yamathambo, ithambo, iso, izimila, uhlelo lokuzala, uhlelo lokuzivikela komzimba, umgudu wokuphefumula, isikhumba, uhlelo oluphakathi lwezinzwa, kanye nesistimu yenhliziyo. .

Emzimbeni wethu, i-N-arachidonoylethanolamine yehla ibe yi-fatty acid amide hydrolase (FAAH) enzyme futhi ikhiqize i-arachidonic acid ne-ethanolamine. Uma isenzo se-FAAH se-FAAH singanciphisa ijubane, singazuza izinzuzo zika-Anandamide's Anandamide isikhathi eside.

I-Anandamide (AEA)
I-Anandamide (AEA)

Isebenza kanjani iCannabidiol (CBD)?

Imizimba yethu iqukethe uhlelo olukhethekile olubizwa nge-endocannabinoid system olubhekele izinguquko zomzimba. Umzimba ukhiqiza ama-endocannabinoids uwodwa. I-endocannabinoid ngama-neurotransmitters abopha kuma-cannabinoid receptors.

Kukhona ama-receptors amabili e-cannabinoid; Ama-CB1 nama-CB2 receptors. Ama-receptors e-CB1 atholakala emzimbeni wonke futhi ikakhulukazi ebuchosheni. Zilawula imizwa yakho, imizwa, ukunyakaza, isifiso sokudla, inkumbulo, nokucabanga kwakho.

Ama-receptors we-CB 2 ngakolunye uhlangothi atholakala kumasosha omzimba futhi athonya ukuvuvukala nobuhlungu.

Ngenkathi iTHC ibopha ngokuqinile kuma-receptors e-CB1, i-CBD ayibophi kakhulu kuma-receptors kepha kunalokho ivuselela umzimba ukuthi ukhiqize ama-endocannabinoids amaningi. I-CBD nokho ingabopha noma isebenze amanye ama-receptors afana ne-serotonin receptor, vanilloid, nama-PPARs [i-peroxisome proliferator-activated receptors] receptors. I-CBD nayo isebenza njengomphikisi kuma-receptors ayizintandane e-GPR55.

I-CBD ibopha i-serotonin receptor ethintekayo ekukhathazekeni, ekulaleni, ekuboneni izinhlungu, isifiso sokudla, isicanucanu nokuhlanza.

I-CBD ibopha ne-vanilloid receptor eyaziwa ngokulamula izinhlungu, ukuvuvukala nokushisa komzimba.

I-CBD kodwa isebenza njengomphikisi ku-GPR55 receptor evame ukuvezwa ezinhlotsheni ezahlukahlukene zomdlavuza.

I-Cannabidiol nayo isebenza njenge-anti-inflammatory agent. Iyalwa noma inciphisa ukuvuvukala.

I-Cannabidiol nayo inezakhiwo ze-antioxidant ezikwenza ikwazi ukuqeda ama-radicals amahhala avame ukuhlotshaniswa nokuphazamiseka okonakala.

Izinzuzo ze-Anandamide (AEA)

I-Anandamide (AEA) ilingisa imiphumela yeCannabis kusistimu yethu, ngaphandle kwemiphumela yayo emibi. I-Anandamide isisiza ngokuvuselela ubuchopho bethu ngezindlela ezilandelayo:

I-Anandamide (AEA)

① Ukwandisa amandla obuchopho nememori

Ukuthuthukisa amandla akho ememori yokusebenza kuyinto enkulu Izinzuzo ze-Anandamide (AEA). Futhi kukusiza ukuthi ube nobuciko ngokwengeziwe ngokucubungula imininingwane ibe yimibono emisha. Ucwaningo kumagundane lukhombise ukuthuthuka okuphawulekayo ekusebenzeni kobuchopho. Ngakho-ke uma ufuna ukuthuthukisa amakhono akho okuhlaziya, amakhono okudala, noma wenze kahle ezifundweni zakho, i-Anandamide ikhambi eliphelele.

② Isebenza njengesilawuli sesifiso sokudla

Uma ufuna ukulandela ukudla okuqinile, ukulawulwa kwesifiso kuyadingeka. Enye yezinzuzo ze-Anandamide kungakusiza ukuthi ulawule imijikelezo yesifiso sokudla nokusutha. Ungakwazi ukulawula kalula ubuhlungu bendlala noma izifiso ze-junk ngosizo lwe-Anandamide. Ngale ndlela, ungafinyelela izinhloso zakho zokulahlekelwa isisindo noma izinhloso zokuphinda uthole ukwakheka. Ezinsukwini zanamuhla ukuhlala uphilile futhi ulungile kuncike kakhulu emikhubeni yethu yokudla, futhi izithako ze-Anandamide zingasisiza. Kepha izinhlelo zokunciphisa isisindo nge-Anandamide kufanele zihambisane nezinhlelo ezifanele zokudla. Ukweqa ngokweqile kungaholela ekulahlekelweni okungazelelwe kwesisindo somzimba futhi, ngaleyo ndlela, kube nezinkinga zemetabolism. Futhi, esimweni somama abancelisayo, ukusetshenziswa kwe-Anandamide kudinga ukugwenywa. (5)(2015). I-Cannabidiol (i-CBD) kanye nama-analogs ayo: ukubuyekezwa kwemiphumela yokuvuvukala.

③ Neurogeneis

Enye indlela yokwandisa umthamo wakho wokusebenza kobuchopho ukuthi ube nama-neurons amasha noma amangqamuzana obuchopho nge-Neurogenesis. Lokhu kuyiqiniso, ikakhulukazi ususondele ku-40 noma usudlule iminyaka yobudala. I-Anandamide (AEA) iyasiza ku-Neurogenesis.

Ngaphezu kwalokho, amazinga aphezulu amazinga e-Anandamide emzimbeni womuntu aqeda ubungozi bezifo ezingenayo i-neurodegenerative njengesifo sikaPerkinson'sPerkinson, njll. Lapho esemdala, i-Anandamide isiza ekululameni ezinkingeni ezihlobene ne-neurodegeneration njengokulahleka kwememori, ukudangala, ukwesaba, ukungabi namandla umzimba, njll. I-Anandamide (AEA) isiza abantu abadala asebekhulile ukuba bajabulele impilo yabo ethathe umhlalaphansi ngaphandle kokukhathazeka ngezinkinga zabo zezempilo.

I-Anandamide (AEA)

Roll Ukulawula Izifiso Zocansi

Izinzuzo ze-Anandamide (AEA) zilawula isifiso sakho sobulili ngezindlela ezimbili. Ngomthamo omnene, ithuthukisa izifiso zocansi. Kepha ngomthamo osindayo we-Anandamide (AEA) unciphisa isifiso sobulili. I-Anandamide (i-AEA) ithuthukisa imizwa yakho futhi iqede ukucindezeleka okunika isifiso sobulili. Kepha umthamo ophakeme ukukwenza waneliseke ngokocansi, futhi awutholi sidingo sokwenza ucansi.

I-Anandamide (AEA)

Properties Izakhiwo ezilwa nomdlavuza

I-Anandamide (i-AEA) inezakhiwo ze-ant carcinogenic ngokusebenzisa imiphumela ye-psychotropic. I-Anandamide (AEA) ilwa nokukhula kwezicubu ezinomdlavuza. Kuzuzisa ikakhulukazi umdlavuza webele. Ukuhlolwa kukhombisa ukuthi kungaba indawo enhle yemithi ejwayelekile yomdlavuza. Ngaphezu kwalokho, ayinayo imiphumela emibi uma iqhathaniswa nemiphumela eguqula impilo yemithi ejwayelekile yomdlavuza. Ngakho-ke kungekudala, ukwamukelwa okukhulu kwe-Anandamide (AEA) kunganciphisa ubuhlungu ezigulini ezinomdlavuza ezidlula kubo ngesikhathi sokwelashwa.

Izici ze-antiemetic

I-nausea nokuhlanza nakho kungalawulwa nge-Anandamide (AEA). Isebenza ne-serotonin ukulawula isicanucanu. Lokhu kwenza i-Anandamide (AEA) isisombululo se-antiemetic ngesikhathi samakhemikhali ezigulini zomdlavuza. Lokhu kungaba kuhle nakomama abakhulelwe. Kepha esimweni somama abakhulelwe, i-Anandamide (AEA) kufanele yenziwe kuphela uma kunconywa udokotela wakhe.

Izakhiwo Zokusiza Ubuhlungu

Ngokuhlangana ne-CB1, i-Anandamide (AEA) ivimba ukudluliswa kwezimpawu zobuhlungu. Ngale ndlela, i-Anandamide (AEA) ingasetshenziselwa ukukhululeka kobuhlungu obungapheli ezigulini ezinesimo sezokwelapha njenge-gout, i-arthritis, noma i-sciatica. Eminyakeni yobudala, ubuhlungu buhlala buhambisana. I-Anandamide (AEA) iyikhambi eliqinisekisiwe lemigraines nezinye izinhlungu zekhanda ezinzima. Ukusetshenziswa kwezithako ze-Anandamide (AEA) ekugugeni kungabasiza ukuthi banqobe ubuhlungu futhi kuzothuthukisa nempilo yabo.

I-Anandamide (AEA)

Reg Isilawuli Se-Mood

Uhlelo lwe-endocannabinoid lulawula imizwa yethu. I-Anandamide (AEA) ilawula izingqondo zethu ezingezinhle njengokwesaba, ukukhathazeka, futhi yandisa injabulo. Ngale ndlela, i-Anandamide (AEA) ingasebenza njenge-up up lifter, ithuthukise impilo yengqondo, futhi ithuthukise ingaphakathi lakho. Njengoba izithasiselo ze-Anandamide (AEA) zingewona umlutha, kunconywa kakhulu, ikakhulukazi kubantu abaneminyaka yokusebenza, abadinga ukuqhubeka nokusebenza ngokukhiqiza okuphezulu endaweni enzima kakhulu nengcindezelayo.

I-Anandamide (AEA)

Ukulwa nokudangala

I-Anandamide (AEA) nayo ingalwa nayo ukucindezeleka. Ucwaningo olwenziwe kumagundane lusanda kufakazela ukuthi lunezimpawu zokucindezelwa. Ukudana kanye nezinkinga ezihlobene nakho kuyayilimaza impilo yethu yengqondo nengokwenyama… ngisho nasemphakathini wethu. Umlutha we-nicotine, utshwala, ukusebenzisa kabi izidakamizwa kuvame ukuhlanganiswa nokudangala. Izimo ezinzima kakhulu zingaholela ekutheni abantu bazibulale. Ukudana komoya kungaba namandla amabi akhuthazayo angaholela ngisho nasekufeni kwabantu. I-Anandamide (AEA) ingaba yisixazululo esihle kule nkinga.

⑩ Ukulwa Nokuvuvukala ne-Edema

I-Anandamide (AEA) inciphisa ukuvuvukala kweseli ne-edema. Ngale ndlela, kuyasiza futhi njengesixazululo sokulwa nokuvuvukala.

Ezinye izinzuzo

I-Anandamide (AEA) ingadlala indima enenzuzo ekuvuthweni nasekufakweni. Ucwaningo lukhombisa ukuthi amazinga aphezulu e-Anandamide (AEA) aqinisekisa ukuphuma kwe-ovulation ngempumelelo.

Abantu abangaphezu kwama-60% bazokhula umfutho wegazi ophezulu noma izifo ezingamahlalakhona zezinso. I-Anandamide (AEA) ingalinganisa imisebenzi yezinso ebanga lesi sifo. I-Anandamide (AEA) ikhombise imiphumela emihle ekuxazululeni izinkinga ezibangelwa umfutho wegazi ophakeme.

I-Anandamide (AEA) Imithombo Yemvelo

i.Black Truffles (isikhunta esimnyama)

Ama-Black Truffles aqukethe i-Anandamide yemvelo.

ii.Ulwandle namakhambi

I-cannabis, i-clove, isinamoni, i-pepper emnyama, i-oregano, njll. Ithuthukisa amazinga e-Anandamide emizimbeni yethu. Itiye lingumthombo omuhle kakhulu we-Anandamide (AEA).

iii) Ushokoledi

Ushokoledi omnyama ungomunye wemithombo emihle kakhulu ye-Anandamide. I-cocoa powder yakhiwe nge-oleolethanolamine ne-linoleoylethanolamine. Okuphansi ukwehla kwama-endocannabinoids futhi ngaleyo ndlela kugcinwe amazinga e-Anandamide emzimbeni wethu. Futhi, ushokoledi une-theobromine, esiza ukukhiqizwa kwe-Anandamide.

iv.Amafutha Acids Abalulekile

Amaqanda, imbewu yeChia, imbewu yefilakisi, isardadi, imbewu ye-hemp yimithombo emihle ye-endocannabinoid yokuqinisa okunamafutha acid. Ngokulandelayo, lokhu kuthuthukisa izinga le-Omega 3 ne-Omega 6 emzimbeni wethu kuthuthukisa umsebenzi we-endocannabinoid.

Izithasiselo ze-Anandamide (AEA) nezinye izindlela zokuthuthukisa amazinga we-Anandamide

I-CBD (i-Cannabidiol)

Enye yezindlela ezinhle kakhulu zokuvuselela uhlelo lwe-endocannabinoid ukusetshenziswa kwe-CBD. I-CBD ingumthombo omkhulu wensangu yezokwelapha. I-CBD ivimbela i-FAAH futhi ngaleyo ndlela ithuthukise amazinga e-Anandamide emzimbeni wethu.

Ukuzivocavoca

Ukuvivinya umzimba kuletha into enhle kithi. Ukuzivocavoca umzimba kuthuthukisa amazinga e-Anandamide emzimbeni futhi ngaleyo ndlela kwandise ukuthambekela kwakho kokuzivocavoca umzimba kanzima. Ukuhlola kukhombisa ukuthi ngemuva kokuzivocavoca, baba nokuzola futhi bangazweli ebuhlungwini. Lokhu kufanele ngenxa yokusebenza kwe-CB1 ne-CB2'sCB2 ngu-Anandamide. Kubonakala imizuzu engama-30 yokugijima okukhulu noma i-aerobics inyusa kakhulu amazinga e-Anandamide emizimbeni yethu. Kubuye kubonakale ukuthi imigraines iziguli ezithatha i-aerobics zivame ukubuyela esimeni esifanayo. Kungenxa yamazinga aphezulu we-Anandamide akhiqizwa emzimbeni wabo ngenxa yokuzivocavoca okunzima.

Ukunciphisa Ukucindezeleka

Abantu abakwazi ukulawula ukucindezeleka banezinga eliphakeme le-Anandamide kuzo. Ingcindezi inciphisa umphumela we-CB1 receptors futhi ngaleyo ndlela inciphise amazinga e-Anandamide futhi, nawo, akhombise ukunciphisa ukusebenza kwe-cannabinoid. Ngakho-ke gwema izimo ezicindezelayo ukuthuthukisa impilo yonke. Esinye sezixazululo ezinjalo ukuzindla.Ukulamula kuthuthukisa womabili amazinga we-Anandamide ne-dopamine emzimbeni wethu. I-Mediatbodiesleads iye emazingeni aphezulu we-oxytocin eqhubeka nokuthuthukisa amazinga we-Anandamide emzimbeni wethu. Kufana nomjikelezo omuhle wenhlalakahle. I-Anandamide ikusiza wehlise umoya futhi uzindle; Ukuzindla kuqhubeka nokuthuthukisa amazinga akho e-Anandamide futhi kukusize uthole ukukhululeka ekucindezelekeni.

Isilinganiso se-Anandamide (AEA)

Njengamanye ama-endocannabinoids, umthamo wangaphandle ophansi we-Anandamide usilungele. Ukweqiwa okuphezulu kuyalimaza imizimba yethu. 1.0mg / kg. (ngeKg yesisindo somzimba) kufanelekileisilinganiso se-Anandamide (AEA). Kepha uma uthola izinkinga, kufanele ubonane nodokotela ngokushesha. Komama abakhulelwe nabomama abancelisayo kufanele babonane nodokotela babo ngaphambi kokusetshenziswa kwe-Anandamide (AEA).

I-Anandamide (AEA) Imiphumela emibi

I-Anandamide inokubekezelelana okuphezulu nemiphumela engemihle. Ungahlangabezana nobunzima besikhashana njengokuncipha, isiyezi, noma ukuhlanza. Kwezinye izimo, ukuphathwa kwe-Anandamide (AEA) ngesikhathi sokuncelisa ibele (okufundwa kumagundane amadala) kuholela ekutholeni isisindo, ekuqongeleleni amafutha omzimba, nasekuphikisweni kwe-insulin. Lokhu kwenzeka ngenxa yokwanda kwesifiso sokudla okuholela ekudleni okuphezulu kokudla.

Ukuthenga izithasiselo ze-Anandamide (AEA)

Singakuqonda kalula ukuphila impilo enempilo i-Anandamide (AEA) ibalulekile. Kuyasiza ekuvikeleni nasekulweni nezifo ezahlukahlukene. Ukugwema ukushoda kwe-Anandamide (AEA), kuwukuhlakanipha ukusebenzisa izithako kumthamo obekiwe. Ngokuvamile, i-Anandamide (AEA) itholakala ngamafutha (70% no-90%) namafomu wePowder (50%). I-China isibe ngumkhiqizi omkhulu we Izithasiselo ze-Anandamide (AEA).

I-Cannabidiol (i-CBD) isebenzisa

Okulandelayo ukusetshenziswa kwe-cannabidiol;

● Ukwelapha isifo sokuquleka (isithuthwane)

I-Cannabidiol isetshenziselwa ukwelapha ukuquleka. I-CBD ingathinta iziteshi ze-sodium cell. Into evelele kwisifo sokuwa ukunyakaza okungavamile kwe-sodium engena naphandle kwamaseli. Lokhu kudala ukuthi ubuchopho buvuthe ngokungavamile ngokuholela ekuqulekeni. I-CBD itholakale ukuthi inciphisa lokhu kugeleza okungavamile kwe-sodium yingakho kunciphisa ukuquleka.

Eminye imikhiqizo ye-CBD kufaka phakathi i-Epidiolex ivunyelwe ukwelapha ukuquleka okubangelwa yiLennox-Gastaut syndrome, iDravet syndrome, noma i-tuber sclerosis complex. Lo muthi kadokotela uyasetshenziswa kanye neminye imishanguzo yokulwa nokuquleka ukwelapha ukuqubuka kubantu abaphethwe yi-Sturge-Weber syndrome, i-febrile-related-epilepsy syndrome, kanye nokuphazamiseka okuthile kofuzo okubangela i-encephalopathy yesithuthwane.

Ocwaningweni lwango-2016 olubandakanya abantu abangama-214 abaphethwe yisifo sokuwa, i-CBD yanikezwa i-2 iye ku-5 mg nsuku zonke amasonto ayi-12 ngaphezu kwemithi ekhona yesifo sokuwa. Kutholakale ukuthi ababambiqhaza babe nokuquleka okumbalwa okwenzeka ngenyanga.

● Ingasetshenziselwa ukwelapha umdlavuza

Amafutha e-Cannabidiol angasetshenziselwa ukunciphisa izimpawu ezihambisana nomdlavuza kanye nemiphumela emibi yokwelashwa komdlavuza njengobuhlungu, isicanucanu nokuhlanza.

Ekucwaningweni kweziguli ezinomdlavuza eziyi-16 ezelashwa ngamakhemikhali, i-CBD esetshenziswe kanye ne-THC kwatholakala ukuthi inciphisa imiphumela emibi ehlobene namakhemikhali efana nesicanucanu nokuhlanza.

Olunye ucwaningo lukhombise ukuthi i-CBD ivimbela ngempumelelo ukwanda komdlavuza webele kumagundane.

● Kukhombisa izakhiwo ezingavikeli isivikelo

Ikhono le-CBD lokuthonya uhlelo lwe-endocannabinoid nezinye izinhlelo zokufaka uphawu ebuchosheni kuyenza izuzise kubantu abanezifo zemizwa. Amafutha e-CBD nawo anganciphisa ukuvuvukala okuhambisana nokuphazamiseka kwe-neurodegenerative.

Izifundo eziningi zigxile ekusetshenzisweni kwe-CBD ekwelapheni ukuphazamiseka kwemizwa okufana nesifo sokuwa kanye ne-multiple sclerosis. Ucwaningo luphakamisa ukusetshenziswa kwalo okungaba khona ekwelapheni ezinye izifo ezifana nesifo i-Alzheimer's kanye nesifo sikaParkinson.

Ocwaningweni lwesikhathi eside lwamagundane olwenzelwe isifo i-Alzheimer's, i-CBD itholwe ukuvimbela ukwehla kwengqondo.

● Ukwelapha isifo sikashukela sohlobo 1

Uhlobo lwesifo sikashukela sohlobo 1 luhlobo lwesifo sikashukela olwenzeka lapho amasosha omzimba ehlasela amangqamuzana amanyikwe, lokhu kubangela ukuvuvukala.

I-CBD itholakale inezindawo ezilwa nokuvuvukala, ngakho-ke inganciphisa ukuvuvukala noma ibambezele nokuvela kohlobo lwesifo sikashukela sohlobo 1.

Ocwaningweni lwamagundane anesifo sikashukela, i-CBD itholakale ivikela ama-neurons ngokuvimbela ukwehla kwengqondo nokunciphisa ukuvuvukala kwezinzwa.

Izinzuzo zeCannabidiol (CBD)

I-Cannabidiol inezinzuzo ezahlukahlukene zokwelapha.
Ngezansi kunezinye izinzuzo ze-cannabidiol;

● Kunganciphisa ukukhathazeka nokudangala

I-Cannabidiol (i-CBD) ingasiza ekwehliseni ukukhathazeka futhi yehlise nokuziphatha okuhlobene nokukhathazeka okuhambisana nezimo ezinjengesifo sokukhathazeka esijwayelekile, ukuphazamiseka kovalo, ukukhathazeka kokukhathazeka komphakathi, kanye ne-post-traumatic stress disorder (PTSD).

Ocwaningweni lwamagundane, i-cannabidiol itholakale ikhombisa imiphumela yokulwa nokukhathazeka kanye ne-antidepressant.

● Kungadambisa izinhlungu

I-CBD inikeza ukukhululeka kobuhlungu bemvelo kunemithi ejwayelekile.

Imizimba yethu iqukethe uhlelo olukhethekile lwe-endocannabinoid olubhekele ukulawula ukulala, ubuhlungu, ukuvuvukala, kanye nokuphendula kwesistimu yomzimba. Umzimba ngaleyo ndlela ukhiqiza ama-endocannabinoids, ama-neurotransmitters abopha kuma-cannabinoid receptors ohlelweni lwakho lwezinzwa.

I-CBD ikhonjisiwe ukuthi inomthelela ohlelweni lwe-endocannabinoid ngaleyo ndlela inciphisa ubuhlungu nokuvuvukala.

Ngokuhlanganiswa ne-THC, uwoyela we-CBD ungasetshenziswa ekwelapheni ubuhlungu obuhlobene nezimo ezahlukahlukene njenge-multiple sclerosis, isifo samathambo, ubuhlungu bezinzwa zesayensi kanye nokulimala kwentambo yomgogodla.

Ocwaningweni lwabantu abane-arthritis ye-rheumatoid, i-CBD esetshenziswe kanye ne-THC kutholakale ukuthi iqeda kakhulu ubuhlungu ngesikhathi sokunyakaza nokuphumula kanye nekhwalithi yokulala esezigulini.

● Kunganciphisa induna

Izinduna yisimo sesikhumba esithinta abantu abaningi. Kungahle kube ngenxa yezakhi zofuzo, ukuvuvukala, nokukhiqizwa ngokweqile kwe-sebum (into enamafutha eyenziwe yizindlala zesace esikhumbeni).

Ucwaningo lukhombisa ukuthi i-CBD ingasiza ekwehliseni induna ngokwenza njenge-anti-inflammatory agent kanye nokunciphisa ukukhiqizwa kwe-sebum.

Isibonelo, isifundo somuntu sathola ukuthi uwoyela we-CBD ukwazile ukuvimbela ukukhiqizwa ngokweqile kwe-sebum yizindlala ezibusayo ngaleyo ndlela ukwelashwa okuphumelelayo kwezinduna.

● Kungasiza ukuyeka ukubhema nokubhema izidakamizwa

I-CBD ngesimo se-inhaler ingasiza ababhemayo ukuthi basebenzise osikilidi abambalwa futhi banciphise ukulutha kwabo i-nicotine. Lokhu kudlala indima ekusizeni umuntu ayeke ukubhema.

Ocwaningweni lwango-2018 i-CBD yaphawulwa ukusiza ukwehlisa isifiso sogwayi ngemuva kokuhoxa. Kutholakale kusiza umuntu ukuthi akhululeke.

ICannabidiol (CBD) ingahlinzeka ngezinye izinzuzo kufaka phakathi;

  • Kwangathi kungasiza abantu abanokuqwasha ukuba bathole ubuthongo obuphezulu nobungaphazanyiswa
  • Ingakukhulula ekhanda noma ku-migraine,
  • Kungasiza futhi ukunciphisa isicanucanu,
  • Kungasiza ukukhulula ukungezwani komzimba noma i-asthma
  • Ingasetshenziswa ekwelapheni izimo zamaphaphu.

Umthamo weCannabidiol (CBD)

Umthamo kawoyela weCannabidiol uncike ohlotsheni lokuphatha, inhloso ehlosiwe, ubudala, nezinye izimo ezingaphansi. Uma uhlose ukusebenzisa uwoyela we-cannabidiol kufanele ubonane nodokotela wakho ukuthi ungawathatha kanjani uwoyela we-CBD ngaphambi kokuwuthola ukuze uthole izeluleko zochwepheshe ngokusetshenziswa okufanele nomthamo. Ungawathatha kanjani uwoyela we-CBD kuzoya ngohlobo lokuphatha kubandakanya;

  • ithebhulethi namaphilisi athathwa ngomlomo noma ngokuncanyana
  • Amafutha e-Cbd athathwa ngomlomo
  • Amafutha e-Cbd okusetshenziswa esikhunjeni
  • Izifutho zamakhala okuhogela umoya

Njengoba i-cannabidiol isha sha akukho mkhawulo ojwayelekile wokusetshenziswa okuhlukahlukene. Kodwa-ke, i-FDA ivume ukusetshenziswa kwe-Epidiolex, engenye yemikhiqizo etholakala nge-cannabis. Kuvunyelwe ukwelashwa kwesifo sokuwa okukhulu okubangelwa i-Dravet syndrome noma i-Lennox-Gastaut syndrome.

Umthamo onconyiwe we-Epidiolex ume kanjena:

  • Isilinganiso sokuqala singu-2.5 mg / Kg wesisindo somzimba esithathwa kabili ngosuku, okwenza isilinganiso esiphelele esingu-5 mg / kg usuku ngalunye.
  • Ngemuva kwesonto eli-1, umthamo ungakhuphukela ku-5 mg / kg kabili ngosuku, okuyi-10 mg / kg ephelele ngosuku.

Ngenkathi izinzuzo eziningi zika-oyela ze-CBD zibekiwe omunye angathola imiphumela emibi ye-cannabidiol kufaka phakathi isicanucanu, ukukhathala, isifo sohudo, ukungabi nesifiso sokudla nokucasuka.

I-Cannabidiol (CBD) iyathengiswa (Thenga i-Cannabidiol (i-CBD) ngobuningi)

Uwoyela weCannabidiol uyathengiswa utholakala kalula online. Kodwa-ke, uma ucabanga ukuthi i-cannabidiol ithenge emthonjeni othembekile ovunyelwe ukuthengisa uwoyela we-cannabidiol ukuthola uwoyela we-CBD ongcono kakhulu.

Ungahlola ukubuyekezwa kwamakhasimende kumawebhusayithi amaningi ukuthola umphakeli wemikhiqizo we-CBD othembekile onikela ngamafutha we-CBD ahamba phambili.

Thenga njalo i-cannabidiol (i-CBD) ngobuningi ukuze ujabulele amanani entengo.

Landela imiyalo yokuthi ungathatha kanjani uwoyela we-CBD ngokucophelela ukuze ugweme ukuhlangabezana nemiphumela emibi kawoyela we-CBD.

Kuzo yiwaphi thenga i-Anandamide (AEA) powder ngobuningi

Cofttek   umkhiqizo

Isungulwe ngonyaka we-2008, iCofttek iyinkampani esezingeni eliphakeme yeDietary Supplement evela eLuohe City, esifundazweni saseHenan, eChina.

Iphakheji: 25kg / isigubhu

Ngiyethemba ukuthi lokhu kuyasiza !! Ngabe usalindeni lapho? Thola i-Anandamide ekhaya futhi wenze impilo ibe lula!

Isihloko ngu: UDkt. Zeng

Isihloko ngu:

UDkt Zeng

Co-founder, ubuholi benkampani obuyinhloko bokuphatha; I-PhD itholwe kuFudan University ku-organic chemistry. Isipiliyoni seminyaka engaphezu kwengu-10 ku-organic chemistry kanye nokwakhiwa kwezidakamizwa synthesis; Cishe amaphepha ocwaningo ayishumi ashicilelwe emaphephandabeni anegunya, anamalungelo obunikazi angaphezu kwamahlanu aseChina.

Okubhekwayo

UMallet PE, uBeninger RJ (1). "I-endo native cannabinoid receptor agonist anandamide iphazamisa imemori kumagundane". Ukuziphatha Kwemithi. 1996 (7): 3–276

UMechoulam R, uFride E (2). "Umgwaqo ongagandayiwe oya ezingqondweni ze-endo native cannabinoid ligands, i-anandamides". Ku-Pertwee RG (ed.). Ama-cannabinoid receptors. IBoston: I-Academic Press. emakh. 1995–

(3) .URapino, C.; IBattista, N.; UBari, M .; IMaccarrone, M. (2014). "Ama-Endocannabinoids njengama-biomarkers wokukhiqiza kabusha komuntu". Ukuvuselelwa Komuntu. 20 (4): 501-516.

(4).(2015). I-Cannabidiol (i-CBD) kanye nama-analogs ayo: ukubuyekezwa kwemiphumela yokuvuvukala. I-Bioorganic & Medicinal Chemistry, 23 (7), 1377-1385.

ICorroon, J., & Phillips, JA (5). Isifundo Esinqamula Esigabeni Sabasebenzisi beCannabidiol. Ucwaningo lwe-cannabis kanye ne-cannabinoid, 2018 (3), 1-152.

(6).Isikhungo Sikazwelonke Semininingwane Ye-Biotechnology (2020). Isifinyezo sePubChem Compound seCID 644019, iCannabidiol. Ibuyiswe ngo-Okthoba 27, 2020, kusuka ku- .

(7) .R de Mello Schier, A., P de Oliveira Ribeiro, N., S Coutinho, D., Machado, S., Arias-Carrión, O., A Crippa, J.,… noC Silva, A . (2014). Imiphumela efana ne-anti-depressant kanye ne-anxiolytic-efana ne-cannabidiol: ikhemikhali ehlanganisa i-Cannabis sativa. I-CNS ne-Neurological Disorder-Okuqondiwe Kwezidakamizwa (Phambilini Okukhonjiwe Ngezidakamizwa Zamanje-i-CNS kanye Ne-Neurological Disorders), 13 (6), 953-960.

Ukubusisa, EM, Steenkamp, ​​MM, Manzanares, J., & Marmar, CR (8). I-Cannabidiol njengokwelashwa okungenzeka kube nezinkinga zokukhathazeka. I-Neurotherapeutics: iphephabhuku le-American Society for Experimental NeuroTherapeutics12(4), i-825-836.

(9).I-Anandamide (AEA) (94421-68-8)

(10).Uhambo lokuhlola i-egt.

(11).I-Oleoylethanolamide (oea) –i-wand yemilingo yempilo yakho

(12).Konke odinga ukukwazi mayelana ne-nicotinamide riboside chloride.

(13).Izithasiselo ze-Magnesium l-threonate: izinzuzo, isilinganiso, nemiphumela emibi.

(14).I-Palmitoylethanolamide (ipea): izinzuzo, isilinganiso, ukusetshenziswa, ukwengeza.

(15).Izinzuzo eziphezulu zezempilo eziyi-6 zezengezo ze-resveratrol.

(16).Izinzuzo ezi-5 eziphezulu zokuthatha i-phosphatidylserine (ps).

(17).Izinzuzo ezi-5 eziphezulu zokuthatha i-pyrroloquinoline quinone (pqq).

(18).Isengezo esihle kakhulu se-alpha gpc.

(19).Isengezo esihle kakhulu sokulwa nokuguga se-nicotinamide mononucleotide (nmn).